Block of single cardiac Na+ channels by antiarrhythmic drugs: The effect of amiodarone, propafenone and diprafenone

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Down-Regulation of Na⁺/K⁺ATPase Activity by Human Parvovirus B19 Capsid Protein VP1

2013 • 8,607 citations

Regulation of the Voltage Gated K<sup>+</sup> Channel K<sub>v1.3</sub> by Recombinant Human Klotho Protein

2014 • 5,592 citations

Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.

1977 • 1,746 citations

Fitting and Statistical Analysis of Single-Channel Records

1983 • 1,098 citations

Sodium and calcium channels in bovine chromaffin cells

1982 • 983 citations

Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels

1977 • 899 citations

A reinterpretation of mammalian sodium channel gating based on single channel recording

1983 • 675 citations

The Inhibition of Sodium Currents in Myelinated Nerve by Quaternary Derivatives of Lidocaine

1973 • 660 citations

Ionic selectivity, saturation, and block in sodium channels. A four-barrier model.

1975 • 400 citations

Mechanism of frequency-dependent inhibition of sodium currents in frog myelinated nerve by the lidocaine derivative GEA.

1975 • 387 citations

Mechanisms of use-dependent block of sodium channels in excitable membranes by local anesthetics

1984 • 333 citations

Statistical properties of single sodium channels.

1984 • 280 citations

Slow currents through single sodium channels of the adult rat heart.

1985 • 242 citations

Pacemaker activity and mitosis in cultures of newborn rat heart ventricle cells

1966 • 240 citations

Cardiac Na currents and the inactivating, reopening, and waiting properties of single cardiac Na channels.

1985 • 239 citations

Heart cells in culture: A simple method for increasing the proportion of myoblasts

1971 • 229 citations

The site of action and active form of local anesthetics. II. Experiments with quaternary compounds.

1970 • 221 citations

Effect of N-bromoacetamide on single sodium channel currents in excised membrane patches.

1982 • 216 citations

Block of inactivated sodium channels and of depolarization-induced automaticity in guinea pig papillary muscle by amiodarone.

1984 • 213 citations

Inhibition of sodium currents in frog ranvier node treated with local anesthetics Role of slow sodium inactivation

1976 • 200 citations

Sodium channels in cultured cardiac cells.

1983 • 173 citations

Statistical analysis of single sodium channels. Effects of N-bromoacetamide

1984 • 165 citations

Glycocalyx is not required for slow inward calcium current in isolated rat heart myocytes

1980 • 150 citations

Antiarrhythmic agents: modulated receptor applications.

1987 • 143 citations

Modification of single Na+ channels by batrachotoxin.

1982 • 137 citations

Cardioactive substances that prolong the open state of sodium channels

1982 • 132 citations

Amiodarone blocks inactivated cardiac sodium channels

1983 • 120 citations

Evidence for two transient sodium currents in the frog node of Ranvier.

1985 • 109 citations

Modification of single cardiac Na+ channels by DPI 201-106

1986 • 90 citations

Inhibiton of $$\dot V_{\max } $$ of the action potential by propafenone and its voltage-, time- and pH-dependence in mammalian ventricular myocardium

1980 • 77 citations

Na+ channels as sites of action of the cardioactive agent DPI 201-106 with agonist and antagonist enantiomers.

1987 • 66 citations

Tonic and phasicI Na blockade by antiarrhythmics

1983 • 63 citations

Negative inotropic effects of tetrodotoxin and seven class 1 antiarrhythmic drugs in relation to sodium channel blockade

1986 • 54 citations

Properties of normal and non-inactivating single cardiac Na ⁺ channels

1987 • 52 citations

Opentime heterogeneity during bursting of sodium channels in frog skeletal muscle

1986 • 49 citations

Interaction between sodium channels in mouse neuroblastoma cells

1985 • 30 citations

Properties ofV max block of INa-mediated action potentials during combined application of antiarrhythmic drugs in cardiac muscle

1985 • 23 citations