Tonic and phasicI Na blockade by antiarrhythmics

Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.

1977 • 1,746 citations

Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels

1977 • 899 citations

The Combinations of Haemoglobin with Oxygen and with Carbon Monoxide. I

1913 • 777 citations

Effects of calcium ions and local anaesthetics on electrical properties of Purkinje fibres

1955 • 708 citations

The Inhibition of Sodium Currents in Myelinated Nerve by Quaternary Derivatives of Lidocaine

1973 • 660 citations

Sodium current in single rat heart muscle cells.

1981 • 324 citations

Effect of lidocaine and quinidine on steady-state characteristics and recovery kinetics of (dV/dt)max in guinea pig ventricular myocardium.

1975 • 206 citations

The binding of labelled tetrodotoxin to non‐myelinated nerve fibres

1972 • 206 citations

Local anesthetic block of sodium channels in normal and pronase-treated squid giant axons

1978 • 204 citations

Inhibition of sodium currents in frog ranvier node treated with local anesthetics Role of slow sodium inactivation

1976 • 200 citations

Interactions between quaternary lidocaine, the sodium channel gates, and tetrodotoxin

1979 • 197 citations

Tetrodotoxin block of sodium channels in rabbit Purkinje fibers. Interactions between toxin binding and channel gating.

1981 • 184 citations

Analytical models of propagation in excitable cells

1976 • 166 citations

Voltage clamp measurements of sodium channel properties in rabbit cardiac Purkinje fibres.

1980 • 154 citations

Ionic mechanisms in heart muscle in relation to the genesis and the pharmacological control of cardiac arrhythmias.

1978 • 128 citations

Mechanism of action of antifibrillatory drugs

1971 • 116 citations

Sodium inactivation mechanism modulates QX-314 block of sodium channels in squid axons

1978 • 96 citations

Low intracellular pH and chemical agents slow inactivation gating in sodium channels of muscle

1980 • 93 citations

PH-Dependent effects of quinidine on the kinetics of dV/dtmax in guinea pig ventricular myocardium.

1982 • 79 citations

Sodium inactivation and drug-induced immobilization of the gating charge in nerve membrane

1981 • 67 citations

The dependence of the maximum rate of rise of the action potential upstroke on membrane properties

1981 • 51 citations

Mechanism of action of antifibrillatory drugs

1971 • 45 citations

A quantitative analysis of the Na+-dependence of $$\dot V_{max} $$ of the fast action potential in mammalian ventricular myocardium

1982 • 34 citations

Tetrodotoxin sensitivity in the developing and adult chick heart

1981 • 29 citations

Influence of intercellular clefts on potential and current distribution in a multifiber preparation

1980 • 15 citations

[Effect of anestezin (benzocaine) on the sodium gating currents of the membranes of nodes of Ranvier].

1979 • 12 citations

[Blocking of gating currents in node of Ranvier membranes after exposure to the quaternary derivative of lidocaine QX-572].

1979 • 10 citations