Chronic Oral Estrogen Affects Memory and Neurochemistry in Middle-Aged Female Mice.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Place navigation impaired in rats with hippocampal lesions

1982 • 6,277 citations

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1991 • 4,120 citations

Neurotrophins as synaptic modulators

2001 • 1,773 citations

Identification and localization of synaptophysin, an integral membrane glycoprotein of Mr 38,000 characteristic of presynaptic vesicles

1985 • 1,425 citations

Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat.

1992 • 1,178 citations

Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat

1993 • 1,066 citations

A prospective study of estrogen replacement therapy and the risk of developing Alzheimer's disease

1997 • 965 citations

Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat [published erratum appears in J Neurosci 1992 Oct;12(10):following table of contents]

1992 • 959 citations

A 38,000-dalton membrane protein (p38) present in synaptic vesicles.

1985 • 856 citations

Estrogen Deficiency and Risk of Alzheimer's Disease in Women

1994 • 843 citations

Hippocampal connections and spatial discrimination

1978 • 836 citations

Effects of estrogen on memory function in surgically menopausal women

1992 • 728 citations

Impaired Recognition Memory in Rats after Damage to the Hippocampus

2000 • 718 citations

Estrogen and/or androgen replacement therapy and cognitive functioning in surgically menopausal women

1988 • 708 citations

Hippocampal Damage and Exploratory Preferences in Rats: Memory for Objects, Places, and Contexts

2002 • 703 citations

Spontaneous object recognition and object location memory in rats: the effects of lesions in the cingulate cortices, the medial prefrontal cortex, the cingulum bundle and the fornix

1997 • 652 citations

Identification of a putative estrogen response element in the gene encoding brain-derived neurotrophic factor.

1995 • 542 citations

Loss of the Presynaptic Vesicle Protein Synaptophysin in Hippocampus Correlates with Cognitive Decline in Alzheimer Disease

1997 • 535 citations

Neurotrophic factors in Alzheimer’s and Parkinson’s disease brain

2000 • 486 citations

Estradiol Enhances Learning and Memory in a Spatial Memory Task and Effects Levels of Monoaminergic Neurotransmitters

1998 • 441 citations

The nature of the effect of female gonadal hormone replacement therapy on cognitive function in post-menopausal women: a meta-analysis

2000 • 434 citations

The effect of ovariectomy and estradiol replacement on brain-derived neurotrophic factor messenger ribonucleic acid expression in cortical and hippocampal brain regions of female Sprague-Dawley rats.

1995 • 422 citations

Quantitative synaptic alterations in the human neocortex during normal aging

1993 • 408 citations

Long-term treatment with estrogen and progesterone enhances acquisition of a spatial memory task by ovariectomized aged rats☆

2000 • 404 citations

Regulation of Dendritic Spine Density in Cultured Rat Hippocampal Neurons by Steroid Hormones

1996 • 402 citations

Estrogen Enhances Performance of Female Rats during Acquisition of a Radial Arm Maze

1997 • 355 citations

Estrogen alters hippocampal dendritic spine shape and enhances synaptic protein immunoreactivity and spatial memory in female mice

2004 • 349 citations

Neurotoxic lesions of the perirhinal cortex do not mimic the behavioural effects of fornix transection in the rat

1996 • 344 citations

Age differences in spatial memory in a virtual environment navigation task

2001 • 339 citations

Estrogen and exercise interact to regulate brain‐derived neurotrophic factor mRNA and protein expression in the hippocampus

2001 • 324 citations

Age-related spatial reference and working memory deficits assessed in the water maze

1995 • 314 citations

Estradiol facilitates performance as working memory load increases

1999 • 303 citations

Effects of Stress and Hippocampal NMDA Receptor Antagonism on Recognition Memory in Rats

2002 • 292 citations

Levels of trkA and BDNF mRNA, but not NGF mRNA, fluctuate across the estrous cycle and increase in response to acute hormone replacement

1998 • 260 citations

Functionally Dissociating Aspects of Event Memory: the Effects of Combined Perirhinal and Postrhinal Cortex Lesions on Object and Place Memory in the Rat

1999 • 253 citations

A Beneficial Effect of Estrogen on Working Memory in Postmenopausal Women Taking Hormone Replacement Therapy

2000 • 247 citations

Role of neurotrophins in central synapse formation and stabilization

2002 • 243 citations

Brain-derived neurotrophic factor mediates estradiol-induced dendritic spine formation in hippocampal neurons

1998 • 242 citations

Increased Synaptic Sprouting in Response to Estrogen via an Apolipoprotein E-Dependent Mechanism: Implications for Alzheimer’s Disease

1998 • 241 citations

Effects of Estrogen Replacement on the Relative Levels of Choline Acetyltransferase, trkA, and Nerve Growth Factor Messenger RNAs in the Basal Forebrain and Hippocampal Formation of Adult Rats

1994 • 232 citations

Estrogen Improves Working But Not Reference Memory and Prevents Amnestic Effects of Scopolamine on a Radial-Arm Maze

1999 • 227 citations

Effectiveness of Estrogen Replacement in Restoration of Cognitive Function after Long-Term Estrogen Withdrawal in Aging Rats

2002 • 223 citations

Different modes of hippocampal plasticity in response to estrogen in young and aged female rats

2001 • 223 citations

Hippocampal neuron and synaptophysin-positive bouton number in aging C57BL/6 mice

1998 • 218 citations

Estrogen replacement improves spatial reference memory and increases hippocampal synaptophysin in aged female mice

2002 • 204 citations

Sex Dimorphisms in the Rate of Age-Related Decline in Spatial Memory: Relevance to Alterations in the Estrous Cycle

1999 • 196 citations

Sex Differences in the Behavioral Response to Spatial and Object Novelty in Adult C57BL/6 Mice.

2003 • 192 citations

Estrogen, Cognition, and a Woman’s Risk of Alzheimer’s Disease

1997 • 191 citations

Treatment with estrogen and progesterone affects relative levels of brain-derived neurotrophic factor mRNA and protein in different regions of the adult rat brain

1999 • 187 citations

Expression of BDNF and trkB as a function of age and cognitive performance

1998 • 186 citations

Posttraining Estradiol Injections Enhance Memory in Ovariectomized Rats: Cholinergic Blockade and Synergism

1997 • 179 citations

Estradiol Increases Spine Density and NMDA-Dependent Ca²⁺Transients in Spines of CA1 Pyramidal Neurons From Hippocampal Slices

1999 • 177 citations

Posttraining Estrogen and Memory Modulation

1998 • 174 citations

High levels of estradiol disrupt conditioned place preference learning, stimulus response learning and reference memory but have limited effects on working memory

2001 • 173 citations

Effects of Environmental Enrichment on Spatial Memory and Neurochemistry in Middle-Aged Mice

2003 • 161 citations

Decreased synaptic density in aged brains and its prevention by rearing under enriched environment as revealed by synaptophysin contents

1994 • 160 citations

Novel Target Sites for Estrogen Action in the Dorsal Hippocampus: An Examination of Synaptic Proteins¹

2001 • 151 citations

Cortical Synaptic Changes and Gliosis in Normal Aging, Alzheimer's Disease and Frontal Lobe Degeneration

1996 • 151 citations

Age-related deficits as working memory load increases: relationships with growth factors

2002 • 150 citations

Effects of estrogen and fimbria/fornix transection on p75NGFR and ChAT expression in the medial septum and diagonal band of Broca

1992 • 149 citations

Memory for Object Locations in Young and Elderly Adults

1987 • 146 citations

Ovarian Hormone Replacement to Aged Ovariectomized Female Rats Benefits Acquisition of the Morris Water Maze

2002 • 143 citations

Neuroendocrine involvement in aging: Evidence from studies of reproductive aging and caloric restriction

1995 • 136 citations

Interaction of age and chronic estradiol replacement on memory and markers of brain aging

2003 • 136 citations

Granule Cells in Aging Rats Are Sexually Dimorphic in Their Response to Estradiol

1999 • 135 citations

Cognitive Mapping and Elderly Adults: Verbal and Location Memory for Urban Landmarks

1984 • 135 citations

Spatial reference memory and neocortical neurochemistry vary with the estrous cycle in C57BL/6 mice.

2001 • 133 citations

Influence of estradiol, stress, and 5-HT2A agonist treatment on Brain-Derived Neurotrophic Factor expression in female rats

2003 • 123 citations

Correlation between hippocampal BDNF mRNA expression and memory performance in senescent rats

2001 • 117 citations

The effect of excitotoxic lesions centered on the hippocampus or perirhinal cortex in object recognition and spatial memory tasks.

2001 • 115 citations

In two species, females exhibit superior working memory and inferior reference memory on the water radial-arm maze

2000 • 114 citations

Synaptic loss in cognitively impaired aged rats is ameliorated by chronic human nerve growth factor infusion

1995 • 113 citations

Effects of Ovariectomy and Estrogen Treatment on Learning and Hippocampal Neurotransmitters in Mice

2002 • 110 citations

Estrogen up-regulates estrogen receptor α and synaptophysin in slice cultures of rat hippocampus

2002 • 109 citations

Estrogen and cognitive aging in women

2002 • 108 citations

Quantitative Assessment of the Synaptophysin Immuno-Reactivity of the Cortical Neuropil in Various Neurodegenerative Disorderswith Dementia

1993 • 106 citations

The effect of ovariectomy and estradiol replacement on brain-derived neurotrophic factor messenger ribonucleic acid expression in cortical and hippocampal brain regions of female Sprague-Dawley rats

1995 • 106 citations

Region- and peptide-specific regulation of the neurotrophins by estrogen

2000 • 105 citations

Effects of aging on spatial learning and hippocampal protein kinase c in mice

1993 • 103 citations

Estrogen effects on object memory and cholinergic receptors in young and old female mice

2002 • 102 citations

Estrogen modulates spontaneous alternation and the cholinergic phenotype in the basal forebrain

1999 • 102 citations

Synaptophysin gene expression in human brain: A quantitative in situ hybridization and immunocytochemical study

1994 • 93 citations

Regulation of Estrogen Receptor Concentrations in the Rat Brain: Effects of Sustained Androgen and Estrogen Exposure

1996 • 91 citations

Involvement of the hippocampal CA3-region in acquisition and in memory consolidation of spatial but not in object information in mice

2003 • 83 citations

Male mice exhibit better spatial working and reference memory than females in a water-escape radial arm maze task

2003 • 83 citations

Preservation of accurate spatial memory in aged rats

1985 • 81 citations

Discussion

1999 • 80 citations

Septo-hippocampal cholinergic and neurotrophin markers in age-induced cognitive decline

1998 • 74 citations

Expression and estrogen regulation of brain‐derived neurotrophic factor gene and protein in the forebrain of female prairie voles

2001 • 63 citations

Role of nitric oxide in the effect of aging on spatial memory in rats

1997 • 61 citations

Novel Target Sites for Estrogen Action in the Dorsal Hippocampus: An Examination of Synaptic Proteins

2001 • 54 citations

Effective Oral Administration of 17β-Estradiol to Female C57BL/6J Mice through the Drinking Water1

1986 • 53 citations

Working memory deficits in BXSB mice with neocortical ectopias

2000 • 45 citations

Simplifying environmental cues in a Morris-type water maze improves place learning in old NMRI mice

1991 • 42 citations

Synaptophysin immunogold labelling of synapses decreases in dentate gyrus of the hippocampus of aged rats

2003 • 37 citations

Effects of carbon dioxide-induced anesthesia on cholinergic parameters in rat brain.

1994 • 33 citations

Non-spatial water radial-arm maze learning in mice

2000 • 30 citations