Pro-coagulant state resulting from high levels of soluble P-selectin in blood

Circulating adhesion molecules in disease

1993 • 1,425 citations

Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice

1993 • 1,058 citations

Blood-borne tissue factor: Another view of thrombosis

1999 • 982 citations

Mechanisms That Regulate the Function of the Selectins and Their Ligands

1999 • 931 citations

Elevated Levels of Shed Membrane Microparticles With Procoagulant Potential in the Peripheral Circulating Blood of Patients With Acute Coronary Syndromes

2000 • 876 citations

Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets

1992 • 800 citations

In vitro generation of endothelial microparticles and possible prothrombotic activity in patients with lupus anticoagulant

1999 • 720 citations

P-selectin induces the expression of tissue factor on monocytes.

1994 • 595 citations

Cellular origin and procoagulant properties of microparticles in meningococcal sepsis

2000 • 568 citations

In vivo tracking of platelets: circulating degranulated platelets rapidly lose surface P-selectin but continue to circulate and function.

1996 • 552 citations

Direct detection of activated platelets and platelet-derived microparticles in humans

1990 • 429 citations

Transfer of tissue factor from leukocytes to platelets is mediated by CD15 and tissue factor

2000 • 387 citations

Oligospecificity of the cellular adhesion receptor Mac-1 encompasses an inducible recognition specificity for fibrinogen.

1988 • 374 citations

Monocyte vesiculation is a possible mechanism for dissemination of membrane-associated procoagulant activities and adhesion molecules after stimulation by lipopolysaccharide.

1994 • 367 citations

Leukocyte Microparticles Stimulate Endothelial Cell Cytokine Release and Tissue Factor Induction in a JNK1 Signaling Pathway

1999 • 343 citations

Platelet/Polymorphonuclear Leukocyte Interaction: P-Selectin Triggers Protein-Tyrosine Phosphorylation–Dependent CD11b/CD18 Adhesion: Role of PSGL-1 as a Signaling Molecule

1999 • 329 citations

Transfer of tissue factor from leukocytes to platelets is mediated by CD15 and tissue factor

2000 • 324 citations

P-Selectin and Platelet Clearance

1998 • 297 citations

Characterization of GMP-140 (P-selectin) as a circulating plasma protein.

1992 • 264 citations

The Weibel-Palade Body: the Storage Granule for von Willebrand Factor and P-selectin

1993 • 262 citations

Prevention of Activated Neutrophil Adhesion to Endothelium by Soluble Adhesion Protein GMP140

1990 • 257 citations

Plasma P-selectin is increased in thrombotic consumptive platelet disorders

1994 • 253 citations

The Origin of P-selectin as a Circulating Plasma Protein

1997 • 250 citations

L-selectin function is required for beta 2-integrin-mediated neutrophil adhesion at physiological shear rates in vivo

1992 • 239 citations

Five tumor necrosis factor-inducible cell adhesion mechanisms on the surface of mouse endothelioma cells mediate the binding of leukocytes.

1993 • 234 citations

Whole Blood Tissue Factor Procoagulant Activity Is Elevated in Patients With Sickle Cell Disease

1998 • 227 citations

Defects in hemostasis in P-selectin-deficient mice

1996 • 205 citations

Increased Soluble Form of P-Selectin in Patients With Unstable Angina

1995 • 202 citations

Exacerbation of Cerebral Injury in Mice That Express the P-Selectin Gene

1997 • 198 citations

Whole Blood Tissue Factor Procoagulant Activity Is Elevated in Patients With Sickle Cell Disease

1998 • 191 citations

Structure of the human gene encoding granule membrane protein-140, a member of the selectin family of adhesion receptors for leukocytes.

1990 • 181 citations

Soluble Adhesion Molecules Reflect Endothelial Cell Activation in Ischemic Stroke and in Carotid Atherosclerosis

1997 • 158 citations

von Willebrand Factor, Soluble P-Selectin, Tissue Plasminogen Activator and Plasminogen Activator Inhibitor in Atherosclerosis

1995 • 145 citations

Progressive vascular damage in hypertension is associated with increased levels of circulating P-selectin

1998 • 141 citations

Recombinant Soluble Form of PSGL-1 Accelerates Thrombolysis and Prevents Reocclusion in a Porcine Model

1999 • 114 citations

Role of P-Selectin Cytoplasmic Domain in Granular Targeting In Vivo and in Early Inflammatory Responses

1998 • 113 citations

Anti-P-selectin antibody decreases inflammation and thrombus formation in venous thrombosis

1997 • 111 citations

Adhesion protein GMP140 inhibits superoxide anion release by human neutrophils.

1991 • 107 citations

Collagen type III induced ex vivo thrombogenesis in humans. Role of platelets and leukocytes in deposition of fibrin.

1990 • 104 citations

Venous thrombosis prophylaxis by inflammatory inhibition without anticoagulation therapy

2000 • 93 citations

Circulating cell adhesion molecules and endothelial markers before and after transluminal angioplasty in peripheral arterial occlusive disease

1999 • 91 citations

Shwartzman Reaction

1990 • 74 citations

Laboratory Testing for von Willebrand’s Disease: An Assessment of Current Diagnostic Practice and Efficacy by Means of a Multi-laboratory Survey

1999 • 69 citations

Changes in the Levels of Soluble Adhesion Molecules and Coagulation Factors in Patients with Deep Vein Thrombosis

1999 • 63 citations

Role of collagen-adherent platelets in mediating fibrin formation in flowing whole blood

1995 • 52 citations

Intact platelet membranes, not platelet-released microvesicles, support the procoagulant activity of adherent platelets.

1993 • 51 citations

Soluble Monomeric P-Selectin Containing Only the Lectin and Epidermal Growth Factor Domains Binds to P-Selectin Glycoprotein Ligand-1 on Leukocytes

1997 • 51 citations

Soluble Monomeric P-Selectin Containing Only the Lectin and Epidermal Growth Factor Domains Binds to P-Selectin Glycoprotein Ligand-1 on Leukocytes

1997 • 50 citations

Cell Adhesion Molecules in Cardiovascular Disease and Its Risk Factors—What Can Soluble Levels Tell Us?

2000 • 37 citations

Detection of Plasma Alpha-Granule Membrane Protein GMP-140 Using Radiolabeled Monoclonal Antibodies in Thrombotic Diseases

1993 • 37 citations

Intact platelet membranes, not platelet-released microvesicles, support the procoagulant activity of adherent platelets.

1993 • 32 citations

Collagen induced thrombus formation at the apex of eccentric stenoses--a time course study with non-anticoagulated human blood.

1996 • 32 citations

Optimal Antagonism of GPIIb/IIIa Favors Platelet Adhesion by Inhibiting Thrombus Growth

1996 • 29 citations

P-Selectin and Platelet Clearance

1998 • 27 citations

Collagen Induced Thrombus Formation at the Apex of Eccentric Stenoses - A Time Course Study with Non-Anticoagulated Human Blood

1996 • 23 citations