Where is APC going?

Lessons from Hereditary Colorectal Cancer

1996 • 4,900 citations

Wnt signaling: a common theme in animal development

1997 • 2,579 citations

MICROTUBULE POLYMERIZATION DYNAMICS

1997 • 2,442 citations

Genetic instability in colorectal cancers

1997 • 1,989 citations

Linking Colorectal Cancer to Wnt Signaling

2000 • 1,507 citations

Beyond self-assembly: From microtubules to morphogenesis

1986 • 1,334 citations

Wnt Signaling in Oncogenesis and Embryogenesis--a Look Outside the Nucleus

2000 • 1,253 citations

Association of the APC Gene Product with β-Catenin

1993 • 1,215 citations

Association of the APC Tumor Suppressor Protein with Catenins

1993 • 1,202 citations

Mutations in the APC tumour suppressor gene cause chromosomal instability

2001 • 722 citations

A role for the Adenomatous Polyposis Coli protein in chromosome segregation

2001 • 553 citations

The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration.

1996 • 494 citations

APC binds to the novel protein EB1.

1995 • 450 citations

The adenomatous polyposis coli (APC) tumor suppressor

1997 • 446 citations

Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3β phosphorylation

2001 • 435 citations

Binding of APC to the Human Homolog of the Drosophila Discs Large Tumor Suppressor Protein

1996 • 430 citations

The APC gene product associates with microtubules in vivo and promotes their assembly in vitro.

1994 • 406 citations

The dynamic behavior of the APC-binding protein EB1 on the distal ends of microtubules

2000 • 401 citations

Microtubule “Plus-End-Tracking Proteins”

2001 • 361 citations

Asef, a Link Between the Tumor Suppressor APC and G-Protein Signaling

2000 • 350 citations

Wild-type but not mutant APC associates with the microtubule cytoskeleton.

1994 • 319 citations

Adenomatous Polyposis Coli (APC) Protein Moves along Microtubules and Concentrates at Their Growing Ends in Epithelial Cells

2000 • 284 citations

Kar9p Is a Novel Cortical Protein Required for Cytoplasmic Microtubule Orientation in Yeast

1998 • 273 citations

Positioning of the Mitotic Spindle by a Cortical-Microtubule Capture Mechanism

2000 • 271 citations

Eb1 Proteins Regulate Microtubule Dynamics, Cell Polarity, and Chromosome Stability

2000 • 265 citations

Adherens junctions inhibit asymmetric division in the Drosophila epithelium

2001 • 237 citations

NH2-terminal Deletion of β-Catenin Results in Stable Colocalization of Mutant β-Catenin with Adenomatous Polyposis Coli Protein and Altered MDCK Cell Adhesion

1997 • 220 citations

Molecular Linkage Underlying Microtubule Orientation Toward Cortical Sites in Yeast

2000 • 204 citations

Drosophila Apc2 Is a Cytoskeletally-Associated Protein That Regulates Wingless Signaling in the Embryonic Epidermis

1999 • 183 citations

BIM1Encodes a Microtubule-binding Protein in Yeast

1997 • 179 citations

Dynamics of β-Catenin Interactions with APC Protein Regulate Epithelial Tubulogenesis

1997 • 127 citations

A new Drosophila APC homologue associated with adhesive zones of epithelial cells

1999 • 124 citations

Nuclear and cytoplasmic localizations of the adenomatous polyposis coli protein

1997 • 124 citations

Regulation and function of the interaction between the APC tumour suppressor protein and EB1

2000 • 121 citations

Tumor-suppressor gene products in cell contacts: the cad herin-APC-armadillo connection

1994 • 115 citations

Polyclonal structure of intestinal adenomas in Apc ^Min /+ mice with concomitant loss of Apc ⁺ from all tumor lineages

1997 • 101 citations

Subcellular localization of the APC protein: immunoelectron microscopic study of the association of the APC protein with catenin.

1995 • 86 citations

The adenomatous polyposis coli protein: in the limelight out at the edge

2001 • 84 citations

Microtubules don and doff their caps: dynamic attachments at plus and minus ends

2001 • 80 citations

The Role of the Adenomatous Polyposis Coli (Apc) Gene in Human Cancers

1993 • 74 citations

Apical Membrane Localization of the Adenomatous Polyposis Coli Tumor Suppressor Protein and Subcellular Distribution of the β-Catenin Destruction Complex in Polarized Epithelial Cells

2001 • 62 citations

Actin-dependent membrane association of a Drosophila epithelial APC protein and its effect on junctional Armadillo

2000 • 56 citations

Teaching tumour suppressors new tricks

2000 • 24 citations

Microtubule dynamics: The view from the tip

2000 • 13 citations