Inhibition of prostaglandin synthesis in vivo by nonsteroid anti-inflammatory drugs: Evidence for the importance of pharmacokinetics

Drugs which inhibit prostaglandin biosynthesis.

1974 • 1,325 citations

On the mechanism of intestinal absorption of drugs.

1959 • 447 citations

New Aspects of the Mode of Action of Nonsteroid Anti-Inflammatory Drugs

1974 • 427 citations

THE ESTIMATION OF ANTIPYRINE IN BIOLOGICAL MATERIALS

1949 • 411 citations

Intracellular pH.

1969 • 394 citations

Inhibition of Adenosine Diphosphate-Induced Secondary Aggregation and Other Platelet Functions by Acetylsalicylic Acid Ingestion

1968 • 327 citations

Principles of Drug Action.

1969 • 316 citations

Renal tubular mechanisms for excretion of organic acids and bases

1964 • 241 citations

The Distribution and Excretion of Phenobarbital1

1957 • 225 citations

Measurement of synovial fluid pH in normal and arthritic knees

1966 • 157 citations

Biochemical properties of anti-inflammatory drugs—III.

1964 • 152 citations

Stabilization of serum albumin by anti-inflammatory drugs

1970 • 145 citations

THE DETERMINATION OF SALICYLIC ACID IN PLASMA

1944 • 145 citations

A Possible Basis for the Anti-inflammatory Activity of Salicylates and other Non-Hormonal Anti-Rheumatic Drugs

1958 • 126 citations

Salicylate: A Structure-Activity Study of its Effects on Membrane Permeability

1972 • 96 citations

The influence of psychotropic drugs on prostaglandin biosynthesis

1974 • 90 citations

Effects of local anaesthetics on prostaglandin biosynthesis in vitro

1974 • 86 citations

Nonsteroid Anti-Inflammatory Agents

1973 • 77 citations

Studies on the Mode of Action of Non-Steroidal Anti-Inflammatory Agents

1972 • 62 citations

Biochemical properties of anti-inflammatory drugs—VIII

1966 • 55 citations

Dissimilar effects of anti-inflammatory drugs on stability of lysosomes from peritoneal and circulating leukocytes and liver

1971 • 54 citations

Renal and gastric lesions after phenylbutazone and indomethacin in the rat

1974 • 51 citations

Metabolic Control and Intracellular pH during Phagocytosis by Polymorphonuclear Leucocytes

1970 • 47 citations

Leukocytes and prostaglandins in acute inflammation

1974 • 47 citations

How aspirin might work: A pharmacokinetic approach

1974 • 42 citations

A Novel in vitro Assay for Anti-Inflammatory Agents Based on Stabilization of Erythrocytes

1967 • 41 citations

Structure activity relations. 7. Structure-activity relations of fenamic acids

1974 • 40 citations

How aspirin might work: A pharmacokinetic approach

1994 • 39 citations

Measurement of rate of extravasation of plasma protein in inflammatory responses in guinea-pig skin using a continuous recording method.

1974 • 31 citations

The molecular pharmacology of anti-inflammatory drugs: Some possible mechanisms of action at the biochemical level

1968 • 29 citations

The determination of probenecid (benemid) in body fluids.

1954 • 28 citations

The Antihypertensive and Natriuretic Endocrine Function of the Kidney: Vascular and Metabolic Mechanisms of the Renal Prostaglandins

1972 • 16 citations

Fluorometric Determination of Indoxole [2,3-Bis(p-Methoxyphenyl)-Indole] in Biological Specimens.

1966 • 13 citations

Correlation between in vitro and in vivo models in anti-inflammatory drug studies

1971 • 11 citations

[Studies on the problem of peripheral point of attack of pyrazoles with respect to their antiphlogistic effect].

1955 • 7 citations

Localization of butylmalonic acid-mono-(1,2-diphenylhydrazide)-calcium-14C (bumadizone-calcium), a new anti-inflammatory drug, in rats and mice with whole-body autoradiography. Specific localization in the carragenine-inflamed paw and in general experimental polyarthritic rats.

1973 • 4 citations

[The measurement of intracellular pH by DMO method and the buffering capacity of the tissue after acid infusion].

1967 • 2 citations