Mutation in the Magnesium Binding Site of hMSH6 Disables the hMutSα Sliding Clamp from Translocating along DNA

MISMATCH REPAIR IN REPLICATION FIDELITY, GENETIC RECOMBINATION, AND CANCER BIOLOGY

1996 • 1,485 citations

Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation

1989 • 881 citations

Crystal structure of the ATP-binding subunit of an ABC transporter

1998 • 659 citations

Isolation of an hMSH2-p160 Heterodimer That Restores DNA Mismatch Repair to Tumor Cells

1995 • 599 citations

Biochemistry and genetics of eukaryotic mismatch repair.

1996 • 598 citations

GTBP, a 160-Kilodalton Protein Essential for Mismatch-binding Activity in Human Cells

1995 • 528 citations

Mutations of GTBP in Genetically Unstable Cells

1995 • 471 citations

Mutation of a meiosis-specific MutS homolog decreases crossing over but not mismatch correction

1994 • 371 citations

hMSH2–hMSH6 Forms a Hydrolysis-Independent Sliding Clamp on Mismatched DNA

1999 • 368 citations

The Human Mismatch Recognition Complex hMSH2-hMSH6 Functions as a Novel Molecular Switch

1997 • 357 citations

Heteroduplex repair in extracts of human HeLa cells

1991 • 355 citations

Escherichia coli mutS-encoded protein binds to mismatched DNA base pairs.

1986 • 353 citations

MutS mediates heteroduplex loop formation by a translocation mechanism

1997 • 325 citations

Replication errors: cha(lle)nging the genome

1998 • 209 citations

A phylogenomic study of the MutS family of proteins

1998 • 201 citations

Nucleotide-promoted Release of hMutSα from Heteroduplex DNA Is Consistent with an ATP-dependent Translocation Mechanism

1998 • 190 citations

hMSH2 and hMSH6 play distinct roles in mismatch binding and contribute differently to the ATPase activity of hMutSalpha

1998 • 173 citations

Altering the conserved nucleotide binding motif in the Salmonella typhimurium MutS mismatch repair protein affects both its ATPase and mismatch binding activities.

1991 • 164 citations

A human 200-kDa protein binds selectively to DNA fragments containing G.T mismatches.

1988 • 126 citations

Superfamily of UvrA-related NTP-binding proteins

1990 • 125 citations

MSH6, a Saccharomyces cerevisiae protein that binds to mismatches as a heterodimer with MSH2

1996 • 101 citations

A Mutation in the MSH6 Subunit of the Saccharomyces cerevisiae MSH2-MSH6 Complex Disrupts Mismatch Recognition

1999 • 95 citations

Mismatch-containing oligonucleotide duplexes bound by theE.coli mutS-encoded protein

1988 • 90 citations

Saccharomyces cerevisiaeMsh2p and Msh6p ATPase Activities Are Both Required during Mismatch Repair

1998 • 90 citations

The purification of a human mismatch-binding protein and identification of its associated ATPase and helicase activities.

1992 • 89 citations

DNA-dependent Activation of the hMutSα ATPase

1998 • 69 citations

Identification of the Magnesium-binding Domain of the High-affinity ATP-binding Site of the Bacillus subtilis and Escherichia coli SecA Protein

1995 • 44 citations

A Partially Functional DNA Helicase II Mutant Defective in Forming Stable Binary Complexes with ATP and DNA

1996 • 37 citations

Characterization of a Potential Catalytic Residue, Asp-133, in the High Affinity ATP-binding Site of SecA, Translocation ATPase

1996 • 27 citations