Cell biology of liver endothelial and Kupffer cells.

Culture of Human Endothelial Cells Derived from Umbilical Veins. IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGIC CRITERIA

1973 • 6,904 citations

The Transforming Growth Factor-beta Family

1990 • 3,028 citations

Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity

1991 • 2,806 citations

LIPOPROTEIN METABOLISM IN THE MACROPHAGE: Implications for Cholesterol Deposition in Atherosclerosis

1983 • 2,306 citations

Endothelial Leukocyte Adhesion Molecule 1: an Inducible Receptor for Neutrophils Related to Complement Regulatory Proteins and Lectins

1989 • 2,045 citations

Evaluation of High-Sensitivity C-Reactive Protein and Serum Lipid Profile in Southeastern Nigerian Women with Pre-Eclampsia

2015 • 2,005 citations

Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes

1989 • 1,715 citations

Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1)

1987 • 1,712 citations

The Biology of Cachectin/TNF -- A Primary Mediator of the Host Response

1989 • 1,679 citations

Some recent advances in the chemistry and biology of transforming growth factor-beta.

1987 • 1,308 citations

Biologically active products of stimulated liver macrophages (Kupffer cells)

1990 • 926 citations

HUMAN ARTERIAL AND VENOUS TISSUES GENERATE PROSTACYCLIN (PROSTAGLANDIN X), A POTENT INHIBITOR OF PLATELET AGGREGATION

1977 • 886 citations

Functional cloning of ICAM-2, a cell adhesion ligand for LFA-1 homologous to ICAM-1

1989 • 837 citations

The Liver Sieve: Considerations Concerning the Structure and Function of Endothelial Fenestrae, the Sinusoidal Wall and the Space of Disse

1985 • 689 citations

Role of integrins and other cell adhesion molecules in tumor progression and metastasis.

1993 • 668 citations

An Inducible Endothelial Cell Surface Glycoprotein Mediates Melanoma Adhesion

1989 • 659 citations

An electron microscopic study of the fenestrated endothelial lining of rat liver sinusoids

1970 • 646 citations

Structure and Function of Leukocyte Integrins

1990 • 620 citations

Distribution and modulation of the cellular receptor for transforming growth factor-beta.

1987 • 556 citations

Prostaglandins as endogenous mediators of interleukin 1 production.

1986 • 541 citations

Cytokines as communication signals between leukocytes and endothelial cells

1989 • 528 citations

Interleukin 1: a mitogen for human vascular smooth muscle cells that induces the release of growth-inhibitory prostanoids.

1988 • 519 citations

Organ specificity of tumor metastasis: role of preferential adhesion, invasion and growth of malignant cells at specific secondary sites

1988 • 508 citations

Extracellular matrix gene expression increases preferentially in rat lipocytes and sinusoidal endothelial cells during hepatic fibrosis in vivo.

1990 • 432 citations

In vitro and in vivo association of transforming growth factor-beta 1 with hepatic fibrosis.

1989 • 420 citations

Role of organ selectivity in the determination of metastatic patterns of B16 melanoma.

1980 • 417 citations

Membrane Proteins Involved in Phagocyte Adherence to Endothelium

1990 • 407 citations

Separation of Kupffer and endothelial cells of the rat liver by centrifugal elutriation

1976 • 399 citations

In vivo and in vitro uptake and degradation of acetylated low density lipoprotein by rat liver endothelial, Kupffer, and parenchymal cells.

1983 • 396 citations

Quantitation, tissue distribution and proliferation kinetics of kupffer cells in normal rat liver

1986 • 359 citations

An L-arginine-dependent mechanism mediates kupffer cell inhibition of hepatocyte protein synthesis in vitro

1989 • 325 citations

Preparation of Pure Hepatocytes and Reticuloendothelial Cells in High Yield From a Single Rat Liver by Means of Percoll Centrifugation and Selective Adherence

1985 • 324 citations

Scavenger functions of the liver endothelial cell

1990 • 324 citations

Cancer Metastasis: Experimental Approaches, Theoretical Concepts, and Impacts for Treatment Strategies

1985 • 301 citations

An ultrastructural characterization of the endothelial cell in the rat liver sinusoid under normal and various experimental conditions, as a contribution to the distinction between endothelial and Kupffer cells

1972 • 299 citations

Stimulation of hepatic lipocyte collagen production by Kupffer cell-derived transforming growth factor β: Implication for a pathogenetic role in alcoholic liver fibrogenesis

1990 • 295 citations

Observations on the fine structure and peroxidase cytochemistry of normal rat liver Kupffer cells

1974 • 293 citations

Different fate in vivo of oxidatively modified low density lipoprotein and acetylated low density lipoprotein in rats. Recognition by various scavenger receptors on Kupffer and endothelial liver cells

1991 • 275 citations

Specificity of adhesion between murine tumor cells and capillary endothelium: an in vitro correlate of preferential metastasis in vivo.

1987 • 250 citations

Circulating C-terminal propeptide of type I procollagen is cleared mainly via the mannose receptor in liver endothelial cells

1990 • 236 citations

Cell types involved in collagen and fibronectin production in normal and fibrotic human liver

1986 • 229 citations

Uptake of chemically modified low density lipoproteins in vivo is mediated by specific endothelial cells.

1985 • 219 citations

Bovine aortic endothelial cells display macrophage-like properties towards acetylated 125I-labelled low density lipoprotein

1980 • 212 citations

Regulation of synthesis and secretion of major rat acute‐phase proteins by recombinant human interleukin‐6 (BSF‐2/1L‐6) in hepatocyte primary cultures

1988 • 190 citations

Recognition and destruction of neoplastic cells by activated macrophages: discrimination of altered self

1988 • 186 citations

Portal Venous and Systemic Endotoxaemia in Patients without Liver Disease and Systemic Endotoxaemia in Patients with Cirrhosis

1976 • 185 citations

Differential effects of interleukin‐1α, tumor necrosis factor α, and transforming growth factor β1 on cell proliferation and collagen formation by cultured fat‐storing cells

1989 • 178 citations

Alcoholic liver injury: Defenestration in noncirrhotic livers—a scanning electron microscopic study

1987 • 178 citations

Cell Biology and Kinetics of Kupffer Cells in the Liver

1989 • 172 citations

Characterization and culture of sinusoidal endothelium from normal rat liver: Lipoprotein uptake and collagen phenotype

1984 • 172 citations

Clearance of NH2-terminal propeptides of types I and III procollagen is a physiological function of the scavenger receptor in liver endothelial cells.

1994 • 169 citations

Biochemical and clinical response of fulminant viral hepatitis to administration of prostaglandin E. A preliminary report.

1989 • 162 citations

Role of extracellular matrix in regulating fenestrations of sinusoidal endothelial cells isolated from normal rat liver

1992 • 159 citations

Assessment of a method of isolation, purification, and cultivation of rat liver sinusoidal endothelial cells.

1994 • 154 citations

Extremely rapid endocytosis mediated by the mannose receptor of sinusoidal endothelial rat liver cells

1989 • 145 citations

Rat hepatic sinusoidal endothelial cells in monolayer culture

1988 • 145 citations

The release of tumor necrosis factor from endotoxin-stimulated rat Kupffer cells is regulated by prostaglandin E2 and dexamethasone

1988 • 140 citations

Bacterial Lipopolysaccharides: Structure, Metabolism and Mechanisms of Action

1990 • 134 citations

Involvement of tumor necrosis factor in endotoxin-triggered neutrophil adherence to sinusoidal endothelial cells of mouse liver and its modulation in acute phase

1988 • 132 citations

Kupffer cell reactions in rat liver under various conditions as observed in the electron microscope

1974 • 130 citations

Transforming growth factor β responsiveness is modulated by the extracellular collagen matrix during hepatic ito cell culture

1988 • 125 citations

Clearance of acetyl low density lipoprotein by rat liver endothelial cells. Implications for hepatic cholesterol metabolism.

1984 • 125 citations

Detection of factor VIII/coagulant antigen in human liver tissue

1983 • 124 citations

Defenestration of the sinusoidal endothelial cell in a rat model of cirrhosis

1993 • 116 citations

Different Growth Pattern and Biologic Behavior of Human Renal Cell Carcinoma Implanted Into Different Organs of Nude Mice<xref ref-type="fn" rid="FN2">2</xref>

1987 • 108 citations

Ultrastructural localization of factor VIII procoagulant antigen in human liver hepatocytes

1985 • 107 citations

An animal model for colon cancer metastasis: establishment and characterization of murine cell lines with enhanced liver-metastasizing ability.

1987 • 106 citations

Tumor cell diversity and host responses in cancer metastasis—Part I—Properties of metastatic cells

1982 • 103 citations

CYTOPROTECTIVE EFFECT OF PROSTAGLANDIN I2 ON ISCHEMIA-INDUCED HEPATIC CELL INJURY

1983 • 95 citations

Importance of Local Proliferation in the Expanding Kupffer Cell Population of Rat Liver After Zymosan Stimulation and Partial Hepatectomy

1984 • 94 citations

Differential inhibition of prostaglandin and superoxide production by dexamethasone in primary cultures of rat Kupffer cells

1986 • 90 citations

Early Events of the Immune Response Mediated by Leukocyte Integrins

1990 • 89 citations

Generation and characterization of a lipopolysaccharide-induced and serum-derived cytotoxic factor for tumor cells

1980 • 88 citations

Filtration effect of endothelial fenestrations on chylomicron transport in neonatal rat liver sinusoids

1978 • 85 citations

Random and nonrandom processes in metastasis, and metastatic inefficiency.

1983 • 84 citations

Filtration of chylomicrons by the liver may influence cholesterol metabolism and atherosclerosis

1978 • 83 citations

In vitro activation of rat liver macrophages to tumoricidal activity by free or liposome-encapsulated muramyl dipeptide.

1986 • 82 citations

Studies in vivo and in vitro on the uptake and degradation of soluble collagen α1(I) chains in rat liver endothelial and Kupffer cells

1985 • 77 citations

Induction of rat α₂‐macroglobulin in vivo and in hepatocyte primary cultures: synergistic action of glucocorticoids and a Kupffer cell‐derived factor

1984 • 76 citations

Increase in the number of fenestrae in mouse endothelial liver cells by altering the cytoskeleton with cytochalasin B

1987 • 72 citations

Cellular origin of collagen and fibronectin in the liver.

1984 • 71 citations

Local Proliferation and Extrahepatic Recruitment of Liver Macrophages (Kupffer Cells) in Partial-Body Irradiated Rats

1986 • 70 citations

Endocytosis and degradation of chondroitin sulphate by liver endothelial cells

1985 • 69 citations

Early alcoholic liver injury: changes of the Disse space in acinar zone 3

1985 • 64 citations

Proliferation, Kinetics, and Fate of Monocytes in Rat Liver During a Zymosan- Induced Inflammation

1985 • 63 citations

Liver as a tumor cell killing organ: Kupffer cells and natural killers.

1986 • 61 citations

Kupffer cells and liver metastasis

1989 • 58 citations

Interleukin-6 release by rat liver macrophages

1990 • 58 citations

Localization of factor VIIIC: antigen in guinea‐pig tissues and isolated liver cell fractions

1984 • 55 citations

Sinusoidal endothelial cells from guinea pig liver synthesize and secrete cellular fibronectin in vitro

1987 • 54 citations

Prostanoid release of cultured liver sinusoidal endothelial cells in response to endotoxin and tumor necrosis factor

1990 • 54 citations

DEFENESTRATION OF HEPATIC SINUSOIDS AS A CAUSE OF HYPERLIPOPROTEINAEMIA IN ALCOHOLICS

1988 • 54 citations

Correlation of Inhibition of Adhesion of Large Cell Lymphoma and Hepatic Sinusoidal Endothelial Cells by RGD-Containing Peptide Polymers with Metastatic Potential: Role of Integrin-Dependent and -Independent Adhesion Mechanisms

1989 • 53 citations

Ca2+ requirement of prostanoid but not of superoxide production by rat Kupffer cells

1988 • 53 citations

Identification of connective tissue gene transcripts in freshly isolated parenchymal, endothelial, Kupffer and fat-storing cells by Northern hybridization analysis

1993 • 52 citations

Sinusoidal Endothelial Cells from Normal Guinea Pig Liver: Isolation, Culture and Characterization†

1984 • 50 citations

Prostaglandin release but not superoxide production by rat Kupffer cells stimulated in vitro depends on Na⁺/H⁺ exchange

1987 • 50 citations

Leukotrienes as Mediators in Diseases of the Liver

1988 • 46 citations

Receptor-mediated endocytosis of ovalbumin by two carbohydrate-specific receptors in rat liver cells. The intracellular transport of ovalbumin to lysosomes is faster in liver endothelial cells than in parenchymal cells

1990 • 46 citations

Liver macrophages (Kupffer cells) as cytotoxic effector cells in extracellular and intracellular cytotoxicity

1985 • 41 citations

Secretion of coagulant factor VIII activity and antigen by in vitro cultivated rat liver sinusoidal endothelial cells

1989 • 38 citations

Ultrastructural studies of the portal transport of fat in chickens.

1986 • 38 citations

Hepatic sinusoidal endothelium: Ulex lectin binding

1989 • 36 citations

Natural Antitumor Defense System of the Murine Liver

1985 • 35 citations

The Effects of Hepatic Fibrosis on Ito Cell Gene Expression

1992 • 34 citations

Human Kupffer cells are cytotoxic against human colon adenocarcinoma

1990 • 34 citations

Endocytosis mediated by the mannose receptor in liver endothelial cells. An immunocytochemical study.

1990 • 33 citations

Morphological studies on endocytosis of chondroitin sulphate proteoglycan by rat liver endothelial cells

1988 • 33 citations

Enhancement of neutrophil adherence to isolated rat liver sinusoidal endothelial cells by supernatants of lipopolysaccharide-activated monocytes

1987 • 32 citations

Small liver fenestrae may explain the susceptibility of rabbits to atherosclerosis.

1983 • 32 citations

Uptake and degradation in vivo and in vitro of laminin and nidogen by rat liver cells

1989 • 32 citations

Nicotine decreases the porosity of the rat liver sieve: a possible mechanism for hypercholesterolaemia.

1988 • 31 citations

Hepatic protection by 16,16-dimethyl prostaglandin E2 (DMPG) against acute aflatoxin B1-induced injury in the rat

1989 • 30 citations

Peroxidase-positive endothelial cells in sinusoids of the mouse liver.

1978 • 28 citations

Protective effect of 16,16-dimethyl prostaglandin E2 on the hepatotoxicity of bromobenzene in mice

1984 • 27 citations

Decreased hepatic uptake of cholesterol and retinol in the dimethylnitrosamine rat model of cirrhosis

1992 • 25 citations

Expression of ABH blood group antigens, Ulex europaeus agglutinin I, and type IV collagen in the sinusoids of hepatocellular carcinoma.

1991 • 24 citations

Suppression of acute inflammation by 15 methyl prostaglandin E1.

1988 • 23 citations

Synergistic effect of magnesium and calcium ions in the activation of phospholipase A2 of liver macrophages

1991 • 22 citations

Adhesion of Tumor Cells to Hepatocytes: Different Mechanisms for Mammary Carcinoma Compared With Lymphosarcoma Cells

1984 • 20 citations

Effects of Various Cytokines on Collagen Synthesis by Normal Rat Hepatocytes in Primary Cultures and Fibroblasts

1989 • 20 citations

Peroxidase-positive endothelial cells in rat liver

1984 • 18 citations

Intracellular transport of endocytosed proteins in rat liver endothelial cells

1990 • 17 citations

Uptake and intracellular transport in rat liver of formaldehyde‐treated bovine serum albumin labelled with ¹²⁵I‐tyramine‐cellobiose

1988 • 16 citations

Cancer‐cell traffic in the liver. III. Lethal deformation of B16 melanoma cells in liver sinusoids

1993 • 15 citations

Human hepatic sinusoidal endothelial cells in culture produce von Willebrand factor and contain Weibel‐Palade bodies

1989 • 13 citations

Recent insights into the function of hepatic sinusoidal cells.

1987 • 12 citations

Adhesion molecules involved in the trafficking of normal and malignant leukocytes.

1992 • 12 citations

Ultrastructural studies of experimental endotoxin shock in the liver and spleen: therapeutic effects of low-dose heparin on reticuloendothelial disturbances.

1986 • 11 citations

Experimental studies on the effect of hepatoprotective compounds.

1986 • 11 citations

Management of metastatic prostatic cancer.

1988 • 9 citations

Ultrastructure and quantitative composition of isolated endothelial cells of rat liver

1990 • 8 citations