Role of Peroxynitrite as a Mediator of Pathophysiological Alterations in Experimental Pneumococcal Meningitis

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

1996 • 5,498 citations

Lipid peroxidation and antioxidants as biomarkers of tissue damage

1995 • 1,845 citations

Nitric Oxide Activation of Poly(ADP-Ribose) Synthetase in Neurotoxicity

1994 • 1,138 citations

Extensive Nitration of Protein Tyrosines in Human Atherosclerosis Detected by Immunohistochemistry

1994 • 1,138 citations

Increased 3‐nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis

1997 • 593 citations

Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis

1998 • 547 citations

Nitric Oxide‐Mediated Mitochondrial Damage in the Brain: Mechanisms and Implications for Neurodegenerative Diseases

1997 • 525 citations

Evidence for In Vivo Peroxynitrite Production in Human Acute Lung Injury

1995 • 491 citations

Activation of the inducible form of nitric oxide synthase in the brains of patients with multiple sclerosis.

1995 • 464 citations

Endothelial dysfunction in a rat model of endotoxic shock. Importance of the activation of poly (ADP-ribose) synthetase by peroxynitrite.

1997 • 368 citations

Prevention of experimental allergic encephalomyelitis by targeting nitric oxide and peroxynitrite: Implications for the treatment of multiple sclerosis

1997 • 337 citations

Quantitative Evaluation of Vascular Permeability in the Gerbil Brain after Transient Ischemia Using Evans Blue Fluorescence

1988 • 271 citations

Reactive oxygen intermediates contribute to necrotic and apoptotic neuronal injury in an infant rat model of bacterial meningitis due to group B streptococci.

1996 • 235 citations

Extensive tyrosine nitration in human myocardial inflammation

1997 • 233 citations

Matrix metalloproteinases contribute to the blood—brain barrier disruption during bacterial meningitis

1998 • 198 citations

Evidence for in vivo peroxynitrite production in human acute lung injury.

1995 • 193 citations

[19] Antibodies that recognize nitrotyrosine

1996 • 190 citations

Evidence for reactive nitrogen intermediates in killing of staphylococci by human neutrophil cytoplasts. A new microbicidal pathway for polymorphonuclear leukocytes.

1992 • 186 citations

Nitric oxide production and perivascular nitration in brain after carbon monoxide poisoning in the rat.

1996 • 174 citations

Inactivation of tissue inhibitor of metalloproteinase‐1 by peroxynitrite

1996 • 170 citations

Protection Against Peroxynitrite-Dependent Tyrosine Nitration and α₁-Antiproteinase Inactivation by Ascorbic Acid. A Comparison with other Biological Antioxidants

1996 • 169 citations

Extensive peroxynitrite activity during progressive stages of central nervous system inflammation

1997 • 157 citations

Experimental pneumococcal meningitis: Cerebrovascular alterations, brain edema, and meningeal inflammation are linked to the production of nitric oxide

1995 • 153 citations

Microvascular Changes during the Early Phase of Experimental Bacterial Meningitis

1990 • 136 citations

Inducible Nitric Oxide Synthase and the Effect of Aminoguanidine in Experimental Neonatal Meningitis

1998 • 116 citations

Oxidative Stress in Bacterial Meningitis

1999 • 109 citations

Potential role of nitric oxide in the pathophysiology of experimental bacterial meningitis in rats

1995 • 87 citations

Human Matrix Metalloprotease Activation by Insults of Bacterial Infection Involving Proteases and Free Radicals

1998 • 86 citations

Neurotoxicity of glia activated by gram-positive bacterial products depends on nitric oxide production

1996 • 86 citations

Early microvascular changes in murine cerebral malaria detected in retinal wholemounts.

1992 • 80 citations

Nitric Oxide Production and Perivascular Tyrosine Nitration Following Focal Ischemia in Neonatal Rat

1998 • 71 citations

Transforming growth factor beta 2 inhibits cerebrovascular changes and brain edema formation in the tumor necrosis factor alpha-independent early phase of experimental pneumococcal meningitis.

1992 • 66 citations

Protective effect of the antioxidant N-acetyl-l-cysteine in pneumococcal meningitis in the rat

1997 • 66 citations

Oxygen Free Radicals and the Cerebral Arteriolar Response to Group B Streptococci

1992 • 51 citations

New Perspectives on Bacterial Meningitis

1993 • 45 citations

Nitric oxide synthase-expressing neurons are area-specifically distributed within the cerebral cortex of the rat

1997 • 45 citations

Is nitric oxide involved as a mediator of cerebrovascular changes in the early phase of experimental pneumococcal meningitis?

1994 • 40 citations

Superoxide production by primary rat cerebral endothelial cells in response to pneumococci

1999 • 34 citations

Production of nitrite by primary rat astrocytes in response to pneumococci

1995 • 30 citations

Levels of Nitric Oxide Correlate with High Levels of Tumor Necrosis Factor in Cerebrospinal Fluid Samples from Children with Bacterial Meningitis

1996 • 24 citations

Protective Effect of a 21-Aminosteroid during Experimental Pneumococcal Meningitis

1995 • 24 citations

Detection of Brain Free Oxygen Radical Generated Photons in Vivo: Preliminary Results

1993 • 11 citations

OXYGEN RADICAL SCAVENGERS PREVENT IMPAIRMENT OF MICROVASCULAR AUTOREGULATION IN HEMOPHILUSINFLUENZAE TYPE B MENINGITIS IN RATS

1993 • 3 citations