MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites

ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage

2007 • 2,956 citations

RNF8 Ubiquitylates Histones at DNA Double-Strand Breaks and Promotes Assembly of Repair Proteins

2007 • 1,133 citations

A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin

2004 • 1,073 citations

MDC1 Directly Binds Phosphorylated Histone H2AX to Regulate Cellular Responses to DNA Double-Strand Breaks

2005 • 1,036 citations

RNF8 Transduces the DNA-Damage Signal via Histone Ubiquitylation and Checkpoint Protein Assembly

2007 • 988 citations

BRCA2 Is Required for Homology-Directed Repair of Chromosomal Breaks

2001 • 980 citations

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

2003 • 968 citations

Structural Basis for the Methylation State-Specific Recognition of Histone H4-K20 by 53BP1 and Crb2 in DNA Repair

2006 • 945 citations

Orchestration of the DNA-Damage Response by the RNF8 Ubiquitin Ligase

2007 • 862 citations

MDC1 is a mediator of the mammalian DNA damage checkpoint

2003 • 862 citations

The BRCT Domain Is a Phospho-Protein Binding Domain

2003 • 821 citations

BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

2003 • 644 citations

MDC1 Maintains Genomic Stability by Participating in the Amplification of ATM-Dependent DNA Damage Signals

2006 • 601 citations

PR-Set7 Is a Nucleosome-Specific Methyltransferase that Modifies Lysine 20 of Histone H4 and Is Associated with Silent Chromatin

2002 • 571 citations

53BP1, a Mediator of the DNA Damage Checkpoint

2002 • 559 citations

The t(4;14) Translocation in Myeloma Dysregulates Both FGFR3and a Novel Gene, MMSET, Resulting in IgH/MMSET Hybrid Transcripts

1998 • 555 citations

Methylation of Histone H4 Lysine 20 Controls Recruitment of Crb2 to Sites of DNA Damage

2004 • 542 citations

DBC1 is a negative regulator of SIRT1

2008 • 483 citations

A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse

2008 • 414 citations

A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf–Hirschhorn syndrome

2009 • 353 citations

Purification and Functional Characterization of SET8, a Nucleosomal Histone H4-Lysine 20-Specific Methyltransferase

2002 • 321 citations

WHSC1, a 90 kb SET Domain-Containing Gene, Expressed in Early Development and Homologous to a Drosophila Dysmorphy Gene Maps in the Wolf-Hirschhorn Syndrome Critical Region and is Fused to IgH in t(1;14) Multiple Myeloma

1998 • 315 citations

Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1

2005 • 276 citations

CtIP Links DNA Double-Strand Break Sensing to Resection

2009 • 216 citations

The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor

2007 • 198 citations

The etiology of Wolf?Hirschhorn syndrome

2005 • 183 citations

Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks

2006 • 141 citations

53BP1: function and mechanisms of focal recruitment

2009 • 137 citations

Structure of the BRCT Repeat Domain of MDC1 and Its Specificity for the Free COOH-terminal End of the γ-H2AX Histone Tail

2005 • 123 citations

Multiple Myeloma-Related WHSC1/MMSET Isoform RE-IIBP Is a Histone Methyltransferase with Transcriptional Repression Activity

2008 • 98 citations