RNF8 Transduces the DNA-Damage Signal via Histone Ubiquitylation and Checkpoint Protein Assembly

ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage

2007 • 2,956 citations

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

2005 • 2,633 citations

RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO

2002 • 2,139 citations

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

2000 • 2,052 citations

HKL-3000: the integration of data reduction and structure solution – from diffraction images to an initial model in minutes

2006 • 1,976 citations

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

2005 • 1,975 citations

Interaction of the Fanconi Anemia Proteins and BRCA1 in a Common Pathway

2001 • 1,206 citations

Likelihood-enhanced fast rotation functions

2004 • 1,182 citations

RNF8 Ubiquitylates Histones at DNA Double-Strand Breaks and Promotes Assembly of Repair Proteins

2007 • 1,133 citations

MDC1 Directly Binds Phosphorylated Histone H2AX to Regulate Cellular Responses to DNA Double-Strand Breaks

2005 • 1,036 citations

Structural Basis for the Methylation State-Specific Recognition of Histone H4-K20 by 53BP1 and Crb2 in DNA Repair

2006 • 945 citations

MDC1 is a mediator of the mammalian DNA damage checkpoint

2003 • 862 citations

Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

2004 • 859 citations

Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation

2003 • 833 citations

The BRCT Domain Is a Phospho-Protein Binding Domain

2003 • 821 citations

Noncanonical MMS2-Encoded Ubiquitin-Conjugating Enzyme Functions in Assembly of Novel Polyubiquitin Chains for DNA Repair

1999 • 814 citations

Histone H2B Monoubiquitination Functions Cooperatively with FACT to Regulate Elongation by RNA Polymerase II

2006 • 688 citations

Abraxas and RAP80 Form a BRCA1 Protein Complex Required for the DNA Damage Response

2007 • 678 citations

RAP80 Targets BRCA1 to Specific Ubiquitin Structures at DNA Damage Sites

2007 • 660 citations

DNA damage-induced G2–M checkpoint activation by histone H2AX and 53BP1

2002 • 653 citations

BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

2003 • 644 citations

MDC1 Maintains Genomic Stability by Participating in the Amplification of ATM-Dependent DNA Damage Signals

2006 • 601 citations

Histone acetylation by Trrap–Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks

2005 • 579 citations

H2AX Haploinsufficiency Modifies Genomic Stability and Tumor Susceptibility

2003 • 545 citations

Methylation of Histone H4 Lysine 20 Controls Recruitment of Crb2 to Sites of DNA Damage

2004 • 542 citations

Ubiquitin-Binding Protein RAP80 Mediates BRCA1-Dependent DNA Damage Response

2007 • 525 citations

MDC1 is required for the intra-S-phase DNA damage checkpoint

2003 • 508 citations

Histone H3 and H4 Ubiquitylation by the CUL4-DDB-ROC1 Ubiquitin Ligase Facilitates Cellular Response to DNA Damage

2006 • 491 citations

Histone H2AX

2003 • 479 citations

Convergence of the Fanconi Anemia and Ataxia Telangiectasia Signaling Pathways

2002 • 458 citations

The Molecular Basis of FHA Domain:Phosphopeptide Binding Specificity and Implications for Phospho-Dependent Signaling Mechanisms

2000 • 449 citations

Chromatin remodelling at a DNA double-strand break site in Saccharomyces cerevisiae

2005 • 420 citations

Rad53 FHA Domain Associated with Phosphorylated Rad9 in the DNA Damage Checkpoint

1998 • 392 citations

DNA Damage-Induced Cell Cycle Checkpoint Control Requires CtIP, a Phosphorylation-Dependent Binding Partner of BRCA1 C-Terminal Domains

2004 • 391 citations

Accumulation of Checkpoint Protein 53BP1 at DNA Breaks Involves Its Binding to Phosphorylated Histone H2AX

2003 • 354 citations

MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

2003 • 332 citations

The DDB1-CUL4A ^DDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites

2006 • 318 citations

BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP

2006 • 276 citations

Regulation of DNA repair by ubiquitylation

2006 • 270 citations

BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair

2004 • 255 citations

Structural and Functional Versatility of the FHA Domain in DNA-Damage Signaling by the Tumor Suppressor Kinase Chk2

2002 • 228 citations

A Critical Role for the Ubiquitin-Conjugating Enzyme Ubc13 in Initiating Homologous Recombination

2007 • 218 citations

Chfr is required for tumor suppression and Aurora A regulation

2005 • 194 citations

The FHA domain mediates phosphoprotein interactions

2000 • 162 citations

A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites

2006 • 148 citations

A FancD2-Monoubiquitin Fusion Reveals Hidden Functions of Fanconi Anemia Core Complex in DNA Repair

2005 • 139 citations

Mediator of DNA Damage Checkpoint Protein 1 Regulates BRCA1 Localization and Phosphorylation in DNA Damage Checkpoint Control

2003 • 136 citations

N‐Terminally extended human ubiquitin‐conjugating enzymes (E2s) mediate the ubiquitination of RING‐finger proteins, ARA54 and RNF8

2001 • 99 citations

The RING finger protein RNF8 recruits UBC13 for lysine 63‐based self polyubiquitylation

2005 • 93 citations

The RING Finger Protein, RNF8, Interacts with Retinoid X Receptor α and Enhances Its Transcription-stimulating Activity

2004 • 39 citations