Anergic B cells constitutively present self antigen: Enhanced immunoglobulin receptor‐mediated presentation of antigenic determinants by B cells is hierarchical

Bone Marrow Transplant

1990 • 2,745 citations

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

1987 • 1,644 citations

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice

1988 • 1,562 citations

Antigen-specific interaction between T and B cells

1985 • 1,396 citations

Characterization of the Murine Antigenic Determinant, Designated L3T4a, Recognized by Monoclonal Antibody GK 1.5: Expression of L3T4a by Functional T Cell Clones Appears to Correlate Primarily with Class II MHC Antigen‐Reactivity

1983 • 1,040 citations

Receptor editing in self-reactive bone marrow B cells.

1993 • 1,026 citations

Properties of Monoclonal Antibodies to Mouse Ig Allotypes, H-2, and Ia Antigens

1979 • 993 citations

Receptor editing: an approach by autoreactive B cells to escape tolerance.

1993 • 920 citations

Receptor-Mediated Antigen Uptake and its Effect on Antigen Presentation to Class II-Restricted T Lymphocytes

1990 • 605 citations

Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens

1978 • 589 citations

B Cells Turn Off Virgin But Not Memory T Cells

1992 • 578 citations

A monoclonal antibody discriminating between subsets of T and B cells.

1981 • 565 citations

Induction of self-tolerance in mature peripheral B lymphocytes

1989 • 525 citations

Surface Antigen Expression and Immunoglobulin Gene Rearrangement During Mouse pre‐B Cell Development

1983 • 490 citations

Small B cells as antigen-presenting cells in the induction of tolerance to soluble protein antigens.

1992 • 435 citations

Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors.

1984 • 422 citations

The antigen-specific, major histocompatibility complex-restricted receptor on T cells. VI. An antibody to a receptor allotype.

1984 • 389 citations

Differential regulation of metallothionein-thymidine kinase fusion genes in transgenic mice and their offspring

1982 • 379 citations

Monoclonal cytolytic T-cell lines.

1979 • 364 citations

Lymphocyte specificity to protein antigens. I. Characterization of the antigen-induced in vitro T cell-dependent proliferative response with lymph node cells from primed mice.

1977 • 361 citations

Interspecies spleen-myeloma hybrid producing monoclonal antibodies against mouse lymphocyte surface glycoprotein, T200.

1978 • 282 citations

Efficient and selective presentation of antigen-antibody complexes by rheumatoid factor B cells.

1991 • 278 citations

Differential requirements for antigen processing by macrophages for lysozyme-specific T cell hybridomas.

1984 • 272 citations

Breakdown of self-tolerance in anergic B lymphocytes

1991 • 254 citations

The Choice of T‐Cell Epitopes Utilized on a Protein Antigen Depends on Multiple Factors Distant from, as well as at the Determinant Site

1987 • 247 citations

Reduction of disulfide bonds within lysosomes is a key step in antigen processing.

1991 • 245 citations

Mechanisms influencing the immunodominance of T cell determinants.

1988 • 227 citations

Tolerance to a self-protein involves its immunodominant but does not involve its subdominant determinants.

1992 • 219 citations

Effect of antigen/antibody ratio on macrophage uptake, processing, and presentation to T cells of antigen complexed with polyclonal antibodies.

1991 • 212 citations

Distinct mechanisms of neonatal tolerance induced by dendritic cells and thymic B cells.

1991 • 187 citations

The Evolution of B-Cell Clones

1990 • 185 citations

Antigen presentation by resting B cells. Radiosensitivity of the antigen-presentation function and two distinct pathways of T cell activation.

1984 • 182 citations

Mapping Epitopes on a Protein Antigen by the Proteolysis of Antigen-Antibody Complexes

1986 • 175 citations

Lymphocyte Specificity to Protein Antigens

1977 • 175 citations

Suppressive effect of antibody on processing of T cell epitopes.

1993 • 166 citations

Epitope-directed processing of specific antigen by B lymphocytes.

1989 • 163 citations

Control of the Immune Response at the Level of Antigen-Presenting Cells: A Comparison of the Function of Dendritic Cells and B Lymphocytes

1989 • 163 citations

Antigen Uptake and Accumulation in Antigen‐Specific B Cells

1987 • 148 citations

Development and follicular localization of tolerant B lymphocytes in lysozyme/anti-lysozyme lgM/lgD transgenic mice

1992 • 147 citations

Antigenic regions defined by monoclonal antibodies correspond to structural domains of avian lysozyme.

1984 • 131 citations

Allotypic specificities of murine IgD and IgM recognized by monoclonal antibodies.

1984 • 116 citations

Differential activation of T cell clones stimulated by macrophages exposed to antigen complexed with monoclonal antibodies. A possible influence of paratope specificity on the mode of antigen processing.

1988 • 115 citations

Monoclonal anti‐allotype antibody towards BALB/c IgM Analysis of specificity and site of a V‐C crossover in recombinant strain BALB‐Igh‐V^a/Igh‐C^b

1987 • 104 citations

Antibody conjugates mimic specific B cell presentation of antigen: relationship between T and B cell specificity.

1987 • 103 citations

Antigen presentation by the B cell antigen receptor is driven by the αβ sheath and occurs independently of its cytoplasmic tyrosines

1993 • 101 citations

Constraints in T‐B cooperation related to epitope topology on E. coli β‐galactosidase. I. The fine specificity of T cells dictates the fine specificity of antibodies directed to conformation‐ dependent determinants

1985 • 97 citations

Effect of monoclonal antibodies on limited proteolysis of native glycoprotein gD of herpes simplex virus type 1

1982 • 96 citations

Targeting autoantigen to B cells prevents the induction of a cell-mediated autoimmune disease in rats.

1992 • 94 citations

Targeted antigen presentation using crosslinked antibody heteroaggregates.

1987 • 93 citations

Intrinsic B-cell hyporesponsiveness accounts for self-tolerance in lysozyme/anti-lysozyme double-transgenic mice.

1990 • 92 citations

Class II-restricted presentation of an endogenously derived immunodominant T-cell determinant of hen egg lysozyme.

1991 • 89 citations

Antigen presentation by hapten-specific B lymphocytes. II. Specificity and properties of antigen-presenting B lymphocytes, and function of immunoglobulin receptors.

1985 • 87 citations

Endocytosis, intracellular trafficking, and processing of membrane IgG and monovalent antigen/membrane IgG complexes in B lymphocytes.

1990 • 85 citations

Enhancement of antigenic potency in vitro and immunogenicity in vivo by coupling the antigen to anti-immunoglobulin.

1986 • 85 citations

Parameters of tolerance induction by antigen targeted to B lymphocytes.

1993 • 73 citations

Antigen-specific B cells efficiently present low doses of antigen for induction of T cell proliferation.

1985 • 72 citations

Monoclonal antibodies to the murine Ly-2.1 cell surface antigen.

1982 • 70 citations

Exogenous peptides compete for the presentation of endogenous antigens to major histocompatibility complex class II-restricted T cells.

1991 • 60 citations

Efficiency of antigen presentation after antigen targeting to surface IgD, IgM, MHC, Fc gamma RII, and B220 molecules on murine splenic B cells.

1989 • 60 citations

Activation of human B lymphocytes: frequency of antigen‐specific B cells triggered by alloreactive or by antigen‐specific T cell clones

1983 • 56 citations

Enhanced T cell responses to antigenic peptides targeted to B cell surface Ig, Ia, or class I molecules.

1988 • 54 citations

Manual of macrophage methodology : collection, characterization, and function

1981 • 50 citations

T cell receptor gene segment usage in a panel of hen-egg white lysozyme specific, I-Ak-restricted T helper hybridomas.

1989 • 48 citations

Involvement of Lyt-2 and L3T4 in activation of hapten-specific Lyt-2+ L3T4+ T-cell clones.

1986 • 47 citations

Differential sensitivity of specific and nonspecific antigen-presentation by B cells to a protein synthesis inhibitor.

1990 • 44 citations

Capacity of B cells to function as stimulators of a primary mixed leukocyte reaction.

1986 • 41 citations

Time dependence of B cell processing and presentation of peptide and native protein antigens.

1988 • 41 citations

Clonal Silencing of Self-reactive B Lymphocytes in a Transgenic Mouse Model

1989 • 36 citations

Antigen Presentation by B Lymphocytes: A Critical Step in T-B Collaboration

1986 • 32 citations

Antigen presentation by hapten-specific B lymphocytes. IV. Comparative ability of B cells to present specific antigen and anti-immunoglobulin antibody.

1987 • 27 citations

Markers of macrophage heterogeneity. I. Studies of macrophages from various organs of normal mice

1979 • 24 citations

Aberrant induction of T cell tolerance in B cell suppressed mice.

1993 • 24 citations

Analysis of proteolytic processing during specific antigen presentation

1987 • 21 citations

Intrathymic presentation of nominal antigen by B cells

1990 • 19 citations

Antigen presentation by hapten‐specific B lymphocytes III. Analysis of the immunoglobulin‐dependent pathway of antigen presentation to interleukin 1‐dependent T lymphocytes

1986 • 17 citations

Inhibition by brefeldin A of the specific B cell antigen presentation to MHC class II-restricted T cells.

1991 • 16 citations

Threshold detection of self-antigen/MHC class II complexes formed in vivo: constitutive presentation of an immunodominant epitope of hen egg lysozyme (HEL) in HEL-transgenic mice

1993 • 11 citations