Phosphatidylinositol-3-kinase is a non-tyrosine phosphorylated member of the insulin receptor signalling complex

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Oncogenes and signal transduction

1991 • 2,816 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1991 • 1,590 citations

Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

1988 • 1,027 citations

Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells

1985 • 665 citations

cDNA cloning of a Novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptor

1991 • 585 citations

Role of Phosphatidylinositol Kinase in PDGF Receptor Signal Transduction

1989 • 516 citations

Recent progress in characterization of protein kinase cascades for phosphorylation of ribosomal protein S6

1991 • 442 citations

The insulin receptor and the molecular mechanism of insulin action.

1988 • 426 citations

The Insulin Receptor: Molecular Biology and Transmembrane Signaling*

1987 • 285 citations

Phosphatidylinositol kinase or an associated protein is a substrate for the insulin receptor tyrosine kinase.

1990 • 266 citations

Phosphorylation of the PDGF receptor beta subunit creates a tight binding site for phosphatidylinositol 3 kinase.

1990 • 244 citations

Phosphatidylinositol kinase activity associates with viral p60src protein.

1989 • 194 citations

Interactions of phosphatidylinositol kinase, GTPase-activating protein (GAP), and GAP-associated proteins with the colony-stimulating factor 1 receptor.

1990 • 167 citations

Phosphatidylinositol-3-kinase in isolated rat adipocytes. Activation by insulin and subcellular distribution.

1992 • 137 citations

Insulin and insulinomimetic agents induce activation of phosphatidylinositol 3'-kinase upon its association with pp185 (IRS-1) in intact rat livers.

1992 • 125 citations

Hepatocyte plasma membrane ecto-ATPase (pp120HA4) is a substrate for tyrosine kinase activity of the insulin receptor

1990 • 108 citations

The insulin receptor-related receptor. Tissue expression, ligand binding specificity, and signaling capabilities.

1992 • 99 citations

Modification of the 85-kilodalton subunit of phosphatidylinositol-3 kinase in platelet-derived growth factor-stimulated cells.

1992 • 88 citations

Insulin receptor monoclonal antibodies that mimic insulin action without activating tyrosine kinase

1989 • 76 citations

Monoclonal Antibodies Mimic Insulin Activation of Ribosomal Protein S6 Kinase without Activation of Insulin Receptor Tyrosine Kinase

1989 • 47 citations

Substrates and signalling complexes: The tortured path to insulin action

1992 • 30 citations

Insulin receptor signaling through non‐tyrosine kinase pathways: Evidence from anti‐receptor antibodies and insulin receptor mutants

1992 • 19 citations