Relationship between in vivo degradative rates and isoelectric points of proteins.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Intracellular Protein Degradation in Mammalian and Bacterial Cells

1974 • 1,775 citations

The Roles of Synthesis and Degradation in the Control of Rat Liver Tryptophan Pyrrolase

1965 • 592 citations

Studies on the Synthesis and Degradation of Proteins of the Endoplasmic Reticulum of Rat Liver

1969 • 538 citations

Regulation of Synthesis and Turnover of Ferritin in Rat Liver

1966 • 329 citations

Degradation of Abnormal Proteins in Escherichia coli

1972 • 298 citations

Protein Turnover in Skeletal Muscle

1969 • 220 citations

Proinsulin and the Biosynthesis of Insulin

1969 • 208 citations

Size Distribution of Membrane Proteins of Rat Liver and Their Relative Rates of Degradation

1971 • 192 citations

Studies of the Stability in Vivo and in Vitro of Rat Liver Tryptophan Pyrrolase

1965 • 169 citations

Studies on the Correlation between Size and Relative Degradation Rate of Soluble Proteins

1973 • 165 citations

On the Measurement of Protein Turnover in Animal Cells

1972 • 162 citations

Proparathyroid Hormone: Identification of a Biosynthetic Precursor to Parathyroid Hormone

1972 • 162 citations

The Kinetics of Disappearance of Labeled Leucine from the Free Leucine Pool and Rat Liver and Its Effect on the Apparent Turnover of Catalase and Other Hepatic Proteins

1971 • 158 citations

In vivo Degradation of Nonsense Fragments in E. coli

1970 • 156 citations

Degradation of abnormal proteins in Escherichia coli. Formation of protein inclusions in cells exposed to amino acid analogs.

1975 • 148 citations

Turnover and Exchange of Ribosomal Proteins from Rat Liver

1972 • 130 citations

β-Glucuronidase of Rat Liver Lysosomes

1971 • 129 citations

Studies on ornithine decarboxylase from the liver of thioacetamide-treated rats Purification and some properties

1972 • 125 citations

Heterogeneity of Presumably Homogeneous Protein Preparations

1969 • 121 citations

In vivo Degradation of Mutant Lac Repressor

1970 • 116 citations

Response of Intracellular Proteolysis to Alteration of Bacterial Protein and the Implications in Metabolic Regulation

1967 • 112 citations

β-Galactosidase

1972 • 112 citations

SMALL‐SCALE FRACTIONATION OF PROTEINS AND NUCLEIC ACIDS BY ISOELECTRIC FOCUSING IN POLYACRYLAMIDE GELS*

1973 • 111 citations

The Relation of Size to the Relative Rates of Degradation of Intestinal Brush Border Proteins

1972 • 94 citations

Mechanism of allylisopropylacetamide-induced increase of δ-aminolevulinate synthetase in liver mitochondria

1969 • 92 citations

Coenzyme dissociation, a possible determinant of short half-life of inducible enzymes in mammalian liver

1973 • 81 citations

Effect of size on the relative rate of degradation of rat liver soluble proteins

1970 • 79 citations

Comparative physical-chemical studies of mammalian arginases

1970 • 76 citations

Correlation Between Rates of Degradation of Bacterial Proteins In Vivo and Their Sensitivity to Proteases

1972 • 74 citations

The Glyceraldehyde 3-Phosphate Dehydrogenases of Liver and Muscle

1972 • 65 citations

A comparison of the proteolytic susceptibility of several rat liver enzymes

1971 • 63 citations

Relative Rates of Degradation of Mouse‐Liver Surface‐Membrane Proteins

1973 • 63 citations

Structural and Functional Similarities Between Mitochondrial Malate Dehydrogenase and L-3-Hydroxyacyl CoA Dehydrogenase

1974 • 53 citations

Phosphopyruvate carboxylase induction by <scp>l</scp>-tryptophan. Effects on synthesis and degradation of the enzyme

1973 • 52 citations

A new pyruvate kinase isozyme in hepatomas

1969 • 51 citations

Adaptive Responses of Mammalian Histidine-degrading Enzymes

1970 • 51 citations

Turnover studies on proteins of rat liver lysosomes.

1975 • 49 citations

Rat serum albumin biosynthesis: Evidence for a precursor

1973 • 46 citations

Physiological significance of protein degradation in animal and bacterial cells.

1974 • 45 citations

What determines the half-life of proteins in, vivo? Some experiences with alanine aminotransferase of rat tissues

1969 • 42 citations

Lactate dehydrogenase isoenzymes. Turnover in rat heart, skeletal muscle, and liver

1973 • 37 citations

Turnover of chromosomal proteins from rat liver

1973 • 34 citations

Purification and characterization of mouse kidney beta-glucuronidase.

1975 • 33 citations

Relative turnover rates of subunits of rat liver fatty acid synthetase

1972 • 31 citations

The identity of the aldolases isolated from rat muscle and primary hepatoma

1970 • 29 citations

Purification and some properties of cytoplasmic aspartate aminotransferase from sheep liver

1973 • 28 citations

Rapid turnover of newly-synthesized βS chains in reticulocytes from individuals with sickle cell trait

1974 • 25 citations

Studies on soluble and mitochondrial tyrosine aminotransferase: Evidence for a physical change in the cytosol enzyme during induction

1969 • 25 citations

Avian fructose-1,6-diphosphatases

1972 • 18 citations

Further Characterization of a Glucagon Precursor from Anglerfish Islet Tissue

1973 • 17 citations

Effect of an inhibitor of proteolysis on the size of newly-synthesized protein in HeLa cells

1973 • 16 citations

Degradation of Poliovirus Polypeptides in vivo

1972 • 15 citations

MULTIPLE FORMS OF MAMMALIAN RNA POLYMERASE DISPLAYED BY GEL ELECTROFOCUSJNG

1973 • 14 citations

A study of glucose and xylose oxidation catalyzed by the glucose-6-phosphate dehydrogenase of rat liver cytosol

1972 • 13 citations

Separation of soluble and particulate mouse liver catalase by isoelectric focusing

1970 • 13 citations

Turnover of Lysosomal Proteins and Induction and Distribution of Rat Liver Proteinases, after Treatment with Triton WR-1339

1975 • 13 citations

Isoelectric pH of hemoglobin and cytochrome c by electrofocusing

1970 • 12 citations

A New Cyclic Dipeptide from Peptone

1960 • 12 citations

Immunological Quantitation of Hepatic Tryptophan Oxygenase in Endotoxin-Poisoned Mice

1973 • 11 citations