Characterization of Chemokine Receptor Utilization of Viruses in the Latent Reservoir for Human Immunodeficiency Virus Type 1

Homozygous Defect in HIV-1 Coreceptor Accounts for Resistance of Some Multiply-Exposed Individuals to HIV-1 Infection

1996 • 3,106 citations

Identification of a Reservoir for HIV-1 in Patients on Highly Active Antiretroviral Therapy

1997 • 2,989 citations

Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene

1996 • 2,883 citations

Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene

1996 • 2,502 citations

CHEMOKINE RECEPTORS AS HIV-1 CORECEPTORS: Roles in Viral Entry, Tropism, and Disease

1999 • 2,174 citations

Recovery of Replication-Competent HIV Despite Prolonged Suppression of Plasma Viremia

1997 • 2,154 citations

Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy

1999 • 2,083 citations

Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection

1997 • 2,011 citations

Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy

1997 • 1,911 citations

A Dual-Tropic Primary HIV-1 Isolate That Uses Fusin and the β-Chemokine Receptors CKR-5, CKR-3, and CKR-2b as Fusion Cofactors

1996 • 1,868 citations

HIV-1 entry into quiescent primary lymphocytes: Molecular analysis reveals a labile, latent viral structure

1990 • 1,560 citations

Change in Coreceptor Use Correlates with Disease Progression in HIV-1–Infected Individuals

1997 • 1,373 citations

Vpr Is Required for Efficient Replication of Human Immunodeficiency Virus Type-1 in Mononuclear Phagocytes

1995 • 1,252 citations

Effects of CCR5 and CD4 Cell Surface Concentrations on Infections by Macrophagetropic Isolates of Human Immunodeficiency Virus Type 1

1998 • 1,202 citations

The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes

1997 • 1,124 citations

Contingent Genetic Regulatory Events in T Lymphocyte Activation

1989 • 1,108 citations

Quantifying Residual HIV-1 Replication in Patients Receiving Combination Antiretroviral Therapy

1999 • 824 citations

Early establishment of a pool of latently infected, resting CD4 ⁺ T cells during primary HIV-1 infection

1998 • 811 citations

HIV-1 replication is controlled at the level of T cell activation and proviral integration.

1990 • 800 citations

In vivo fate of HIV-1-infected T cells: Quantitative analysis of the transition to stable latency

1995 • 755 citations

CCR5 Levels and Expression Pattern Correlate with Infectability by Macrophage-tropic HIV-1, In Vitro

1997 • 722 citations

Lifespan of human lymphocyte subsets defined by CD45 isoforms

1992 • 642 citations

Active nuclear import of human immunodeficiency virus type 1 preintegration complexes.

1992 • 604 citations

Human immunodeficiency virus type 1 preintegration complexes: studies of organization and composition

1997 • 600 citations

Quiescent T Lymphocytes as an Inducible Virus Reservoir in HIV-1 Infection

1991 • 584 citations

Reservoirs for HIV-1: Mechanisms for Viral Persistence in the Presence of Antiviral Immune Responses and Antiretroviral Therapy

2000 • 528 citations

A synthetic peptide inhibitor of human immunodeficiency virus replication: correlation between solution structure and viral inhibition.

1992 • 482 citations

Cytokine Signals Are Sufficient for HIV-1 Infection of Resting Human T Lymphocytes

1999 • 428 citations

Incompletely reverse-transcribed human immunodeficiency virus type 1 genomes in quiescent cells can function as intermediates in the retroviral life cycle

1992 • 399 citations

Progression to the G₁b Phase of the Cell Cycle Is Required for Completion of Human Immunodeficiency Virus Type 1 Reverse Transcription in T Cells

1998 • 312 citations

Chemokine Receptor Responses on T Cells Are Achieved Through Regulation of Both Receptor Expression and Signaling

1999 • 281 citations

In vivo estimates of division and death rates of human T lymphocytes.

1995 • 276 citations

In vivoHIV-1 infection of CD45RA⁺CD4⁺T cells is established primarily by syncytium-inducing variants and correlates with the rate of CD4⁺T cell decline

2000 • 259 citations

Integration of human immunodeficiency virus type 1 DNA in vitro.

1990 • 257 citations

Partial reverse transcripts in virions from human immunodeficiency and murine leukemia viruses

1992 • 221 citations

Host Control of HIV-1 Parasitism in T Cells by the Nuclear Factor of Activated T Cells

1998 • 221 citations

Both Memory and CD45RA⁺/CD62L⁺Naive CD4⁺T Cells Are Infected in Human Immunodeficiency Virus Type 1-Infected Individuals

1999 • 217 citations

Viral DNA carried by human immunodeficiency virus type 1 virions

1992 • 179 citations

Evidence that T cell activation is required for HIV-1 entry in CD4+ lymphocytes.

1989 • 177 citations

Cloning and analysis of the promoter region of CCR5, a coreceptor for HIV-1 entry.

1997 • 160 citations

HIV does not replicate in naive CD4 T cells stimulated with CD3/CD28.

1997 • 125 citations

CD45RC Isoforms Define Two Types of CD4 Memory T Cells, One of which Depends on Persisting Antigen

1997 • 125 citations

Loss of Inducible Virus in CD45RA Naive Cells After Human Immunodeficiency Virus-1 Entry Accounts for Preferential Viral Replication in CD45RO Memory Cells

1997 • 88 citations

Reverse Transcription Takes Place within Extracellular HIV-1 Virions: Potential Biological Significance

1993 • 88 citations

Highly purified quiescent human peripheral blood CD4+ T cells are infectible by human immunodeficiency virus but do not release virus after activation

1995 • 87 citations

Differential susceptibility of naive and memory CD4+ T cells to the cytopathic effects of infection with human immunodeficiency virus type 1 strain LAI

1997 • 80 citations

Highly purified CD25⁻resting T cells cannot be infectedde novowith HIV-1

1997 • 79 citations

Gene Organization and Promoter Function for CC Chemokine Receptor 5 (CCR5)

1998 • 54 citations

Intravirion reverse transcripts in the peripheral blood plasma on human immunodeficiency virus type 1-infected individuals

1994 • 51 citations

HIV infection of CD45RA+ and CD45RO+ CD4+ T cells

1997 • 46 citations

Nascent human immunodeficiency virus type 1 reverse transcription occurs within an enveloped particle

1995 • 26 citations

Loss of Inducible Virus in CD45RA Naive Cells After Human Immunodeficiency Virus-1 Entry Accounts for Preferential Viral Replication in CD45RO Memory Cells

1997 • 18 citations