Molecular Consequences of the BCR-ABL Translocation in Chronic Myelogenous Leukemia

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Induction of Chronic Myelogenous Leukemia in Mice by the P210 ^bcr/abl Gene of the Philadelphia Chromosome

1990 • 2,207 citations

Tyrosine Kinase Activity and Transformation Potency of bcr-abl Oncogene Products

1990 • 1,305 citations

The Molecular Genetics of Philadelphia Chromosome–Positive Leukemias

1988 • 867 citations

Acute leukaemia in bcr/abl transgenic mice

1990 • 701 citations

Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL.

1990 • 535 citations

Bcr encodes a GTPase-activating protein for p21rac

1991 • 474 citations

The mouse type IV c-abl gene product is a nuclear protein, and activation of transforming ability is associated with cytoplasmic localization

1989 • 427 citations

Dominant negative MYC blocks transformation by ABL oncogenes

1992 • 410 citations

BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias.

1991 • 392 citations

In vitro transformation of immature hematopoietic cells by the P210 BCR/ABL oncogene product of the Philadelphia chromosome.

1987 • 380 citations

BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner

1991 • 375 citations

Cell Cycle—Regulated Binding of c-Abl Tyrosine Kinase to DNA

1992 • 202 citations

The ABL-BCR fusion gene is expressed in chronic myeloid leukemia

1993 • 183 citations

Activation of the c-abl oncogene by viral transduction or chromosomal translocation generates altered c-abl proteins with similar in vitro kinase properties.

1985 • 162 citations

The ABL-BCR fusion gene is expressed in chronic myeloid leukemia

1993 • 150 citations

Alternative forms of the BCR-ABL oncogene have quantitatively different potencies for stimulation of immature lymphoid cells.

1989 • 145 citations

Signal transduction through small GTPases—A tale of two GAPs

1992 • 137 citations

SH1 Domain Autophosphorylation of P210 BCR/ABL Is Required for Transformation but Not Growth Factor Independence

1993 • 116 citations

Differences in oncogenic potency but not target cell specificity distinguish the two forms of the BCR/ABL oncogene.

1991 • 89 citations

Tyrosine phosphorylation of rasGAP and associated proteins in chronic myelogenous leukemia cell lines

1992 • 88 citations

SH1 domain autophosphorylation of P210 BCR/ABL is required for transformation but not growth factor independence.

1993 • 77 citations

High affinity DNA-binding Myc analogs: Recognition by an α helix

1993 • 75 citations

Tyrosine phosphorylation of rasGAP and associated proteins in chronic myelogenous leukemia cell lines

1992 • 64 citations

c-abl has a sequence-specific enhancer binding activity

1992 • 58 citations

The bcr-abl gene in chronic myelogenous leukaemia.

1992 • 49 citations