Phorbol 12,13-dibutyrate binding to intact human platelets. The role of cytosolic free Ca2+

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C

1984 • 2,728 citations

Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase

1986 • 2,445 citations

Turnover of Inositol Phospholipids and Signal Transduction

1984 • 1,629 citations

Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.

1980 • 1,317 citations

Phorbol diester receptor copurifies with protein kinase C.

1983 • 1,185 citations

Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.

1986 • 1,150 citations

Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters.

1983 • 890 citations

Inhibitory action of chlorpromazine, dibucaine, and other phospholipid-interacting drugs on calcium-activated, phospholipid-dependent protein kinase.

1980 • 464 citations

A model for intracellular translocation of protein kinase C involving synergism between Ca2+ and phorbol esters

1985 • 446 citations

Competitive inhibition by diacylglycerol of specific phorbol ester binding.

1984 • 306 citations

Mass changes in myoinositol trisphosphate in human platelets stimulated by thrombin. Inhibitory effects of phorbol ester.

1985 • 292 citations

Specific high affinity cell membrane receptors for biologically active phorbol and ingenol esters

1980 • 274 citations

Interaction of protein kinase C with membranes is regulated by Ca2+, phorbol esters, and ATP.

1985 • 274 citations

1,2-Diacylglycerol and phorbol ester inhibit agonist-induced formation of inositol phosphates in human platelets: possible implications for negative feedback regulation of inositol phospholipid hydrolysis.

1985 • 222 citations

Mechanism of action of the phorbol ester tumor promoters: Specific receptors for lipophilic ligands

1984 • 209 citations

Guanosine 5'-O-(thiotriphosphate)-dependent inositol trisphosphate formation in membranes is inhibited by phorbol ester and protein kinase C.

1987 • 203 citations

Role of intracellular calcium mobilization in the regulation of protein kinase C-mediated membrane processes

1985 • 201 citations

Specificity of the Fatty Acyl Moieties of Diacylglycerol for the Activation of Calcium-Activated, Phospholipid-Dependent Protein Kinase1

1982 • 182 citations

Protein kinase C heterogeneity in GH4C1 rat pituitary cells. Characterization of a Ca2(+)-independent phorbol ester receptor.

1990 • 126 citations

Inhibition of Protein Kinase C by Staurosporine Promotes Elevated Accumulations of Inositol Trisphosphates and Tetrakisphosphate in Human Platelets Exposed to Thrombin

1989 • 113 citations

Stimulation of Ca²⁺ efflux from fura‐2‐loaded platelets activated by thrombin or phorbol myristate acetate

1987 • 96 citations

Release of superoxide and change in morphology by neutrophils in response to phorbol esters: antagonism by inhibitors of calcium-binding proteins.

1985 • 83 citations

Receptor-mediated Modulation of Human Monocyte, Neutrophil, Lymphocyte, and Platelet Function by Phorbol Diesters

1982 • 80 citations

The protein kinase inhibitor staurosporine, like phorbol esters, induces the association of protein kinase C with membranes

1988 • 77 citations

Kinetics and subcellular localization of specific [3H]phorbol 12, 13-dibutyrate binding by mouse brain.

1981 • 77 citations

Ca2+ mobilization primes protein kinase C in human platelets. Ca2+ and phorbol esters stimulate platelet aggregation and secretion synergistically through protein kinase C.

1988 • 75 citations

Agonist-evoked alkaline shift in the cytosolic pH set point for activation of Na+/H+ antiport in human platelets. The role of cytosolic Ca2+ and protein kinase C.

1990 • 68 citations

Staurosporine inhibits protein kinase C and prevents phorbol ester-mediated leukotriene D4 receptor desensitization in RBL-1 cells.

1988 • 64 citations

Effects of staurosporine on protein kinase C and amylase secretion from pancreatic acini

1989 • 34 citations

Different developmental functions for calmodulin in dictyostelium: Trifluoperazine and R24571 both inhibit cell and pronuclear fusion but enhance gamete formation*1

1988 • 34 citations

Calcium mobilization and Na⁺/H⁺ antiport activation by endothelin in human skin fibroblasts

1989 • 23 citations

Phorbol ester receptors in bovine luteal cells: relationship to protein kinase C

1990 • 16 citations