Induced fit in initial selection and proofreading of aminoacyl-tRNA on the ribosome

Enzyme structure and mechanism

1977 • 2,935 citations

Enzyme structure and mechanism

1978 • 2,897 citations

Kinetic Proofreading: A New Mechanism for Reducing Errors in Biosynthetic Processes Requiring High Specificity

1974 • 1,532 citations

Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 Å resolution

1998 • 1,164 citations

Trna: Structure, Biosynthesis, and Function

1995 • 896 citations

Structure of the A Site of Escherichia coli 16 S Ribosomal RNA Complexed with an Aminoglycoside Antibiotic

1996 • 782 citations

Kinetic amplification of enzyme discrimination

1975 • 742 citations

Crystal structures of open and closed forms of binary and ternary complexes of the large fragment of Thermus aquaticus DNA polymerase I: structural basis for nucleotide incorporation

1998 • 682 citations

The role of guanosine 5′-triphosphate in polypeptide chain elongation

1978 • 559 citations

CONFORMATIONAL COUPLING IN DNA POLYMERASE FIDELITY

1993 • 558 citations

Mechanism of Inhibition of HIV-1 Reverse Transcriptase by Nonnucleoside Inhibitors

1995 • 523 citations

Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal

1998 • 520 citations

Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors

1995 • 435 citations

Complete kinetic mechanism of elongation factor Tu-dependent binding of aminoacyl-tRNA to the A site of the E.coli ribosome

1998 • 380 citations

Visualization of elongation factor Tu on the Escherichia coli ribosome

1997 • 353 citations

Multiple RNA Polymerase Conformations and GreA: Control of the Fidelity of Transcription

1993 • 292 citations

Paromomycin binding induces a local conformational change in the A-site of 16 s rRNA

1998 • 269 citations

A base pair between tRNA and 23S rRNA in the peptidyl transferase centre of the ribosome

1995 • 238 citations

Helix unwinding in the effector region of elongation factor EF-Tu–GDP

1996 • 216 citations

Hyper-accurate ribosomes inhibit growth.

1984 • 211 citations

Ribosomal Discrimination of tRNAs

1971 • 188 citations

An α to β conformational switch in EF-Tu

1996 • 183 citations

EFTu provides an internal kinetic standard for translational accuracy

1988 • 176 citations

Human immunodeficiency virus reverse transcriptase substrate-induced conformational changes and the mechanism of inhibition by nonnucleoside inhibitors.

1995 • 172 citations

Initial Binding of the Elongation Factor Tu·GTP·Aminoacyl-tRNA Complex Preceding Codon Recognition on the Ribosome

1996 • 162 citations

The role of induced fit and conformational changes of enzymes in specificity and catalysis

1988 • 155 citations

Codon-dependent conformational change of elongation factor Tu preceding GTP hydrolysis on the ribosome.

1995 • 146 citations

Transient Conformational States of Aminoacyl-tRNA during Ribosome Binding Catalyzed by Elongation Factor Tu

1994 • 146 citations

Kinetic properties of Escherichia coli ribosomes with altered forms of S12

1992 • 131 citations

The Involvement of Two Distinct Regions of 23 S Ribosomal RNA in tRNA Selection

1995 • 121 citations

Thermodynamic constraints on kinetic proofreading in biosynthetic pathways

1980 • 111 citations

Reexamination of induced fit as a determinant of substrate specificity in enzymic reactions

1995 • 79 citations

GROWTH-OPTIMIZING ACCURACY OF GENE EXPRESSION

1987 • 78 citations

Effects of nucleotide- and aurodox-induced changes in elongation factor Tu conformation upon its interactions with aminoacyl transfer RNA. A fluorescence study

1990 • 70 citations

Accuracy of protein biosynthesis. A kinetic study of the reaction of poly(U)-programmed ribosomes with a leucyl-tRNA2-elongation factor Tu-GTP complex.

1982 • 66 citations

Mutations in the peptidyl transferase region ofE.coli23S rRNA affecting translational accuracy

1994 • 58 citations

The 530 loop of 16S rRNA: a signal to EF-Tu?

1994 • 55 citations

The G222D mutation in elongation factor Tu inhibits the codon-induced conformational changes leading to GTPase activation on the ribosome.

1996 • 44 citations

tRNA on the Ribosome: a Waggle Theory

2014 • 43 citations

The rate of cleavage of GTP on the binding of Phe-tRNA.elongation factor Tu.GTP to poly(U)-programmed ribosomes of Escherichia coli.

1985 • 40 citations

Conformational Coupling in DNA Polymerase Fidelity

1993 • 23 citations

Growth-Optimizing Accuracy Of Gene Expression

1987 • 6 citations