Identification, Characterization, and Comparison of the Calmodulin-binding Domains of the Endothelial and Inducible Nitric Oxide Synthases

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

1990 • 3,304 citations

Nitric oxide synthases: Roles, tolls, and controls

1994 • 2,945 citations

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

1991 • 2,371 citations

Cloning and Characterization of Inducible Nitric Oxide Synthase from Mouse Macrophages

1992 • 1,914 citations

Solution structure of a calmodulin-target peptide complex by multidimensional NMR

1992 • 1,258 citations

Target Enzyme Recognition by Calmodulin: 2.4 Å Structure of a Calmodulin-Peptide Complex

1992 • 1,031 citations

Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform.

1992 • 1,004 citations

Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line.

1992 • 877 citations

Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.

1993 • 845 citations

How calmodulin binds its targets: sequence independent recognition of amphiphilic α-helices

1990 • 839 citations

Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein.

1991 • 812 citations

Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase.

1992 • 748 citations

Calmodulin is a subunit of nitric oxide synthase from macrophages.

1992 • 640 citations

Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase.

1992 • 616 citations

Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme.

1992 • 616 citations

Cloned human brain nitric oxide synthase is highly expressed in skeletal muscle

1993 • 552 citations

Mammalian Nitric Oxide Synthases

1992 • 514 citations

Molecular cloning and characterization of human endothelial nitric oxide synthase

1992 • 494 citations

Molecular cloning and expression of a cDNA encoding endothelial cell nitric oxide synthase.

1992 • 477 citations

The Nitric Oxide Synthase Family of Proteins

1994 • 465 citations

The interaction of calmodulin with amphiphilic peptides.

1985 • 239 citations

FAD and GSH participate in macrophage synthesis of nitric oxide

1990 • 182 citations

The γ-Subunit of Skeletal Muscle Phosphorylase Kinase Contains Two Noncontiguous Domains That Act in Concert to Bind Calmodulin

1989 • 172 citations

Transforming growth factor-beta 1, but not dexamethasone, down-regulates nitric-oxide synthase mRNA after its induction by interleukin-1 beta in rat smooth muscle cells.

1994 • 169 citations

The calmodulin binding domain of nitric oxide synthase and adenylyl cyclase

1993 • 165 citations

[37] Recognition and characterization of calmodulin-binding sequences in peptides and proteins

1987 • 143 citations

Interaction of Bordetella pertussis adenylate cyclase with calmodulin. Identification of two separated calmodulin-binding domains.

1988 • 141 citations

Characterization of the calmodulin-binding and catalytic domains in skeletal muscle myosin light chain kinase.

1985 • 108 citations

Characterization of the calmodulin-binding domain of rat cerebellar nitric oxide synthase.

1994 • 107 citations

Role of the Enzyme Calmodulin-binding Domain in Membrane Association and Phospholipid Inhibition of Endothelial Nitric Oxide Synthase

1995 • 96 citations

A calmodulin-binding peptide of caldesmon.

1991 • 72 citations

Identification of amino acids essential for calmodulin binding and activation of smooth muscle myosin light chain kinase.

1992 • 66 citations

Identification of inducible calmodulin-dependent nitric oxide synthase in the liver of rats.

1992 • 53 citations

Predicted calmodulin‐binding sequence in the γ subunit of phosphorylase b kinase

1987 • 43 citations

Enzymatic characterisation of recombinant murine inducible nitric oxide synthase

1995 • 19 citations