What are antibiotics? Archaic functions for modern activities

Bacterial evolution

1987 • 2,303 citations

Meteorites and the early solar system

1989 • 1,957 citations

DNA TOPOISOMERASES

1985 • 1,524 citations

Interaction of antibiotics with functional sites in 16S ribosomal RNA

1987 • 1,143 citations

Before enzymes and templates: theory of surface metabolism

1988 • 1,016 citations

Structure, Function, and Genetics of Ribosomes

1986 • 852 citations

Role of a phenazine antibiotic from Pseudomonas fluorescens in biological control of Gaeumannomyces graminis var. tritici

1988 • 724 citations

RNA evolution and the origins of life

1989 • 629 citations

INHIBITION BY PUROMYCIN OF AMINO ACID INCORPORATION INTO PROTEIN

1959 • 561 citations

The organic component in dust from comet Halley as measured by the PUMA mass spectrometer on board Vega 1

1987 • 534 citations

Modern metabolism as a palimpsest of the RNA world.

1989 • 472 citations

Pre-biotic organic matter from comets and asteroids

1989 • 403 citations

Genetics and Molecular Biology of Industrial Microorganisms

1989 • 319 citations

RNA-Protein Interactions in 30 S Ribosomal Subunits: Folding and Function of 16 S rRNA

1989 • 292 citations

Nucleoside antibiotics: Structure, biological activity, and biosynthesis.

1988 • 292 citations

Speculations on the early course of evolution.

1986 • 284 citations

Antibiotic proteins of human polymorphonuclear leukocytes.

1989 • 273 citations

A Specific Amino Acid Binding Site Composed of RNA

1988 • 203 citations

Thiostrepton-induced gene expression in Streptomyces lividans

1989 • 199 citations

Which Organic Compounds Could Have Occurred on the Prebiotic Earth?

1987 • 175 citations

Site of action of a ribosomal RNA methylase conferring resistance to thiostrepton.

1982 • 147 citations

Mutations in ribosomal proteins S4 and S12 influence the higher order structure of 16 S ribosomal RNA

1989 • 121 citations

Function of Peptide Antibiotics in Sporulation

1972 • 98 citations

Amino-acid synthesis in carbonaceous meteorites by aqueous alteration of polycyclic aromatic hydrocarbons

1990 • 97 citations

What's in a Name?—Microbial Secondary Metabolism

1989 • 96 citations

Insensitivity of archaebacterial ribosomes to protein synthesis inhibitors. Evolutionary implications.

1985 • 85 citations

On the nature of antibiotic binding sites in ribosomes

1987 • 63 citations

Transposon Tn916 mutagenesis in Bacillus anthracis

1988 • 62 citations

Susceptibility of Giardia lamblia to aminoglycoside protein synthesis inhibitors: correlation with rRNA structure

1989 • 60 citations

New Applications of Microbial Products

1983 • 58 citations

Characterization of the Conjugation System Associated with the Staphylococcus aureus Plasmid pJE1

1988 • 50 citations

Antibiotic resistance by modification: Many resistance genes could be derived from cellular control genes in actinomycetes - A hypothesis.

1988 • 49 citations

What are secondary metabolites?

1979 • 39 citations

Inhibition of bacterial DNA synthesis by edeine. Effect on Escherichia coli mutants lacking DNA polymerase I

1972 • 24 citations

Role and regulation mechanism of kanamycin acetyltransferase in kanamycin biosynthesis.

1975 • 20 citations

Direct activation of cGMP-dependent channels of retinal rods by the cGMP phosphodiesterase.

1989 • 14 citations

Novobiocin and Coumermycin A1

1979 • 9 citations

New tool for studying interactions of components of ribonucleic acid polymerase: rifampin-dependent mutants

1979 • 8 citations

Lincomycin increases the half-life of beta-lactamase mRNA

1989 • 6 citations

Iron Scavenging in the Pathogenesis of Escherichia coli

1989 • 2 citations