Interaction of antibiotics with functional sites in 16S ribosomal RNA

The Molecular Basis of Antibiotic Action

1981 • 1,237 citations

Direct chemical method for sequencing RNA.

1979 • 940 citations

STRUCTURE OF RIBOSOMAL RNA

1984 • 793 citations

Comparative Anatomy of 16-S-like Ribosomal RNA

1985 • 689 citations

Rapid chemical probing of conformation in 16 S ribosomal RNA and 30 S ribosomal subunits using primer extension

1986 • 535 citations

Identification and Functional Characterization of the Protein controlled by the Streptomycin-resistant Locus in E. coli

1969 • 461 citations

Transfer RNA shields specific nucleotides in 16S ribosomal RNA from attack by chemical probes

1986 • 425 citations

Detailed analysis of the higher-order structure of 16S-like ribosomal ribonucleic acids.

1983 • 351 citations

Inhibitors of protein biosynthesis

2006 • 335 citations

Antibiotic resistance mutations in 16S and 23S ribosomal RNA genes ofEscherichia coli

1984 • 241 citations

Specific Inactivation of 16S Ribosomal RNA Induced by Colicin E3 In Vivo

1971 • 238 citations

Inhibitors of Protein Biosynthesis

1979 • 233 citations

Covalent crosslinking of tRNA1Val to 16S RNA at the ribosomal P site: identification of crosslinked residues.

1982 • 203 citations

The nucleotide sequence of the 17S ribosomal RNA gene of Tetrahymena thermophila and the identification of point mutations resulting in resistance to the antibiotics paromomycin and hygromycin.

1985 • 198 citations

Identification of the paromomycin-resistance mutation in the 15 S rRNA gene of yeast mitochondria.

1982 • 188 citations

Effect of Colicin E3 upon the 30S Ribosomal Subunit of Escherichia coli

1971 • 169 citations

Inhibition of aminoacyl-sRNA binding to ribosomes by tetracycline

1965 • 166 citations

A further study of misreading of codons induced by streptomycin and neomycin using ribopolynucleotides containing two nucleotides in alternating sequence as templates

1966 • 145 citations

Ribosomal Protein Conferring Sensitivity to the Antibiotic Spectinomycin in Escherichia coli

1969 • 138 citations

Altered Ribosomal Protein in Streptomycin-Dependent Escherichia coli

1969 • 135 citations

Localization of the binding site for protein S4 on 16 S ribosomal RNA by chemical and enzymatic probing and primer extension

1986 • 127 citations

Dual Interference of Hygromycin B with Ribosomal Translocation and with Aminoacyl-tRNA Recognition

1978 • 115 citations

Inhibition by kasugamycin of initiation complex formation on 30S ribosomes

1971 • 114 citations

E. coli ribosomes with a C912 to U base change in the 16S rRNA are streptomycin resistant.

1986 • 104 citations

Streptomycin preferentially perturbs ribosomal proofreading

1984 • 103 citations

Ram ribosomes are defective proofreaders

1983 • 88 citations

Streptomycin-resistance ofEuglena gracilischloroplasts: identification of a point mutation in the 16S rRNA gene in an invariant position

1985 • 86 citations

INHIBITION OF PROTEIN SYNTHESIS BY CHLORTETRACYCLINE IN THE E. COLI IN VITRO SYSTEM

1965 • 83 citations

Restriction, de-restriction and mistranslation in missense suppression. Ribosomal discrimination of transfer RNA's

1972 • 74 citations

Binding of specific sRNA to 30S ribosomal subunits: effect of 50S ribosomal subunits.

1966 • 72 citations

Effect of Mg2+ concentration, polyamines, streptomycin, and mutations in ribosomal proteins on the accuracy of the two-step selection of aminoacyl-tRNAs in protein biosynthesis.

1981 • 70 citations

The tertiary folding of Escherichia coli 16S RNA, as studied by in situ intra-RNA cross-linking of 30S ribosomal subunits with bis-(2-chloroethyI)-methylamine

1986 • 54 citations

Transfer RNA selection at the ribosomal A and P sites

1979 • 50 citations

Paromomycin and Dihydrostreptomycin Binding to Escherichia coli Ribosomes

1976 • 45 citations

Bacterial‐Protein Synthesis

1973 • 45 citations

Effect of edeine on aminoacyl-tRNA binding to ribosomes and its relationship to ribosomal binding sites

1970 • 43 citations

Identification of the site of crosslinking in 16S rRNA of an aromatic azide photoaffinity probe attached to the 5'-anticodon base of A site-bound tRNA

1985 • 35 citations

Comparative Analysis of the Effect of Aminoglycosides on Bacterial Protein Synthesis in vitro

1979 • 35 citations

Selective Inhibition of Initiating Ribosomes by Spectinomycin

1974 • 33 citations

Functional interaction of neomycin B and related antibiotics with 30S and 50S ribosomal subunits

1979 • 25 citations

Crosslinking of the anticodon of P and A site-bound tRNAs to the ribosome via aromatic azides of variable length: involvement of 16S rRNA at the A site

1985 • 23 citations

Effect of streptomycin on the stoichiometry of GTP hydrolysis in a poly(U)‐dependent cell‐free translation system

1985 • 14 citations