Evolution of differential substrate specificities in Mu class glutathione transferases probed by DNA shuffling 1 1Edited by R. Huber
Data up to Jan 2025
Total Citations Per Year
Abstract
References (45)
Glutathione S-Transferases
1974 • 17,321 citations
The Glut athione S-Transferase Supergene Family: Regulation of GST and the Contribution of the lsoenzymes to Cancer Chemoprotection and Drug Resistance Part I
1995 • 3,492 citations
Why genes in pieces?
1978 • 2,256 citations
Rapid evolution of a protein in vitro by DNA shuffling
1994 • 1,901 citations
Glutathione Transferases—Structure and Catalytic Activit
1988 • 1,751 citations
DNA shuffling by random fragmentation and reassembly: in vitro recombination for molecular evolution.
1994 • 1,274 citations
Improved Green Fluorescent Protein by Molecular Evolution Using DNA Shuffling
1996 • 1,212 citations
Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties.
1985 • 1,081 citations
The Isoenzymes of Glutathione Transferase
1985 • 960 citations
DNA shuffling of a family of genes from diverse species accelerates directed evolution
1998 • 821 citations
Theta, a new class of glutathione transferases purified from rat and man
1991 • 743 citations
Zeta, a novel class of glutathione transferases in a range of species from plants to humans
1997 • 498 citations
Detoxication of base propenals and other alpha,beta-unsaturated aldehyde products of radical reactions and lipid peroxidationby human glutathione transferases.
1994 • 412 citations
The three-dimensional structure of a glutathione S-transferase from the Mu gene class. Structural analysis of the binary complex of isoenzyme 3-3 and glutathione at 2.2-.ANG. resolution
1992 • 372 citations
Glutathione transferases catalyse the detoxication of oxidized metabolites (o-quinones) of catecholamines and may serve as an antioxidant system preventing degenerative cellular processes
1997 • 338 citations
Glutathione S-transferase class Kappa: characterization by the cloning of rat mitochondrial GST and identification of a human homologue
1996 • 298 citations
Directed evolution of a fucosidase from a galactosidase by DNA shuffling and screening
1997 • 275 citations
Characterization of the Human Class Mu Glutathione S-Transferase Gene Cluster and the GSTM1Deletion
1998 • 201 citations
Directed evolution of an aspartate aminotransferase with new substrate specificities
1998 • 196 citations
On the mechanism of the Mn3+-induced neurotoxicity of dopamine: Prevention of quinone-derived oxygen toxicity by DT diaphorase and superoxide dismutase
1989 • 187 citations
Molecular evolution of an arsenate detoxification pathway by DNA shuffling
1997 • 182 citations
Steps towards life: a perspective on evolution
1993 • 170 citations
Glutathione S‐transferases: Amino acid sequence comparison, classification and phylogenetic relationship
1992 • 167 citations
Advances in Drug Metabolism in Man
1995 • 167 citations
Characterization of rat spleen prostaglandin H <scp>d</scp>-isomerase as a sigma-class GSH transferase
1995 • 149 citations
Crystal Structure of Human Class mu Glutathione Transferase GSTM2-2
1994 • 132 citations
Human Class Mu Glutathione Transferases, in Particular Isoenzyme M2-2, Catalyze Detoxication of the Dopamine Metabolite Aminochrome
1997 • 127 citations
The human liver glutathione S-transferase gene superfamily: expression and chromosome mapping of an Hbsubunit cDNA
1988 • 109 citations
Construction and evolution of antibody–phage libraries by DMA shuffling
1996 • 97 citations
Heterologous expression of the allelic variant mu-class glutathione transferases μ and ψ
1991 • 96 citations
Cloning, expression, and characterization of a class-mu glutathione transferase from human muscle, the product of the GST4 locus.
1991 • 76 citations
Functional and nonfunctional mutations distinguished by random recombination of homologous genes
1997 • 72 citations
Superoxide Dismutase and Catalase Enhance Autoxidation during One-Electron Reduction of Aminochrome by NADPH-Cytochrome P-450 Reductase
1995 • 71 citations
Gene expression of rat glutathione S-transferases. Evidence for gene conversion in the evolution of the Yb multigene family.
1988 • 71 citations
A Comparison of the Enzymatic and Physicochemical Properties of Human Glutathione Transferase M4-4 and Three Other Human Mu Class Enzymes
1994 • 66 citations
Random recombination of antibody single chain Fv sequences after fragmentation with DNasel in the presence of Mn2+
1995 • 56 citations
Design of two chimaeric human-rat class alpha glutathione transferases for probing the contribution of C-terminal segments of protein structure to the catalytic properties
1992 • 56 citations
Modular mutagenesis of exons 1, 2, and 8 of a glutathione S-transferase from the Mu class. Mechanistic and structural consequences for chimeras of isoenzyme 3-3
1992 • 55 citations
Glutathione S-Transferases: Structure, Function and Clinical Implications
2007 • 46 citations
Structure of human glutathione S-transferase class Mu genes
1991 • 41 citations
The High Activity of Rat Glutathione Transferase 8−8 with Alkene Substrates Is Dependent on a Glycine Residue in the Active Site
1995 • 32 citations
Optimized Heterologous Expression of the Polymorphic Human Glutathione Transferase M1-1 Based on Silent Mutations in the Corresponding cDNA
1996 • 22 citations
Evidence for cytosolic glutathione transferase-mediated denitrosation of nitrosocimetidine and 1-methyl-2-nitro-1-nitrosoguanidine
1987 • 20 citations
Evolution of glutathione transferases and related enzymes for the protection of cells against electrophiles
1996 • 20 citations
Denitrosation of 1,3-dimethyl-2-cyano-1-nitrosoguanidine in rat primary hepatocyte cultures
1997 • 6 citations