The synaptosome: An isolated, working, neuronal compartment

EVIDENCE FOR THE EXISTENCE OF MONOAMINE-CONTAINING NEURONS IN THE CENTRAL NERVOUS SYSTEM. I. DEMONSTRATION OF MONOAMINES IN THE CELL BODIES OF BRAIN STEM NEURONS.

1964 • 5,110 citations

Thomas, Springfield, Illinois

1965 • 2,935 citations

The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation.

1962 • 2,522 citations

EVIDENCE FOR THE EXISTENCE OF MONOAMINE NEURONS IN THE CENTRAL NERVOUS SYSTEM. II. EXPERIMENTALLY INDUCED CHANGES IN THE INTRANEURONAL AMINE LEVELS OF BULBOSPINAL NEURON SYSTEMS.

1965 • 1,004 citations

Experiments on the mechanism of nerve growth

1948 • 829 citations

CHOLINERGIC AND NON‐CHOLINERGIC NERVE ENDINGS IN RAT BRAIN–I

1962 • 784 citations

The Neurosciences: Second Study Program

1971 • 671 citations

The isolation and characterization of acetylcholine-containing particles from brain

1959 • 570 citations

SUBCELLULAR DISTRIBUTION OF THE ENZYMES OF THE GLUTAMIC ACID, GLUTAMINE AND γ‐AMINOBUTYRIC ACID CYCLES IN RAT BRAIN*

1965 • 539 citations

The application of subcellular fractionation techniques to the study of brain function

1965 • 466 citations

THE "VESICLE IN A BASKET"

1969 • 445 citations

The pharmacology of amino acids related to gamma-aminobutyric acid.

1965 • 333 citations

The Interaction of Drugs and Subcellular Components in Animal Cells

1969 • 331 citations

Isolation of plasma membranes from rat brain

1971 • 304 citations

Unique High Affinity Uptake Systems for Glycine, Glutamic and Aspartic Acids in Central Nervous Tissue of the Rat

1971 • 295 citations

Autoradiography of some suspected neurotransmitter substances: GABA glycine, glutamic acid, histamine, dopamine, and pl-dopa

1971 • 275 citations

Ultrastructure and Cytochemistry of the Synaptic Region

1967 • 271 citations

Glutamate and γ-Aminobutyric Acid in Brain

1970 • 269 citations

The distribution of glutamate decarboxylase and aspartate transaminase in subcellular fractions of rat and guinea-pig brain

1968 • 249 citations

Autoradiographic identification of cerebral and cerebellar cortical neurons accumulating labeled gamma-aminobutyric acid (3H-GABA)

1972 • 244 citations

Amino Acid Transmitters

1970 • 235 citations

Biochemical studies of synapses in vitro. I. Protein synthesis

1968 • 224 citations

METABOLISM OF BEDS OF MAMMALIAN CORTICAL SYNAPTOSOMES: RESPONSE TO DEPOLARIZING INFLUENCES

1972 • 215 citations

The localization of adenosine triphosphatases in morphologically characterized subcellular fractions of guinea-pig brain

1965 • 208 citations

LACTATE DEHYDROGENASE AS A CYTOPLASMIC MARKER IN BRAIN

1963 • 202 citations

The release of γ‐aminobutyric acid during inhibition in the cat visual cortex

1971 • 201 citations

Rate of release of amino acids from the cerebral cortex in the cat as affected by brainstem and thalamic stimulation

1969 • 194 citations

Phosphorylation of Endogenous Protein of Rat Brain by Cyclic Adenosine 3′,5′-Monophosphate-dependent Protein Kinase

1971 • 192 citations

Distribution of sodium-plus-potassium-stimulated adenosine-triphosphatase activity in isolated nerve-ending particles

1965 • 189 citations

The ‘compartmentation’ of choline acetyltransferase within the synaptosome

1967 • 182 citations

RESPIRATION IN VITRO OF SYNAPTOSOMES FROM MAMMALIAN CEREBRAL CORTEX

1969 • 181 citations

Subcellular distribution of taurine and cysteinesulphinate decarboxylase in developing rat brain

1971 • 179 citations

The uptake of [14C]choline into synaptosomes in vitro

1968 • 177 citations

Role of sodium, potassium, quabain and reserpine in uptake, storage and metabolism of biogenic amines in synaptosomes

1968 • 159 citations

The distribution of free amino acids in subcellular fractions of guinea-pig brain

1966 • 155 citations

SYNTHESIS AND RELEASE OF [¹⁴C]ACETYLCH0LINE IN SYNAPTOSOMES

1971 • 148 citations

SODIUM-POTASSIUM-ACTIVATED ATPase AND POTASSIUM-ACTIVATED p-NITROPHENYLPHOSPHATASE: A COMPARISON OF THEIR SUBCELLULAR LOCALIZATIONS IN RAT BRAIN

1965 • 144 citations

METABOLISM OF GLUCOSE AND GLUTAMATE BY SYNAPTOSOMES FROM MAMMALIAN CEREBRAL CORTEX

1969 • 142 citations

DEPOLARIZING STIMULI AND THE RELEASE OF PHYSIOLOGICALLY ACTIVE AMINO ACIDS FROM SUSPENSIONS OF MAMMALIAN SYNAPTOSOMES

1973 • 141 citations

The osmotically sensitive potassium and sodium compartments of synaptosomes

1967 • 137 citations

The morphology of fractions of rat forebrain synaptosomes separated on continuous sucrose density gradients

1968 • 131 citations

Metabolic response of synaptosomes to electrical stimulation: Release of amino acids

1970 • 131 citations

Light and electron microscopic autoradiography on spinal cord slices after incubation with labeled glycine

1971 • 127 citations

INCORPORATION OF ¹⁴C‐LABELLED LEUCINE INTO SYNAPTOSOMES FROM RAT CEREBRAL CORTEX IN VITRO

1967 • 127 citations

On synaptic vesicles, complex vesicles and dense projections

1970 • 126 citations

The subcellular localization of 5-hydroxytryptamine in guinea pig brain

1963 • 123 citations

ASPECTS OF ACETYLCHOLINE METABOLISM IN THE ELECTRIC ORGAN OF TORPEDO MARMORATA

1971 • 122 citations

A Unique Synaptosomal Fraction, Which Accumulates Glutamic and Aspartic Acids, in Brain Tissue

1971 • 117 citations

PATTERNS OF AMINO ACID RELEASE FROM NERVE-ENDINGS ISOLATED FROM SPINAL CORD AND MEDULLA

1973 • 114 citations

STUDIES ON SODIUM–POTASSIUM ADENOSINE TRIPHOSPHATASE OF THE NERVE ENDINGS AND APPEARANCE OF ELECTRICAL ACTIVITY IN DEVELOPING RAT BRAIN

1967 • 113 citations

Ultrastructure and cholinergic binding capacity of junctional complexes isolated from rat brain

1967 • 113 citations

Quantitative studies of norepinephrine uptake by synaptosomes

1968 • 110 citations

Localization of different steps in noradrenaline synthesis to different fractions of a bovine splenic nerve homogenate

1967 • 110 citations

The biosynthesis of 5-hydroxytryptamine in brain

1967 • 106 citations

SUBCELLULAR DISTRIBUTION OF ENZYMES OF GLUTAMATE METABOLISM IN RAT BRAIN

1966 • 106 citations

Efflux of amino acid neurotransmitters from rat spinal cord slices. II. Factors influencing the electrically induced efflux of [14Cglycine and3H-GABA

1971 • 105 citations

Exchangeability of radioactive acetylcholine with the bound acetylcholine of synaptosomes and synaptic vesicles

1968 • 101 citations

THE BRAIN BARRIER SYSTEM–III

1962 • 101 citations

Autoradiographic localisation of tritiated glycine at ‘flat-vesicle’ synapses in spinal cord

1971 • 101 citations

Intraretinal distribution of GABA content and GAD activity

1972 • 96 citations

Synaptosomes: Different Populations storing Catecholamines and Gamma-aminobutyric Acid in Homogenates of Rat Brain

1968 • 94 citations

SYNTHESIS OF RADIOACTIVE ACETYLCHOLINE FROM [³H]CHOLINE AND ITS RELEASE FROM CEREBRAL CORTEX SLICES IN VITRO

1971 • 92 citations

Cyclic 3′,5′-Nucleotide Phosphodiesterase: Localization and Latent Activity in Rat Brain

1967 • 91 citations

SUBCELLULAR LOCALIZATION OF N‐ACETYL‐ASPARTYL‐GLUTAMATE, N‐ACETYL‐GLUTAMATE AND GLUTATHIONE IN BRAIN

1969 • 88 citations

Subcellular distribution of glutamic decarboxylase and gamma- aminobutyric alpha-ketoglutaric transaminase

1963 • 78 citations

Mechanism of biogenic amine transport. II. Relationship between sodium and the mechanism of ouabain blockade of the accumulation of serotonin and norepinephrine by synaptosomes.

1969 • 77 citations

The stimulus‐induced release of acetylcholine from synaptosome beds and its calcium dependence

1972 • 73 citations

LOCALIZATION OF γ‐AMINOBUTYRIC‐α‐OXOGLUTARIC ACID TRANSAMINASE IN MOUSE BRAIN*

1968 • 72 citations

Biochemical studies of synapses in vitro. II. Potassium transport

1969 • 72 citations

5‐HYDROXYTRYPTOPHAN DECARBOXYLASE ACTIVITY IN NERVE ENDINGS OF THE RAT BRAIN*

1964 • 69 citations

AMINO ACIDS AS PUTATIVE TRANSMITTERS: FAILURE TO BIND TO SYNAPTIC VESICLES OF GUINEA PIG CEREBRAL CORTEX¹

1972 • 69 citations

ON THE TURNOVER OF ACETYLCHOLINE IN NERVE ENDINGS OF MOUSE BRAIN IN VIVO

1970 • 69 citations

Bidirectional movements of mitochondria along axons of an isolated nerve segment

1968 • 63 citations

Formation of Catechol Compounds from Phenylalanine and Tyrosine with Isolated Nerve Endings

1972 • 60 citations

Separation of synaptosomes storing catecholamines and gamma-aminobutyric acid in rat corpus striatum

1970 • 60 citations

HEXOSE MONOPHOSPHATE PATHWAY IN SYNAPSES¹

1970 • 59 citations

STUDIES ON SODIUM TRANSPORT IN RAT BRAIN NERVE‐ENDING PARTICLES

1968 • 59 citations

Adenosinetriphosphatase activity in synaptic vesicles of rat brain

1965 • 58 citations

Synthesis and release of (14C) acetylcholine in synaptosomes

1970 • 58 citations

ISOLATION OF [³H]ACETYLCHOLINE POOLS BY SUBCELLULAR FRACTIONATION OF CEREBRAL CORTEX SLICES INCUBATED WITH [³H]CHOLINE

1971 • 58 citations

DISTRIBUTION OF TYROSINE HYDROXYLASE ACTIVITY IN ADULT AND DEVELOPING BRAIN

1967 • 57 citations

The uptake of amino acids by particulate fractions from brain

1969 • 54 citations

Subcellular localization of tyrosine hydroxylase in beef caudate nucleus

1965 • 54 citations

Subcellular distribution of sodium-potassium adenosine triphosphatase, acetylcholine and acetylcholinesterase in developing rat brain

1970 • 52 citations

OBSERVATIONS ON THE SUBCELLULAR DISTRIBUTION OF CHOLINE ACETYLTRANSFERASE IN THE BRAIN TISSUE OF MAMMALS AND COMPARISONS OF ACETYLCHOLINE SYNTHESIS FROM ACETATE AND CITRATE IN HOMOGENATES AND NERVE‐ENDING FRACTIONS

1967 • 50 citations

THE SUBCELLULAR LOCALIZATION OF DOPAMINE AND ACETYLCHOLINE IN THE DOG CAUDATE NUCLEUS

1963 • 50 citations

Noradrenaline formation from dopamine in isolated subcellular particles from bovine splenic nerve

1967 • 49 citations

Adenosine Triphosphate Dependent Calcium Binding of Microsomes and Nerve Endings

1966 • 47 citations

UPTAKE OF CALCIUM BY SUBCELLULAR FRACTIONS ISOLATED FROM OUABAIN‐TREATED CEREBRAL TISSUES

1969 • 46 citations

An autoradiographic study of uptake of exogenous glycine by vertebrate spinal cord splicesin vitro

1972 • 45 citations

A LIGHT‐SCATTERING TECHNIQUE FOR THE STUDY OF THE PERMEABILITY OF RAT BRAIN SYNAPTOSOMES IN VITRO

1970 • 45 citations

ASSOCIATION OF TYROSINE HYDROXYLASE WITH SYNAPTIC VESICLES IN BOVINE CAUDATE NUCLEUS¹

1969 • 45 citations

Protein synthesis in isolated rat brain mitochondria and nerve endings

1971 • 40 citations

Calcium accumulation by isolated nerve ending particles from brain. I. The site of energy-dependent accumulation

1969 • 40 citations

Uptake of L‐histidine, L‐proline, L‐tyrosine and L‐ornithine by brain, intestinal mucosa, testis, kidney, spleen, liver, heart muscle, skeletal muscle and erythrocytes of the rat in vitro

1962 • 39 citations

CHARACTERISTICS REQUIRED IN ELECTRICAL PULSES OF RECTANGULAR TIME‐VOLTAGE RELATIONSHIPS FOR METABOLIC CHANGE AND ION MOVEMENTS IN MAMMALIAN CEREBRAL TISSUES

1963 • 39 citations

Chemical and Metabolic Characteristics of Synaptic Complexes from Brain Isolated by Zonal Centrifugation in a Cesium Chloride Gradient

1971 • 36 citations

Zonal centrifuge profiles of rat brain homogenates: Instability in sucrose, stability in iso-osmotic Ficoll-sucrose

1971 • 36 citations

The Properties of ATPase of Synaptic Vesicle Fraction

1967 • 36 citations

Relative Contribution of Carbon Dioxide Fixation and Acetyl-CoA Pathways in Two Nervous Tissues

1967 • 35 citations

The subcellular localization of brain-stem norepinephrine and 5-hydroxytryptamine in stressed rats

1964 • 35 citations

The storage of norepinephrine and some of its derivatives in brain synaptosomes

1965 • 35 citations

Biological Sciences: Release of Amino-acids and Neurosecretory Substances after Stimulation of Nerve-endings (Synaptosomes) isolated from the Hypothalamus

1972 • 33 citations

ELECTRON MICROSCOPE HISTOCHEMICAL EVIDENCE FOR A PARTIAL OR TOTAL BLOCK OF THE TRICARBOXYLIC ACID CYCLE IN THE MITOCHONDRIA OF PRESYNAPTIC AXON TERMINALS

1971 • 32 citations

Observations on the morphology of mammalian synaptosomes following their incubation and electrical stimulation

1971 • 31 citations

Further studies on synaptic junctions

1972 • 30 citations

A morphological and biochemical study of subcellular fractions of the guinea pig spinal cord

1971 • 30 citations

Studies on the Subcellular Localization of Corticotrophin Releasing Factor (CRF) and Vasopressin in the Median Eminence of the Rat¹

1970 • 29 citations

Changes in acetylcholinesterase, acid phosphatase and beta glucuronidase proximal to a nerve crush

1970 • 29 citations

BIDIRECTIONAL SHIFT OF MITOCHONDRIA IN AXONS AFTER INJURY

1969 • 27 citations

Energy metabolism and synaptosomal protein synthesis

1969 • 27 citations

Studies on [32P]orthophosphate incorporation into nucleotides, phospholipids and phosphoproteins of isolated nerve endings from developing rat brain

1968 • 26 citations

Localization of adenosine 3′,5′‐monophosphate‐dependent protein kinase in brain

1971 • 25 citations

Protein synthesis by brain-cortex mitochondria. Characterization of a 55S mitochondrial ribosome as the functional unit in protein synthesis by cortex mitochondria and its distinction from a contaminant cytoplasmic protein-synthesizing system

1971 • 23 citations

THE DISTRIBUTION OF CATION‐STIMULATED ADENOSINE TRIPHOSPHATASE IN SUB‐CELLULAR FRACTIONS FROM BOVINE CEREBRAL CORTEX

1966 • 23 citations

Calcium accumulation by isolated nerve ending particles from brain. II. Factors influencing calcium movements

1969 • 23 citations

Studies of the respiration of synaptosomes

1971 • 22 citations

Further studies on synaptic junctions

1972 • 22 citations

Phospholipid metabolism of isolated nerve endings

1970 • 20 citations

ELECTRON MICROSCOPIC DEMONSTRATION OF ENERGY PRODUCTION AND COUPLED RESPIRATION OF IN SITU MITOCHONDRIA

1970 • 16 citations

SUBCELLULAR DISTRIBUTION OF POTASSIUM, SODIUM, MAGNESIUM, CALCIUM AND CHLORIDE IN CEREBRAL CORTEX¹

1972 • 16 citations

Carbohydrate Metabolism

1969 • 14 citations

Biochemistry of brain tissue

1940 • 13 citations

Intracellular distribution of brain noradrenalin and De Robertis' non-cholinergic nerve endings

1963 • 13 citations

Isolation of a fraction from rat cerebellum enriched in nerve terminals of one single type (mossy-fibre terminals)

1972 • 8 citations

The physiological role of taurine

1971 • 7 citations

Chromatography of methyl ethers of d-glucosamine

1971 • 7 citations

Association of organic and inorganic anions with synaptosomes from mouse brain

1971 • 7 citations

Can the brain be improved?

1969 • 7 citations

THE DISTRIBUTION OF SYNAPTOSOMAL OXIDATIVE ENZYMES AFTER EXPOSURE TO DEOXYCHOLATE^1,2

1970 • 5 citations

METABOLISM OF NERVE-ENDING PARTICLES

1969 • 4 citations

Release of corticotrophin-releasing factor (CRF) following the electrical stimulation of nerve-endings isolated from the sheep hypothalamus.

1972 • 2 citations