In vivo expansion of gene‐modified hematopoietic cells by a novel selective amplifier gene utilizing the erythropoietin receptor as a molecular switch

Gene Therapy of Human Severe Combined Immunodeficiency (SCID)-X1 Disease

2000 • 2,632 citations

Production of high-titer helper-free retroviruses by transient transfection.

1993 • 2,280 citations

Structural design and molecular evolution of a cytokine receptor superfamily.

1990 • 2,104 citations

Correction of ADA-SCID by Stem Cell Gene Therapy Combined with Nonmyeloablative Conditioning

2002 • 1,136 citations

Versatile retroviral vectors for potential use in gene therapy.

1994 • 690 citations

Erythropoietin Receptor Activation by a Ligand-Induced Conformation Change

1999 • 624 citations

Crystallographic Evidence for Preformed Dimers of Erythropoietin Receptor Before Ligand Activation

1999 • 597 citations

Colocalization of retrovirus and target cells on specific fibronectin fragments increases genetic transduction of mammalian cells

1996 • 565 citations

Retrovirally marked CD34-enriched peripheral blood and bone marrow cells contribute to long-term engraftment after autologous transplantation

1995 • 496 citations

Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin

1998 • 389 citations

Role of c-mpl in Early Hematopoiesis

1998 • 362 citations

Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and Shc phosphorylation.

1995 • 183 citations

Ability of Early Acting Cytokines to Directly Promote Survival and Suppress Apoptosis of Human Primitive CD34+CD38− Bone Marrow Cells With Multilineage Potential at the Single-Cell Level: Key Role of Thrombopoietin

1997 • 169 citations

A proliferation switch for genetically modified cells

1997 • 108 citations

In vivo selection using a cell-growth switch

2000 • 97 citations

Pharmacologically regulated in vivo selection in a large animal

2002 • 75 citations

Safety and efficacy of erythropoietin in children with chronic renal failure

1999 • 66 citations

In vivo transfection of testicular germ cells and transgenesis by using the mitochondrially localized jellyfish fluorescent protein gene

2000 • 59 citations

Novel Erythropoiesis Stimulating Protein

2000 • 57 citations

Absence of polycythemia in a child with a unique erythropoietin receptor mutation in a family with autosomal dominant primary polycythemia.

1998 • 57 citations

Expansion of genetically modified primary human hemopoietic cells using chemical inducers of dimerization

2000 • 46 citations

Receptor specificity in the self-renewal and differentiation of primary multipotential hemopoietic cells

2001 • 44 citations

Receptor-based model accounts for phlebotomy-induced changes in erythropoietin pharmacokinetics

2001 • 38 citations

Development of a Novel Selective Amplifier Gene for Controllable Expansion of Transduced Hematopoietic Cells

1997 • 37 citations

In vivo selective expansion of gene-modified hematopoietic cells in a nonhuman primate model

2002 • 36 citations

Proliferation of multipotent hematopoietic cells controlled by a truncated erythropoietin receptor transgene.

1996 • 29 citations

Identification of Functional Domains of the Human Thrombopoietin Receptor Required for Growth and Differentiation of Megakaryocytic Cells

1997 • 28 citations

A selective amplifier gene for tamoxifen-inducible expansion of hematopoietic cells

1999 • 28 citations

The use of epoetin alfa in chemotherapy patients: A consistent profile of efficacy and safety

2002 • 23 citations

Development of a modified selective amplifier gene for hematopoietic stem cell gene therapy

1999 • 20 citations

In vivo expansion of transduced murine hematopoietic cells with a selective amplifier gene

2002 • 15 citations

Mpl and the hematopoietic stem cell

2002 • 7 citations

Evaluation of Phlebotomy-Induced Erythropoietin Production in the Dog.

1993 • 6 citations

New selective amplifier genes containing c-Mpl for hematopoietic cell expansion

2003 • 5 citations