Modafinil and cocaine: a double-blind, placebo-controlled drug interaction study

SAS System for Mixed Models

1996 • 10,609 citations

DISEASES OF THE NERVOUS SYSTEM

1918 • 1,308 citations

Abstinence Symptomatology and Psychiatric Diagnosis in Cocaine Abusers

1986 • 1,134 citations

Neurobiology of addiction

1996 • 1,082 citations

Neuroscience of Addiction

1998 • 1,030 citations

Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects

1997 • 843 citations

Cardiovascular Complications of Cocaine Use

2001 • 788 citations

New concepts in cocaine addiction: The dopamine depletion hypothesis

1985 • 608 citations

Postcocaine anhedonia. An animal model of cocaine withdrawal.

1991 • 505 citations

Achieving cocaine abstinence with a behavioral approach

1993 • 499 citations

Classical Conditioning in Drug‐Dependent Humansa

1992 • 473 citations

Cocaine-induced cocaine craving

1989 • 381 citations

The Prefrontal Cortex Regulates the Basal Release of Dopamine in the Limbic Striatum: An Effect Mediated by Ventral Tegmental Area

1996 • 365 citations

Psychotherapy and Pharmacotherapy for Ambulatory Cocaine Abusers

1994 • 349 citations

Book Review: Reward Signaling by Dopamine Neurons

2001 • 347 citations

Modafinil Binds to the Dopamine Uptake Carrier Site with Low Affinity

1994 • 317 citations

Cocaine dependence: a disease of the brain’s reward centers

2001 • 314 citations

Potential brain neuronal targets for amphetamine-, methylphenidate-, and modafinil-induced wakefulness, evidenced by c- fos immunocytochemistry in the cat

1996 • 305 citations

Evaluation of the Abuse Liability of Modafinil and Other Drugs for Excessive Daytime Sleepiness Associated with Narcolepsy

2000 • 296 citations

Changes in Mood, Craving, and Sleep During Short-term Abstinence Reported by Male Cocaine Addicts

1990 • 284 citations

Cocaine-Induced Psychosis and Sudden Death in Recreational Cocaine Users

1985 • 278 citations

A Comparative Trial of Psychotherapies for Ambulatory Cocaine Abusers: Relapse Prevention and Interpersonal Psychotherapy

1991 • 273 citations

Basal extracellular dopamine is decreased in the rat nucleus accumbens during abstinence from chronic cocaine

1991 • 265 citations

Reliability and validity of the cocaine selective severity assessment

1998 • 252 citations

An evaluation of the abuse potential of modafinil using methylphenidate as a reference

2000 • 238 citations

Central α1-adrenergic stimulation in relation to the behaviour stimulating effect of modafinil; studies with experimental animals

1990 • 221 citations

Modafinil Augmentation of Antidepressant Treatment in Depression

2000 • 212 citations

Role of catecholamines in the modafinil and amphetamine induced wakefulness, a comparative pharmacological study in the cat

1992 • 207 citations

Cocaine and amphetamine preferentially stimulate glutamate release in the limbic system: Studies on the involvement of dopamine

1997 • 203 citations

Modafinil, d‐amphetamine and placebo during 64 hours of sustained mental work. I. Effects on mood, fatigue, cognitive performance and body temperature

1995 • 192 citations

Health-Related Quality of Life Effects of Modafinil for Treatment of Narcolepsy

1999 • 188 citations

Repeated Cocaine Administration Alters Extracellular Glutamate in the Ventral Tegmental Area

1998 • 186 citations

Clinical phenomenology and neurobiology of cocaine abstinence: a prospective inpatient study

1991 • 179 citations

Effect of modafinil on heat production and regulation of body temperatures in cold-exposed humans.

1994 • 173 citations

A Double‐Blind, Placebo‐Controlled, Ascending‐Dose Evaluation of the Pharmacokinetics and Tolerability of Modafinil Tablets in Healthy Male Volunteers

1999 • 158 citations

Evaluation of the cocaine-like discriminative stimulus effects and reinforcing effects of modafinil

1996 • 157 citations

GABA_A Receptor Blockade in the Anterior Ventral Tegmental Area Increases Extracellular Levels of Dopamine in the Nucleus Accumbens of Rats

1997 • 154 citations

Modafinil: An antinarcoleptic drug with a different neurochemical profile to d-amphetamine and dopamine uptake blockers

1997 • 139 citations

Intracranial hemorrhage associated with cocaine abuse

1996 • 128 citations

Cocaine withdrawal symptoms and initial urine toxicology results predict treatment attrition in outpatient cocaine dependence treatment.

2001 • 127 citations

Cocaine abuse: neurovascular complications.

1989 • 127 citations

Outcomes for cocaine abusers after once-a-week psychosocial therapy

1991 • 126 citations

Apparent synaptic dopamine deficiency induced by withdrawal from chronic cocaine treatment

1991 • 126 citations

Effectiveness and Costs of Inpatient versus Day Hospital Cocaine Rehabilitation

1994 • 122 citations

Acute and protracted cocaine abstinence in an outpatient population: A prospective study of mood, sleep and withdrawal symptoms

2000 • 121 citations

The effects of modafinil on striatal, pallidal and nigral GABA and glutamate release in the conscious rat: evidence for a preferential inhibition of striato-pallidal GABA transmission

1998 • 119 citations

Striatal Dopaminergic Abnormalities in Human Cocaine Users

1999 • 116 citations

Effects of Modafinil in Children With Attention-Deficit/Hyperactivity Disorder: An Open-Label Study

2001 • 114 citations

The neurobiology of addiction: an overview.

1997 • 108 citations

The vigilance promoting drug modafinil decreases GABA release in the medial preoptic area and in the posterior hypothalamus of the awake rat: possible involvement of the serotonergic 5-HT3 receptor

1996 • 106 citations

Cocaine-induced wide complex dysrhythmia

1997 • 102 citations

Prediction of attrition from day hospital treatment in lower socioeconomic cocaine-dependent men

1996 • 101 citations

Central nervous system infarction related to cocaine abuse.

1991 • 100 citations

Chronic cocaine alters limbic extracellular dopamine. Neurochemical basis for addiction

1992 • 99 citations

Non-amphetaminic mechanism of stimulant locomotor effect of modafinil in mice

1995 • 99 citations

ネコ脳のアンフェタミン,メチルフェニデート,モダフィニルの覚醒作用における標的ニューロンのc‐fos免疫組織化学による検索

1996 • 94 citations

Decreasing Striatal 6-FDOPA Uptake with Increasing Duration of Cocaine Withdrawal

1997 • 90 citations

Cocaine Abstinence Symptomatology and Treatment Attrition

1999 • 85 citations

Effect of modafinil on plasma melatonin, cortisol and growth hormone rhythms, rectal temperature and performance in healthy subjects during a 36 h sleep deprivation

1998 • 83 citations

Single‐Dose Pharmacokinetics of Modafinil and Methylphenidate Given Alone or in Combination in Healthy Male Volunteers

1998 • 81 citations

Effect of modafinil and amphetamine on the rat catecholaminergic neuron activity

1991 • 75 citations

Use of modafinil in the treatment of narcolepsy: A long term follow-up study

1996 • 68 citations

Modafinil and cortical γ-aminobutyric acid outflow. Modulation by 5-hydroxytryptamine neurotoxins

1995 • 68 citations

Cardiac complications of cocaine abuse

1995 • 67 citations

Modafinil: the unique properties of a new stimulant.

1991 • 65 citations

Comparison of the Single‐Dose Pharmacokinetics and Tolerability of Modafinil and Dextroamphetamine Administered Alone or in Combination in Healthy Male Volunteers

1998 • 57 citations

ADDICTION RESEARCH CENTER INVENTORY (ARCI)

1965 • 55 citations

Toxic Mechanisms of the Heart: A Review*

1990 • 54 citations

Subjective reports of withdrawal among cocaine users: recommendations for DSM-IV

1993 • 51 citations

Cocaine Abuse: Repolarization Abnormalities and Ventricular Arrhythmias

2000 • 47 citations

Reduced glutamate immunolabeling in the nucleus accumbens following extended withdrawal from self-administered cocaine

1998 • 42 citations

Fatal Malignant Hyperthermia Associated with Recreational Cocaine and Ethanol Abuse

1986 • 37 citations

Effects of a vigilance-enhancing drug, modafinil, on rat brain metabolism: 2D COSY 1H-NMR study

1995 • 35 citations

Effects of the vigilance promoting drug modafinil on the synthesis of GABA and glutamate in slices of rat hypothalamus

1999 • 32 citations

Differential effects of the new central adrenergic agonist modafinil and d-amphetamine on sleep and early morning behaviour in elderlies.

1989 • 32 citations

Cocaine Abuse: Repolarization Abnormalities and Ventricular Arrhythmias

2000 • 32 citations

Cocaine dependence: the challenge for pharmacotherapy

2002 • 27 citations

Diseases of the Nervous System.

1909 • 23 citations

Stroke

1993 • 22 citations

Nonamphetamine awakening agent modafinil induces feeding changes in the rat

1993 • 19 citations

Cardiovascular responses to cocaine placebo in humans: A preliminary report

1989 • 18 citations

Illicit cocaine use patterns in intravenous-naive cocaine users following investigational intravenous cocaine administration

2000 • 18 citations

A Quasi-Experimental Comparison of the Effectiveness of 6- versus 12-Hour per Week Outpatient Treatments for Cocaine Dependence

1996 • 13 citations

Novel French antidepressants not available in the United States.

1995 • 6 citations