Populations and genetic polymorphisms.

Mutation in blood coagulation factor V associated with resistance to activated protein C

1994 • 3,871 citations

A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis

1996 • 3,682 citations

The History and Geography of Human Genes

2018 • 3,334 citations

Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences.

1997 • 995 citations

Human Cytochrome P450 Enzymes

1995 • 731 citations

Characterization of the common genetic defect in humans deficient in debrisoquine metabolism

1988 • 717 citations

Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine.

1993 • 652 citations

Nomenclature for human CYP2D6 alleles

1996 • 406 citations

Nomenclature for N-acetyltransferases

1995 • 378 citations

Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution

1997 • 378 citations

Frequent distribution of ultrarapid metabolizers of debrisoquine in an ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles.

1996 • 373 citations

Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis.

1995 • 310 citations

Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism.

1991 • 273 citations

Human acetyltransferase polymorphisms

1997 • 267 citations

Characterisation and PCR‐based detection of a CYP2A6 gene deletion found at a high frequency in a Chinese population

1999 • 207 citations

Frequent occurrence of CYP2D6 gene duplication in Saudi Arabians

1997 • 202 citations

Codeine increases pain thresholds to copper vapor laser stimuli in extensive but not poor metabolizers of sparteine

1990 • 196 citations

Prevalence of CYP2D6 gene duplication and its repercussion on the oxidative phenotype in a white population*

1995 • 187 citations

The Acetylator Genes and Drug Response

1987 • 183 citations

Interactions of amphetamine analogs with human liver CYP2D6

1997 • 173 citations

A Genetic Polymorphism in the Regulatory Sequences of HumanCYP2E1:Association with Increased Chlorzoxazone Hydroxylation in the Presence of Obesity and Ethanol Intake

1998 • 159 citations

Molecular cloning and nucleotide sequence of cDNA for human glucose-6-phosphate dehydrogenase variant A(-).

1988 • 151 citations

Alcohol dehydrogenase-2*3 allele protects against alcohol-related birth defects among African Americans.

1997 • 149 citations

Genetically deficient CYP2D6 metabolism provides protection against oral opiate dependence

1997 • 133 citations

Genetical and Geographic Studies on Isoniazid Inactivation

1961 • 132 citations

Quick Onset of Severe Abdominal Pain After Codeine in an Ultrarapid Metabolizer of Debrisoquine

1997 • 124 citations

Characterization of a Human GlutathioneS-Transferase μ Cluster Containing a DuplicatedGSTM1Gene that Causes Ultrarapid Enzyme Activity

1997 • 118 citations

The relationship between low Km aldehyde dehydrogenase phenotype and drinking behavior in Japanese.

1992 • 106 citations

An additional defective allele, CYP2C19*5, contributes to the S-mephenytoin poor metabolizer phenotype in Caucasians

1998 • 100 citations

Paroxetine potentiates the central nervous system side effects of perphenazine: Contribution of cytochrome P4502D6 inhibition in vivo*

1997 • 84 citations

Genotypes of alcohol dehydrogenase and aldehyde dehydrogenase loci in Japanese alcohol flushers and nonflushers

1989 • 81 citations

Dissociation of co-regulatory control of debrisoquin/phenformin and sparteine oxidation in Ghanaians

1985 • 63 citations

Human Biology: An Introduction to Human Evolution, Variation and Growth

1965 • 56 citations

RACIAL DIFFERENCES AS ILLUSTRATED BY THE MYDRIATIC ACTION OF COCAINE, EUPHTHALMINE, AND EPHEDRINE

1929 • 50 citations

ON DICHLORETHYLSULPHIDE (MUSTARD GAS) II. VARIATIONS IN SUSCEPTIBILITY OF THE SKIN TO DICHLORETHYLSULPHIDE

1918 • 47 citations

The Molecular Biology of G6PD Variants and Other Red Cell Enzyme Defects

1992 • 46 citations

Human acetylator polymorphism: estimate of allele frequency in Libya and details of global distribution.

1981 • 43 citations

Some Differences in Response to Atropine in White and Colored Races.

1921 • 17 citations

Genetic Polymorphism of Drug Metabolizing Enzymes. Implications for Toxicity of Drugs and Other Xenobiotics

1997 • 13 citations

[Genetic polymorphism of drug metabolizing enzymes].

1997 • 9 citations

EPHEDRINE

1927 • 7 citations