Interactions of amphetamine analogs with human liver CYP2D6

Polymorphic dextromethorphan metabolism: Co-segregation of oxidative O-demethylation with debrisoquin hydroxylation

1985 • 386 citations

The genetic polymorphism of debrisoquine/sparteine metabolism — Clinical aspects

1990 • 367 citations

Clinical significance of the sparteine/debrisoquine oxidation polymorphism

1989 • 292 citations

Inhibition by fluoxetine of cytochrome P450 2D6 activity

1993 • 259 citations

The metabolic fate of amphetamine in man and other species

1970 • 247 citations

The demethylenation of methylenedioxymethamphetamine (“ecstasy”) by debrisoquine hydroxylase (CYP2D6)

1994 • 237 citations

Biotransformation of caffeine, paraxanthine, theophylline, and theobromine by polycyclic aromatic hydrocarbon-inducible cytochrome(s) P-450 in human liver microsomes.

1987 • 203 citations

Metabolism of methylenedioxymethamphetamine: formation of dihydroxymethamphetamine and a quinone identified as its glutathione adduct.

1990 • 195 citations

Body temperature : regulation, drug effects, and therapeutic implications

1979 • 176 citations

Metabolic polymorphisms

1993 • 168 citations

“It's the genes, stupid” Molecular bases and clinical consequences of genetic cytochrome P450 2D6 polymorphism

1995 • 162 citations

Use of quinidine inhibition to define the role of the sparteine/debrisoquine cytochrome P450 in metoprolol oxidation by human liver microsomes.

1988 • 161 citations

Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22

1988 • 157 citations

Absence of hepatic cytochrome P450bufI causes genetically deficient debrisoquine oxidation in man

1988 • 152 citations

Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: possible association with the poor metabolizer phenotype

1991 • 147 citations

Molecular genetics of the debrisoquin-sparteine polymorphism

1991 • 132 citations

MPTP, the neurotoxin inducing parkinson's disease, is a potent competitive inhibitor of human and rat cytochrome P450 isozymes (P450bufI, P450db1) catalyzing debrisoquine 4-hydroxylation

1987 • 130 citations

Neuronal cytochrome P450IID1 (debrisoquine/sparteine-type): potent inhibition of activity by (-)-cocaine and nucleotide sequence identity to human hepatic P450 gene CYP2D6.

1991 • 125 citations

Dextromethorphan: Enhancing its systemic availability by way of low-dose quinidine-mediated inhibition of cytochrome P4502D6

1992 • 88 citations

Interindividual and interspecies variation in the metabolism of the hallucinogen 4-methoxyamphetamine

1979 • 80 citations

Effect of quinidine on the dextromethorphan O‐demethylase activity of microsomal fractions from human liver.

1989 • 72 citations

Enzymic and chemical demethylenation of (methylenedioxy)amphetamine and (methylenedioxy)methamphetamine by rat brain microsomes

1992 • 67 citations

Quinidine: potent inhibition of sparteine and debrisoquine oxidation in vivo.

1986 • 67 citations

PMA deaths in Ontario.

1974 • 61 citations

Synthesis and neurotoxicological evaluation of putative metabolites of the serotonergic neurotoxin 2-(methylamino)-1-[3,4-(methylenedioxy)phenyl]propane [(methylenedioxy)methamphetamine]

1992 • 56 citations

Participation of cytochrome P450-2B and -2D isozymes in the demethylenation of methylenedioxymethamphetamine enantiomers by rats.

1994 • 51 citations

Catalytic activities of human debrisoquine 4-hydroxylase cytochrome P450 (CYP2D6) expressed in yeast

1992 • 43 citations

Stimulus Properties of Hallucinogenic Phenalkylamines and Related Designer Drugs: Formulation of Structure-Activity Relationships

1989 • 41 citations

Directional lipophilic character in a series of psychotomimetic phenethylamine derivatives

1977 • 39 citations

Manganese-mediated increase in the rat brain mitochondrial cytochrome P-450 and drug metabolism activity: susceptibility of the striatum.

1989 • 37 citations

Evidence in humans for variant allozymes of the nondeficient sparteine/debrisoquine monooxygenase (P45OIID 1) in vitro.

1989 • 28 citations

Introduction

1986 • 26 citations

Spectral and inhibitory interactions of (±)−3, 4-methylenedioxyamphetamine (MDA) and (±)−3, 4-methylenedioxymethampetamine (MDMA) with rat hepatic microsomes

1986 • 17 citations

Stereoselective accumulation of hydroxylated metabolites of amphetamine in rat striatum and hypothalamus

1986 • 15 citations

Sparteine Metabolism Capacity in Human Liver: Structural Variants of Human P450IID6 as Assessed by Immunochemistry

1990 • 13 citations

Determination of Amphetamine, Norephedrine, and Their Phenolic Metabolites in Rat Brain by Gas Chromatography

1984 • 7 citations

Self-injection in baboons of amphetamines and related designer drugs.

1989 • 7 citations

Formation of α-Methyldopamine (‘Catecholamphetamine’) from p-Hydroxyamphetamine by Rat Brain Microsomes

1979 • 5 citations

Self-Injection in Baboons of Amphetamines and Related Designer Drugs

1989 • 2 citations