Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000).

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.

1989 • 1,752 citations

Localization of the glial fibrillary acidic protein in astrocytes by immunofluorescence

1972 • 1,456 citations

Molecular profile of reactive astrocytes—Implications for their role in neurologic disease

1993 • 1,436 citations

An acidic protein isolated from fibrous astrocytes

1971 • 1,192 citations

Leukocyte Infiltration, Neuronal Degeneration, and Neurite Outgrowth after Ablation of Scar-Forming, Reactive Astrocytes in Adult Transgenic Mice

1999 • 1,071 citations

GFAP and Astrogliosis

1994 • 810 citations

Glial fibrillary acidic protein (GFAP): the major protein of glial intermediate filaments in differentiated astrocytes

1985 • 714 citations

GFAP Is Necessary for the Integrity of CNS White Matter Architecture and Long-Term Maintenance of Myelination

1996 • 521 citations

Intermediate filaments in nervous tissues

1978 • 502 citations

Adrenoleukodystrophy

1975 • 459 citations

Deficient Cerebellar Long-Term Depression, Impaired Eyeblink Conditioning, and Normal Motor Coordination in GFAP Mutant Mice

1996 • 392 citations

GFAP mRNA increases with age in rat and human brain

1993 • 391 citations

Abnormal Reaction to Central Nervous System Injury in Mice Lacking Glial Fibrillary Acidic Protein and Vimentin

1999 • 386 citations

EFFECTS OF MITOTIC SPINDLE INHIBITORS ON NEUROTUBULES AND NEUROFILAMENTS IN ANTERIOR HORN CELLS

1968 • 379 citations

Targeted deletion in astrocyte intermediate filament (Gfap) alters neuronal physiology.

1996 • 347 citations

The development of the pathologic changes of Alzheimer's disease and senile dementia in patients with Down's syndrome.

1973 • 340 citations

Diffuse senile plaques occur commonly in the cerebellum in Alzheimer's disease.

1989 • 336 citations

Mice lacking glial fibrillary acidic protein display astrocytes devoid of intermediate filaments but develop and reproduce normally.

1995 • 334 citations

The pathological association between down syndrome and Alzheimer disease

1988 • 334 citations

Patterns of gliosis in alzheimer's disease and aging cerebrum

1989 • 318 citations

Contribution of immunohistochemistry to diagnostic problems of human cerebral tumors.

1978 • 318 citations

Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice

1998 • 306 citations

Mice devoid of the glial fibrillary acidic protein develop normally and are susceptible to scrapie prions

1995 • 258 citations

Suppression by antisense mRNA demonstrates a requirement for the glial fibrillary acidic protein in the formation of stable astrocytic processes in response to neurons.

1991 • 241 citations

The role of glial fibrillary acidic protein in the diagnosis of central nervous system tumors

1978 • 240 citations

Fatal encephalopathy with astrocyte inclusions in GFAP transgenic mice.

1998 • 237 citations

A4 Protein in Alzheimer's Disease: Primary and Secondary Cellular Events in Extracellular Amyloid Deposition

1989 • 236 citations

Immunogenic properties of the glial fibrillary acidic protein

1976 • 235 citations

Glial Fibrillary Acidic Protein: Regulation by Hormones, Cytokines, and Growth Factors

1994 • 230 citations

Glial Fibrillary Acidic Protein–Apolipoprotein E (apoE) Transgenic Mice: Astrocyte-Specific Expression and Differing Biological Effects of Astrocyte-Secreted apoE3 and apoE4 Lipoproteins

1998 • 213 citations

Preparation of antisera to neurofilament protein from chicken brain and human sciatic nerve

1977 • 213 citations

Specificity of the glial fibrillary acidic protein for astroglia.

1977 • 213 citations

Astrocyte-specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie

1997 • 212 citations

Immunological study of the glial fibrillary acidic protein

1972 • 191 citations

Neuropathology of Organic Brain Syndromes Associated with Aging

1972 • 182 citations

Glial fibrillary acidic protein and Alzheimer‐type senile dementia

1980 • 176 citations

Biochemistry of the filaments of brain.

1976 • 176 citations

Astrogliosis in culture: I. The model and the effect of antisense oligonucleotides on glial fibrillary acidic protein synthesis

1993 • 161 citations

Fibrous Astrocytes in Senile Dementia of the Alzheimer Type

1981 • 159 citations

Alpha B-crystallin and 27-kd heat shock protein are regulated by stress conditions in the central nervous system and accumulate in Rosenthal fibers.

1993 • 158 citations

Glial Fibrillary Acidic Protein: Dynamic Property and Regulation by Phosphorylation

1994 • 156 citations

Synthesis and Turnover of Cytoskeletal Proteins in Cultured Astrocytes

1984 • 152 citations

Glial fibrillary acidic protein in cryogenic lesions of the rat brain

1981 • 151 citations

Structure and Transcriptional Regulation of the GFAP Gene

1994 • 146 citations

Fungal Aneurysms of Intracranial Vessels

1976 • 144 citations

Disrupted glial fibrillary acidic protein network in astrocytes from vimentin knockout mice.

1996 • 140 citations

Proteolysis of Vimentin and Desmin by the Ca²⁺-Activated Proteinase Specific for These Intermediate Filament Proteins

1983 • 139 citations

Isolation and characterization of glial filaments from human brain.

1978 • 138 citations

Blood-brain and blood-spinal cord barrier permeability during the course of experimental allergic encephalomyelitis in the rat

1984 • 133 citations

Immunocytochemical staining for glial fibrillary acidic protein and the metabolism of cytoskeletal proteins in experimental allergic encephalomyelitis

1983 • 130 citations

Experimental autoimmune encephalomyelitis in mice lacking glial fibrillary acidic protein is characterized by a more severe clinical course and an infiltrative central nervous system lesion.

1998 • 129 citations

Conditional Ablation of Cerebellar Astrocytes in Postnatal Transgenic Mice

1996 • 124 citations

Lamina-specific arrangement of astrocytic gliosis and senile plaques in Alzheimer's disease visual cortex

1988 • 118 citations

Mice lacking GFAP are hypersensitive to traumatic cerebrospinal injury

1998 • 113 citations

Identification of Glial Fibrillary Acidic Protein by the Immunoperoxidase Method in Human Brain Tumors

1977 • 108 citations

Overexpression of TGF-β1 in the Central Nervous System of Transgenic Mice Results in Hydrocephalus

1995 • 107 citations

Grafts of EGF-responsive neural stem cells derived from GFAP-hNGF transgenic mice: Trophic and tropic effects in a rodent model of Huntington's disease

1997 • 105 citations

Degradation of glial fibrillary acidic protein protein by a calcium dependent proteinase: an electroblot study

1983 • 104 citations

Effects of antisense glial fibrillary acidic protein complementary DNA on the growth, invasion, and adhesion of human astrocytoma cells.

1994 • 102 citations

GFAP-Deficient Astrocytes Are Capable of Stellationin VitroWhen Cocultured with Neurons and Exhibit a Reduced Amount of Intermediate Filaments and an Increased Cell Saturation Density

1998 • 101 citations

Temporal Expression of Mouse Glial Fibrillary Acidic Protein mRNA Studied by a Rapid In Situ Hybridization Procedure

1985 • 101 citations

Glial fibrillary acidic protein from bovin and rat brain Degradation in tissues and homogenates

1976 • 95 citations

Intermediate Filaments from Bovine, Rat, and Human CNS: Mapping Analysis of the Major Proteins

1980 • 91 citations

Glial Fibrillary Acidic Protein Increases in the Spinal Cord of Lewis Rats with Acute Experimental Autoimmune Encephalomyelitis

1988 • 90 citations

Fibrous astrocytes in Alzheimer's disease and senile dementia of Alzheimer's type

1983 • 87 citations

Co‐expression of nestin and vimentin intermediate filaments in invasive human astrocytoma cells

1999 • 84 citations

Transgenic mice and cytokine actions in the brain: bridging the gap between structural and functional neuropathology1Published on the World Wide Web on 21 October 1997.1

1998 • 84 citations

Neurons induce GFAP gene promoter of cultured astrocytes from transgenic mice

1999 • 83 citations

Glial overexpression of NGF enhances neuropathic pain and adrenergic sprouting into DRG following chronic sciatic constriction in mice

1998 • 82 citations

Neuritic Outgrowth Associated with Astroglial Phenotypic Changes Induced by Antisense Glial Fibrillary Acidic Protein (GFAP) mRNA in Injured Neuron–Astrocyte Cocultures

1997 • 82 citations

GFAP Transgenic Mice

1996 • 79 citations

Altered taurine release following hypotonic stress in astrocytes from mice deficient for GFAP and vimentin

1998 • 79 citations

Axonal and Nonneuronal Cell Responses to Spinal Cord Injury in Mice Lacking Glial Fibrillary Acidic Protein

1997 • 74 citations

Modified Bielschowsky and Immunocytochemical Studies on Cerebellar Plaques in Alzheimer's Disease

1990 • 72 citations

Astrocyte hypertrophy in the Alzheimer's disease hippocampal formation

1991 • 72 citations

Calcium-mediated breakdown of glial filaments and neurofilaments in rat optic nerve and spinal cord

1981 • 72 citations

Immunohistochemistry of the Glial Fibrillary Acidic Protein: Basic and Applied Considerations

1994 • 71 citations

Dissociation of GFAP intermediate filaments in eae: Observations in the lumbar spinal cord

1989 • 71 citations

Brain Vascular Permeability to I¹²⁵Gamma Globulin and Leukocytes in Allergic Encephalomyelitis^*†

1967 • 66 citations

Structural features of the rat GFAP gene and identification of a novel alternative transcript

1999 • 64 citations

The protein composition of bovine myelin-free axons

1976 • 63 citations

Immunological Distinction between Neurofilament and Glial Fibrillary Acidic Proteins by Mouse Antisera and Their Immunohistological Characterization (Part 1 of 2)

1978 • 63 citations

Reexpression of glial fibrillary acidic protein rescues the ability of astrocytoma cells to form processes in response to neurons.

1994 • 62 citations

Acute-phase responses in transgenic mice with CNS overexpression of IL-1 receptor antagonist

1999 • 58 citations

Multiple Sclerosis. Pathology, Diagnosis and Management.

1983 • 58 citations

Astrocytes cultured from transgenic mice carrying the added human glial fibrillary acidic protein gene contain rosenthal fibers

1998 • 54 citations

Astrocyte-specific expression of tyrosine hydroxylase after intracerebral gene transfer induces behavioral recovery in experimental Parkinsonism

1998 • 54 citations

Scrapie in mice deficient in apolipoprotein E or glial fibrillary acidic protein

1996 • 54 citations

Localization of Metallothionein-I and -III Expression in the CNS of Transgenic Mice with Astrocyte-Targeted Expression of Interleukin 6

1998 • 53 citations

Glial Fibrillary Acidic Protein in the Cytoskeletal and Soluble Protein Fractions of the Developing Rat Brain

1987 • 52 citations

Astrocyte-targeted expression of IFN-alpha1 protects mice from acute ocular herpes simplex virus type 1 infection.

1998 • 51 citations

Study of Glial Fibrillary Acidic Protein in a Human Glioma Cell Line Grown in Culture and as a Solid Tumor

1983 • 51 citations

Astrogliosis in culture: III. Effect of recombinant retrovirus expressing antisense glial fibrillary acidic protein RNA

1994 • 48 citations

Antigenic profile of plaques and neurofibrillary tangles in the amygdala in Down's syndrome: a comparison with Alzheimer's disease

1990 • 46 citations

Inhibition of GFAP synthesis by antisense RNA in astrocytes

1991 • 45 citations

Neuronal and Glial Gene Expression in Neocortex of Downʼs Syndrome and Alzheimerʼs Disease

1993 • 43 citations

Intermediate filaments in astrocytes

1999 • 42 citations

Selective astrocytic transgene expression in vitro and in vivo from the GFAP promoter in a HSV RL1 null mutant vector – potential glioblastoma targeting

1998 • 41 citations

Microtubules and intermediate filaments.

1976 • 40 citations

Primary astrocytes retrovirally transduced with a tyrosine hydroxylase transgene driven by a glial-specific promoter elicit behavioral recovery in experimental Parkinsonism

2000 • 38 citations

Studies of human and bovine spinal nerve roots and the outgrowth of CNS tissues into the nerve root entry zone

1979 • 36 citations

Transfection and overexpression of metallothionein-I in neonatal rat primary astrocyte cultures and in astrocytoma cells increases their resistance to methylmercury-induced cytotoxicity

1999 • 36 citations

Cerebral amyloid angiopathy and astrocytic gliosis in Alzheimer's disease

1989 • 36 citations

Generation and Transplantation of EGF-Responsive Neural Stem Cells Derived from GFAP–hNGF Transgenic Mice

1997 • 35 citations

Human apolipoprotein E allele-specific brain expressing transgenic mice

1998 • 34 citations

Biochemical correlates of astrocytic proliferation in the mutant Staggerer mouse

1977 • 33 citations

Isolation from peripheral nerve of a protein similar to the glial fibrillary acidic protein

1976 • 33 citations

ON NEUROFILAMENT and NEUROTUBULE PROTEINS FROM HUMAN AUTOPSY TISSUE

1977 • 33 citations

Isolation and initial characterization of glial fibrillary acidic protein from chicken, turtle, frog and fish central nervous systems

1976 • 27 citations

Chapter 40: Astrocytic gliosis in the amygdala in Down's syndrome and Alzheimer's disease

1992 • 23 citations

Characterization of glial filament-cytoskeletal interactions in human astrocytomas: An immuno-ultrastructural analysis

1998 • 22 citations

A PRELIMINARY STUDY OF GLIOMA MORPHOLOGY USING THE PEROXIDASE-ANTI PEEOXIDASE IMMUNOHISTOLOGICAL METHOD FOR GLIAL FIBRILLARY ACIDIC PROTEIN

1976 • 21 citations

Cell‐type specific segregation of transcriptional expression of glial genes in the rat peripheral neurotumor RT4 cell lines

1993 • 20 citations

ON THE RELATIONSHIP OF BRAIN FILAMENTS TO MICROTUBULES¹

1974 • 20 citations

Cell-free synthesis of glial fibrillary acidic protein

1980 • 19 citations

Solubilization of neurofilaments from central nervous system myelinated nerve

1977 • 17 citations

Gene therapy in a rodent model of Parkinson's disease using differentiated C6 cells expressing a GFAP-tyrosine hydroxylase transgene

1999 • 16 citations

Alzheimer's disease: β-amyloid precursor protein expression in plaques varies among cytoarchitectonic areas of the medial temporal lobe

1991 • 13 citations

Neuronal fibrillar proteins and axoplasmic transport

1975 • 10 citations

Immunocytochemical distribution of S-100 protein in patients with Down's syndrome

1990 • 10 citations

Use of GFAP-lacZ transgenic mice to determine astrocyte fate in grafts of embryonic ventral midbrain.

1998 • 10 citations