Steady state concentrations of clomipramine and its major metabolite desmethylclomipramine in rat brain and serum after oral administration of clomipramine

Influence of dose and route of administration on the kinetics of fluoxetine and its metabolite norfluoxetine in the rat

1990 • 200 citations

Human brain fluoxetine concentrations

1993 • 197 citations

Persistence of Haloperidol in Human Brain Tissue

1999 • 136 citations

Clinical Pharmacokinetics of Clomipramine

1991 • 113 citations

Brain concentrations of tricyclic antidepressants: Single-dose kinetics and relationship to plasma concentrations in chronically dosed rats

1982 • 112 citations

The pharmacokinetics of diazepam and desmethyldiazepam in rat brain and plasma

1986 • 103 citations

Therapeutic Drug Monitoring

1995 • 93 citations

Clomipramine in Obsessive-Compulsive Disorder

1990 • 88 citations

Blood and brain concentrations of imipramine, clomipramine and their monomethylated metabolites after oral and intramuscular administration in rats

1977 • 78 citations

Inhibition of antidepressant demethylation and hydroxylation by fluvoxamine in depressed patients

1993 • 75 citations

Drug distribution between blood and brain as a determinant of antipsychotic drug effects

1992 • 73 citations

Combination treatment with clomipramine and fluvoxamine: drug monitoring, safety, and tolerability data.

1996 • 68 citations

Distribution of clozapine and desmethylclozapine between blood and brain in rats

1999 • 61 citations

Differences between antipsychotic drugs in persistence of brain levels and behavioral effects

1992 • 61 citations

Pharmacokinetics of chlorimipramine and its demethylated metabolite in blood and brain regions of rats treated acutely and chronically with chlorimipramine.

1983 • 51 citations

Therapeutic Drug Monitoring for the Treatment of Psychiatric Disorders

1995 • 45 citations

Automated determination of clomipramine and its major metabolites in human and rat serum by high-performance liquid chromatography with on-line column-switching

1998 • 32 citations

Comparison of the metabolism of the three antidepressants amitriptyline, imipramine, and chlorimipramine in vitro in rat liver microsomes

1986 • 21 citations

Rat Tissue Concentrations of Chlorimipramine, Chlorpromazine and their N-Demethylated Metabolites after a Single Oral Dose of the Parent Compounds

1995 • 21 citations

Tissue Distribution of Diazepam and Its Metabolite Desmethyldiazepam: A Human Autopsy Study

1985 • 20 citations

Prediction of Changes in the Clinical Pharmacokinetics of Basic Drugs on the Basis of Octanol-Water Partition Coefficients

1997 • 19 citations

Changes of serotonin and catecholamines are related to pharmacokinetic alterations of cloimpramine in rat brain

1991 • 18 citations

Serum levels of clomipramine and desmethylclomipramine and clinical improvement in panic disorder

1999 • 11 citations

A Pharmacokinetic Study of Clomipramine in Regions of the Brain

1986 • 10 citations

Distribution of clomipramine in various brain regions of rats under steady-state serum concentrations

1988 • 7 citations