Persistence of Haloperidol in Human Brain Tissue

Neuroleptic malignant syndrome

1985 • 981 citations

Central D2-Dopamine Receptor Occupancy in Schizophrenic Patients Treated With Antipsychotic Drugs

1988 • 692 citations

Optimal Dose of Neuroleptic in Acute Schizophrenia

1991 • 384 citations

Bayesian Individualization of Pharmacokinetics: Simple Implementation and Comparison with Non-Bayesian Methods

1982 • 290 citations

Neuroleptic malignant syndrome: review and analysis of 115 cases

1987 • 289 citations

Clinical Risk Following Abrupt and Gradual Withdrawal of Maintenance Neuroleptic Treatment

1997 • 245 citations

Human brain fluoxetine concentrations

1993 • 197 citations

Population pharmacokinetics: theory and practice.

1991 • 191 citations

3H-spiperone binding sites in post-mortem brains from schizophrenic patients: Relationship to neuroleptic drug treatment, abnormal movements, and positive symptoms

1989 • 189 citations

Spiperone: A ligand of choice for neuroleptic receptors

1978 • 178 citations

Identification of a potentially neurotoxic pyridinium metabolite of haloperidol in rats

1990 • 132 citations

MPP(+)-like neurotoxicity of a pyridinium metabolite derived from haloperidol: in vivo microdialysis and in vitro mitochondrial studies.

1994 • 121 citations

Pharmacokinetic studies on haloperidol in man.

1976 • 119 citations

Striatal dopamine receptor occupancy during and following withdrawal from neuroleptic treatment: correlative evaluation by positron emission tomography and plasma prolactin levels

1989 • 118 citations

Therapeutic brain concentration of the NMDA receptor antagonist amantadine

1995 • 109 citations

Studies on the in vitro conversion of haloperidol to a potentially neurotoxic pyridinium metabolite

1991 • 94 citations

Neurometabolic and behavioural effects of haloperidol in relation to drug levels in serum and brain

1977 • 88 citations

Reduced haloperidol in the post-mortem brains of haloperidol-treated patients

1984 • 75 citations

Drug distribution between blood and brain as a determinant of antipsychotic drug effects

1992 • 73 citations

In Vivo Assay for Neuroleptic Receptor Binding in the Striatum

1987 • 68 citations

1-Methyl-4-phenylpyridinium-like neurotoxicity of a pyridinium metabolite derived from haloperidol: cell culture and neurotransmitter uptake studies.

1994 • 66 citations

On the metabolism of haloperidol

1993 • 65 citations

Blood to brain distribution of neuroleptics

1987 • 63 citations

Differences between antipsychotic drugs in persistence of brain levels and behavioral effects

1992 • 61 citations

Plasma Haloperidol Levels and Clinical Effects in Schizophrenia and Schizoaffective Disorder

1995 • 55 citations

Slow accumulation of psychotropic substances in the human brain. Relationship to therapeutic latency of neuroleptic and antidepressant drugs?

1995 • 54 citations

Neuroleptic malignant syndrome

1994 • 51 citations

Delayed Normalization of Central D2 Dopamine Receptor Availability After Discontinuation of Haloperidol Decanoate

1997 • 50 citations

Formation of pyridinium species of haloperidol in human liver and brain

1996 • 47 citations

Two pyridinium metabolites of haloperidol are present in the brain of patients at post-mortem

1997 • 46 citations

Liquid chromatographic assay of phenothiazine, thioxanthene and butyrophenone neuroleptics and antihistamines in blood and plasma with conventional and radial compression columns and UV and electrochemical detection

1982 • 45 citations

Prolonged antidopaminergic actions of single doses of butyrophenones in the rat

1985 • 40 citations

Properties and Analysis of Haloperidol and Its Dosage Forms

1961 • 35 citations

Bioavailability of psychotropic drugs: historical perspective and pharmacokinetic overview.

1986 • 33 citations

Pimozide, a chemically novel, highly potent and orally long-acting neuroleptic drug. 3. Regional distribution of pimozide and of haloperidol in the dog brain.

1968 • 17 citations

Two cases of long term dopamine D2 receptor blockade after depot neuroleptics

1993 • 14 citations

Sensitive analysis of butyrophenone neuroleptics by high-performance liquid chromatography with ultraviolet detection at 254 nm

1985 • 8 citations