Ethanol impairs insulin-stimulated mitochondrial function in cerebellar granule neurons

Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill

1989 • 3,477 citations

Two CD95 (APO-1/Fas) signaling pathways

1998 • 3,045 citations

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

1997 • 2,442 citations

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1

1998 • 2,360 citations

IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

1998 • 1,394 citations

The Fetal Alcohol Syndrome

1978 • 1,371 citations

Insulin receptors are widely distributed in the central nervous system of the rat

1978 • 1,092 citations

The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation.

1996 • 592 citations

Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade

1998 • 531 citations

Correlates of p53- and Fas (CD95)-mediated apoptosis in Alzheimer's disease

1997 • 300 citations

Structural differences between insulin receptors in the brain and peripheral target tissues.

1983 • 265 citations

Superoxide anion is a natural inhibitor of FAS-mediated cell death.

1996 • 241 citations

Characterization of Insulin-Like Growth Factor Receptors in Rat Anterior Pituitary, Hypothalamus, and Brain*

1984 • 199 citations

P53- and CD95-associated apoptosis in neurodegenerative diseases.

1998 • 196 citations

Ethanol regulation of adenosine receptor-stimulated cAMP levels in a clonal neural cell line: an in vitro model of cellular tolerance to ethanol.

1986 • 190 citations

Chronic Ethanol Consumption Alters the Glutathione/Glutathione Peroxidase‐1 System and Protein Oxidation Status in Rat Liver

2001 • 168 citations

In Utero Ethanol Exposure Causes Mitochondrial Dysfunction, Which Can Result in Apoptotic Cell Death in Fetal Brain: A Potential Role for 4‐Hydroxynonenal

2001 • 158 citations

Mitochondrial glutathione depletion in alcoholic liver disease

1993 • 151 citations

Increased Oxidative Damage to Mitochondrial DNA Following Chronic Ethanol Consumption

1997 • 124 citations

Biochemical and Morphological Alterations of Baboon Hepatic Mitochondria After Chronic Ethanol Consumption

1984 • 120 citations

Nerve Growth Factor and Basic Fibroblast Growth Factor Protect Rat Cerebellar Granule Cells in Culture against Ethanol‐Induced Cell Death

1997 • 116 citations

Ethanol inhibits insulin-like growth factor-1-mediated signalling and proliferation of C6 rat glioblastoma cells.

1994 • 103 citations

Platelet-Derived Growth Factor-Mediated Signal Transduction Underlying Astrocyte Proliferation: Site of Ethanol Action

1999 • 102 citations

Ethanol-exposed central neurons fail to migrate and undergo apoptosis

1997 • 101 citations

Partial Rescue of Ethanol‐Induced Neuronal Apoptosis by Growth Factor Activation of Phosphoinositol‐3‐Kinase

2000 • 99 citations

Effect of ethanol on rat fetal hepatocytes: Studies on cell replication, lipid peroxidation and glutathione

1993 • 98 citations

Hydroxyethyl radicals in ethanol hepatotoxicity

1999 • 97 citations

Natural loss of Purkinje cells during development and increased loss with alcohol

1985 • 87 citations

Chronic ethanol consumption causes alterations in the structural integrity of mitochondrial DNA in aged rats

1999 • 80 citations

Potentiation by Chronic Ethanol Treatment of the Mitochondrial Permeability Transition

1999 • 77 citations

A Novel Small Molecule That Directly Sensitizes the Insulin Receptor In Vitro and In Vivo

2001 • 68 citations

Ethanol Impairs Insulin Receptor Substrate-1-Mediated Signal Transduction during Rat Liver Regeneration

1994 • 67 citations

Functional Properties of the Subtype of Insulin Receptor Found on Neurons

1988 • 64 citations

Chronic Ethanol Consumption Disturbs G–Protein Expression and Inhibits Cyclic Amp-Dependent Signaling in Regenerating Rat Liver

1992 • 62 citations

Ethanol inhibits insulin receptor substrate-1 tyrosine phosphorylation and insulin-stimulated neuronal thread protein gene expression

1995 • 58 citations

Ethanol Inhibition of Insulin Signaling in Hepatocellular Carcinoma Cells

1998 • 54 citations

Oxygen Free Radical Injury Is Sufficient to Cause Some Alzheimer-Type Molecular Abnormalities in Human CNS Neuronal Cells

2000 • 45 citations

Ethanol Induces Cell Death and Cell Cycle Delay in Cultures of Pheochromocytoma PC12 Cells

1999 • 44 citations

Differential Effects of Ethanol on Insulin‐Signaling Through the Insulin Receptor Substrate‐1

1999 • 37 citations

Influence of ethanol on insulin receptor substrate-1-mediated signal transduction during rat liver regeneration.

1994 • 32 citations

Effects of ethanol metabolism on PKC activity in isolated rat hepatocytes

1996 • 16 citations

Ethanol decreases the expression of mitochondrial cytochrome c oxidase mRNA in the rat

2001 • 16 citations

Troglitazone improves whole-body insulin resistance and skeletal muscle glucose use in type II diabetic patients.

2001 • 11 citations