Ethanol Inhibition of Insulin Signaling in Hepatocellular Carcinoma Cells

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

1997 • 2,442 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

The insulin signaling system.

1994 • 1,733 citations

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1991 • 1,590 citations

The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling

1985 • 1,485 citations

Requirement for Phosphatidylinositol-3 Kinase in the Prevention of Apoptosis by Nerve Growth Factor

1995 • 1,400 citations

Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin.

1994 • 923 citations

Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cells.

1985 • 888 citations

The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling.

1993 • 705 citations

Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells

1985 • 665 citations

The Function of GRB2 in Linking the Insulin Receptor to Ras Signaling Pathways

1993 • 629 citations

Insulin-like growth factors and cancer

1992 • 622 citations

Ras-Dependent Induction of Cellular Responses by Constitutively Active Phosphatidylinositol-3 Kinase

1995 • 553 citations

Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1.

1993 • 452 citations

Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation.

1990 • 404 citations

The origin, hormonal nature, and action of hepatotrophic substances in portal venous blood.

1973 • 366 citations

Regulation of hepatic regeneration in rats by synergistic action of insulin and glucagon.

1975 • 329 citations

The IRS-1 signaling system

1994 • 310 citations

Insulin-induced phosphorylation of the 46- and 52-kDa Shc proteins.

1993 • 308 citations

Binding of the Ras Activator Son of Sevenless to Insulin Receptor Substrate-1 Signaling Complexes

1993 • 298 citations

Insulin-Stimulated GLUT4 Translocation Is Relevant to the Phosphorylation of IRS-1 and the Activity of PI3 Kinase

1993 • 277 citations

Blood ethanol levels in sober alcohol users seen in an emergency room

1981 • 262 citations

The phosphatidylinositol 3-kinase serine kinase phosphorylates IRS-1. Stimulation by insulin and inhibition by Wortmannin.

1994 • 234 citations

The New Elements of Insulin Signaling: Insulin Receptor Substrate-1 and Proteins With SH2 Domains

1993 • 221 citations

Ethanol-induced mobilization of calcium by activation of phosphoinositide-specific phospholipase C in intact hepatocytes.

1987 • 202 citations

Identification of c-fos sequences involved in induction by insulin and phorbol esters.

1988 • 184 citations

Ras Activation by Insulin and Epidermal Growth Factor through Enhanced Exchange of Guanine Nucleotides on p21^ras

1993 • 176 citations

Inhibition of hepatic regeneration in rats by acute and chronic ethanol intoxication

1979 • 176 citations

Phosphatidylinositol-3-kinase in isolated rat adipocytes. Activation by insulin and subcellular distribution.

1992 • 137 citations

Growth Hormone Stimulates the Tyrosine Phosphorylation of the Insulin Receptor Substrate-1 and Its Association with Phosphatidylinositol 3-Kinase in Primary Adipocytes

1995 • 134 citations

Essential role of phosphatidylinositol 3‐kinase in insulin‐induced activation and phosphorylation of the cGMP‐inhibited cAMP phosphodiesterase in rat adipocytes studies using the selective inhibitor wortmannin

1994 • 128 citations

Inhibition of liver regeneration by chronic alcohol administration.

1982 • 127 citations

Biological effects of human insulin receptor substrate-1 overexpression in hepatocytes

1997 • 104 citations

Ethanol inhibits insulin-like growth factor-1-mediated signalling and proliferation of C6 rat glioblastoma cells.

1994 • 103 citations

Cloning and increased expression of an insulin receptor substrate-1-like gene in human hepatocellular carcinoma

1994 • 101 citations

Ras activation by insulin and epidermal growth factor through enhanced exchange of guanine nucleotides on p21ras.

1993 • 97 citations

Ethanol causes desensitization of receptor-mediated phospholipase C activation in isolated hepatocytes

1991 • 91 citations

Hepatic proliferative response to insulin in severe alloxan diabetes.

1966 • 91 citations

Overexpression of Human Insulin Receptor Substrate 1 Induces Cellular Transformation with Activation of Mitogen-Activated Protein Kinases

1996 • 88 citations

Establishment and characterization of a new human hepatocellular carcinoma cell line

1984 • 80 citations

Insulin and 12-O-tetradecanoylphorbol-13-acetate activation of two immunologically distinct myelin basic protein/microtubule-associated protein 2 (MBP/MAP2) kinases via de novo phosphorylation of threonine and tyrosine residues.

1991 • 77 citations

A carboxy-terminal truncated insulin receptor substrate-1 dominant negative protein reverses the human hepatocellular carcinoma malignant phenotype.

1996 • 73 citations

Ethanol Impairs Insulin Receptor Substrate-1-Mediated Signal Transduction during Rat Liver Regeneration

1994 • 67 citations

Chronic Ethanol Consumption Disturbs G–Protein Expression and Inhibits Cyclic Amp-Dependent Signaling in Regenerating Rat Liver

1992 • 62 citations

Ethanol inhibits insulin receptor substrate-1 tyrosine phosphorylation and insulin-stimulated neuronal thread protein gene expression

1995 • 58 citations

Ethanol inhibits hormone stimulated hepatocyte DNA synthesis

1985 • 56 citations

Insulin activates p21Ras and guanine nucleotide releasing factor in cells expressing wild type and mutant insulin receptors.

1993 • 53 citations

Differential inhibition of epidermal growth factor signaling pathways in rat hepatocytes by long-term ethanol treatment

1997 • 51 citations

Ethanol Alters Hormone Production in Cultured Human Placental Trophoblasts

1993 • 42 citations

Cellular expression of mutant insulin receptors interferes with the rapid transcriptional response to both insulin and insulin-like growth factor I.

1991 • 33 citations

Influence of ethanol on insulin receptor substrate-1-mediated signal transduction during rat liver regeneration.

1994 • 32 citations

Tyrosine Phosphorylation of pp185 by Insulin Receptor Kinase in a Cell-free System

1989 • 24 citations

Mutant of Insulin Receptor Substrate-1 Incapable of Activating Phosphatidylinositol 3-Kinase Did Not Mediate Insulin-stimulated Maturation of Xenopus laevis Oocytes

1996 • 23 citations