Prognostic Impact of Microsatellite Instability and DNA Ploidy in Human Colon Carcinoma Patients

Regression Models and Life-Tables

1992 • 27,454 citations

Regression Models and Life-Tables

1972 • 27,145 citations

Lessons from Hereditary Colorectal Cancer

1996 • 4,900 citations

Proportional hazards tests and diagnostics based on weighted residuals

1994 • 4,890 citations

A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer.

1998 • 4,047 citations

Cancer Statistics, 2004

2004 • 4,026 citations

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

1993 • 2,711 citations

Method for analysis of cellular DNA content of paraffin-embedded pathological material using flow cytometry.

1983 • 2,066 citations

Tumor Microsatellite-Instability Status as a Predictor of Benefit from Fluorouracil-Based Adjuvant Chemotherapy for Colon Cancer

2003 • 2,056 citations

Genetic instability in colorectal cancers

1997 • 1,989 citations

Mutations of mitotic checkpoint genes in human cancers

1998 • 1,482 citations

Tumor Microsatellite Instability and Clinical Outcome in Young Patients with Colorectal Cancer

2000 • 1,352 citations

THE PROGNOSTIC SIGNIFICANCE OF DIRECT EXTENSION OF CARCINOMA OF THE COLON AND RECTUM

1954 • 1,110 citations

Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability.

1998 • 855 citations

Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences.

1994 • 807 citations

Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history.

1993 • 796 citations

Immunohistochemistry Versus Microsatellite Instability Testing in Phenotyping Colorectal Tumors

2002 • 716 citations

American Joint Committee on Cancer prognostic factors consensus conference

2000 • 587 citations

Evaluation of a Large, Population-Based Sample Supports a CpG Island Methylator Phenotype in Colon Cancer

2005 • 571 citations

Microsatellite instability in colorectal cancer: different mutator phenotypes and the principal involvement of hMLH1.

1998 • 523 citations

Mismatch repair proficiency and in vitro response to 5-fluorouracil

1999 • 416 citations

Microsatellite Instability and 8p Allelic Imbalance in Stage B2 and C Colorectal Cancers

1999 • 375 citations

Better survival rates in patients with MLH1-associated hereditary colorectal cancer

1996 • 362 citations

Microsatellite instability is a favorable prognostic indicator in patients with colorectal cancer receiving chemotherapy

2000 • 352 citations

The Frequency of Hereditary Defective Mismatch Repair in a Prospective Series of Unselected Colorectal Carcinomas

2001 • 343 citations

Genetic and Epigenetic Modification of MLH1 Accounts for a Major Share of Microsatellite-Unstable Colorectal Cancers

2000 • 286 citations

Centrosome amplification and the development of cancer

2002 • 277 citations

CpG island methylator phenotype is an independent predictor of survival benefit from 5-fluorouracil in stage III colorectal cancer.

2003 • 263 citations

Characterization of sporadic colon cancer by patterns of genomic instability.

2003 • 259 citations

Low-level microsatellite instability in most colorectal carcinomas.

2002 • 191 citations

Different genetic pathways to proximal and distal colorectal cancer influenced by sex-related factors

1997 • 184 citations

DNA mismatch repair and cancer

1995 • 178 citations

Investigation of the Prognostic and Predictive Value of Thymidylate Synthase, p53, and Ki-67 in Patients With Locally Advanced Colon Cancer

2002 • 177 citations

DNA ploidy and cell kinetic measurements as predictors of recurrence and survival in stages B2 and C colorectal adenocarcinoma

1991 • 158 citations

Mucinous carcinoma of the colon: correlation of loss of mismatch repair enzymes with clinicopathologic features and survival

2004 • 147 citations

<i>p53</i> Gene Mutation, Microsatellite Instability and Adjuvant Chemotherapy: Impact on Survival of 388 Patients with Dukes’ C Colon Carcinoma

2000 • 146 citations

Colorectal Cancer

1987 • 142 citations

Prognostic implications of proliferative activity and DNA aneuploidy in colonic adenocarcinomas.

1987 • 132 citations

Epigenetic phenotypes distinguish microsatellite-stable and -unstable colorectal cancers

1999 • 129 citations

Prognostic Value of Proliferation, Apoptosis, Defective DNA Mismatch Repair, and p53 Overexpression in Patients With Resected Dukes' B2 or C Colon Cancer

2004 • 126 citations

Prognostic significance of p53 mutations in colon cancer at the population level

2002 • 125 citations

Low-level microsatellite instability occurs in most colorectal cancers and is a nonrandomly distributed quantitative trait.

2002 • 124 citations

Retrospective analysis of the prognostic significance of DNA content and proliferative activity in large bowel carcinoma.

1987 • 116 citations

Apoptotic and mitotic indices predict survival rates in lymph node-negative colon carcinomas.

1999 • 88 citations

Prognostic significance of DNA ploidy in patients with stage II and stage III colon carcinoma

1998 • 79 citations

Computerized nuclear morphometry is a useful technique for evaluating the high metastatic potential of colorectal adenocarcinoma

1999 • 41 citations

The influence of tumour cell DNA content on survival in colorectal cancer: a detailed analysis

1990 • 32 citations