Expression and Control of Vascular Endothelial Cells: Proliferation and Differentiation by Fibroblast Growth Factors

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

1986 • 2,878 citations

Autocrine growth factors and cancer

1985 • 1,462 citations

Structural Characterization and Biological Functions of Fibroblast Growth Factor

1987 • 1,299 citations

Transforming growth factor type beta induces monocyte chemotaxis and growth factor production.

1987 • 1,287 citations

Transforming Growth Factor-β: Biological Function and Chemical Structure

1986 • 1,198 citations

Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth.

1980 • 1,195 citations

Identity of tumour necrosis factor and the macrophage-secreted factor cachectin

1985 • 1,125 citations

Endothelial cell-derived basic fibroblast growth factor: synthesis and deposition into subendothelial extracellular matrix.

1987 • 1,045 citations

Nucleotide Sequence of a Bovine Clone Encoding the Angiogenic Protein, Basic Fibroblast Growth Factor

1986 • 1,032 citations

Mesoderm induction in early Xenopus embryos by heparin-binding growth factors

1987 • 953 citations

Heparin Affinity: Purification of a Tumor-Derived Capillary Endothelial Cell Growth Factor

1984 • 937 citations

Synergistic induction of mesoderm by FGF and TGF-β and the identification of an mRNA coding for FGF in the early xenopus embryo

1987 • 883 citations

Heparin protects basic and acidic FGF from inactivation

1986 • 856 citations

Basic fibroblast growth factor induces angiogenesis in vitro.

1986 • 828 citations

Endothelial cell-derived heparan sulfate binds basic fibroblast growth factor and protects it from proteolytic degradation.

1988 • 810 citations

Human Endothelial Cells: Use of Heparin in Cloning and Long-Term Serial Cultivation

1983 • 801 citations

Localisation of a fibroblast growth factor and its effect alone and with hydrocortisone on 3T3 cell growth

1974 • 786 citations

Capillary endothelial cells express basic fibroblast growth factor, a mitogen that promotes their own growth

1987 • 764 citations

The relation between cell proliferation and the vascular system in a transplanted mouse mammary tumour

1968 • 764 citations

Tumor Growth and Neovascularization: An Experimental Model Using the Rabbit Cornea 2

1974 • 762 citations

How is blood vessel growth regulated in normal and neoplastic tissue? G.H.A. Clowes memorial Award lecture.

1986 • 744 citations

Tumor necrosis factor type alpha, a potent inhibitor of endothelial cell growth in vitro, is angiogenic in vivo.

1987 • 718 citations

Primary structure of bovine pituitary basic fibroblast growth factor (FGF) and comparison with the amino-terminal sequence of bovine brain acidic FGF.

1985 • 710 citations

Cultured endothelial cells produce heparinlike inhibitor of smooth muscle cell growth

1981 • 685 citations

Human Endothelial Cell Growth Factor: Cloning, Nucleotide Sequence, and Chromosome Localization

1986 • 679 citations

The TGF-β family of growth and differentiation factors

1987 • 675 citations

Isolation of brain fibroblast growth factor by heparin-Sepharose affinity chromatography: identity with pituitary fibroblast growth factor.

1984 • 624 citations

Human basic fibroblast growth factor: nucleotide sequence and genomic organization.

1986 • 604 citations

An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family

1987 • 525 citations

Trans-filter induction of tubules in mouse metanephrogenic mesenchyme

1956 • 521 citations

Basic fibroblast growth factor from human keratinocytes is a natural mitogen for melanocytes.

1988 • 489 citations

Effect of Oxygen on Developing Retinal Vessels with Particular Reference to the Problem of Retrolental Fibroplasia

1954 • 486 citations

Molecular and biological characterization of fibroblast growth factor, an angiogenic factor which also controls the proliferation and differentiation of mesoderm and neuroectoderm derived cells

1986 • 472 citations

Vasculae Reactions of Normal and Malignant Tissues in Vivo. I. Vascular Reactions of Mice to Wounds and to Normal and Neoplastic Transplants

1945 • 466 citations

The mode of development of the vascular system of the retina, with some observations on its significance for certain retinal diseases

1948 • 456 citations

Inhibition of Endothelial Regeneration by Type-Beta Transforming Growth Factor from Platelets

1986 • 439 citations

The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors.

1988 • 425 citations

Clonal growth of bovine vascular endothelial cells: fibroblast growth factor as a survival agent.

1976 • 423 citations

Relation of vascular proliferation to tumor growth.

1976 • 413 citations

The opposing effects of basic fibroblast growth factor and transforming growth factor beta on the regulation of plasminogen activator activity in capillary endothelial cells.

1987 • 378 citations

Immunoreactive fibroblast growth factor in cells of peritoneal exudate suggests its identity with macrophage-derived growth factor

1985 • 372 citations

Factors involved in the modulation of cell proliferation in vivo and in vitro: The role of fibroblast and epidermal growth factors in the proliferative response of mammalian cells

1978 • 360 citations

Tumorigenesis by mouse mammary tumor virus: Proviral activation of a cellular gene in the common integration region int-2

1984 • 356 citations

Basic and acidic fibroblast growth factors interact with the same cell surface receptors.

1986 • 340 citations

Brain-Derived Acidic Fibroblast Growth Factor: Complete Amino Acid Sequence and Homologies

1985 • 335 citations

Inhibitory action of transforming growth factor beta on endothelial cells.

1987 • 324 citations

An antiproliferative heparan sulfate species produced by postconfluent smooth muscle cells.

1985 • 315 citations

Transforming growth factor-beta inhibits endothelial cell proliferation

1986 • 313 citations

Inhibition of endothelial cell proliferation by type β-transforming growth factor: Interactions with acidic and basic fibroblast growth factors

1986 • 312 citations

Control of proliferation of human vascular endothelial cells. Characterization of the response of human umbilical vein endothelial cells to fibroblast growth factor, epidermal growth factor, and thrombin

1978 • 312 citations

Pure brain-derived acidic fibroblast growth factor is a potent angiogenic vascular endothelial cell mitogen with sequence homology to interleukin 1.

1985 • 294 citations

cDNA sequence of human transforming gene hst and identification of the coding sequence required for transforming activity.

1987 • 293 citations

Inhibition of endothelial cell proliferation by gamma-interferon.

1987 • 292 citations

Differential efficacies of human type I and type II interferons as antiviral and antiproliferative agents.

1980 • 286 citations

Effect of fibroblast growth factor and lipoproteins on the proliferation of endothelial cells derived from bovine adrenal cortex, brain cortex, and corpus luteum capillaries

1986 • 273 citations

Purification from a human hepatoma cell line of a basic fibroblast growth factor-like molecule that stimulates capillary endothelial cell plasminogen activator production, DNA synthesis, and migration.

1986 • 272 citations

Retina- and eye-derived endothelial cell growth factors: partial molecular characterization and identity with acidic and basic fibroblast growth factors

1985 • 268 citations

Purification and characterization of heparin-binding endothelial cell growth factors.

1986 • 263 citations

The angiogenic activity of the fibroblast and epidermal growth factor

1979 • 261 citations

Corpus Luteum Angiogenic Factor Is Related to Fibroblast Growth Factor*

1985 • 260 citations

Identification, localization, and role of fibronectin in cultured bovine endothelial cells.

1978 • 258 citations

Both normal and tumor cells produce basic fibroblast growth factor

1986 • 250 citations

Human tumor cells synthesize an endothelial cell growth factor that is structurally related to basic fibroblast growth factor.

1986 • 247 citations

Vascularization of normal and neoplastic tissues grafted to the chick chorioallantois. Role of host and preexisting graft blood vessels.

1975 • 233 citations

Aortic endothelial cells synthesize basic fibroblast growth factor which remains cell associated and platelet‐derived growth factor‐like protein which is secreted

1987 • 229 citations

Differentiation and vascularization of the metanephric kidney grafted on the chorioallantoic membrane

1983 • 226 citations

BALB and kirsten murine sarcoma viruses alter growth and differentiation of EGF-dependent BALB/c mouse epidermal keratinocyte lines

1983 • 224 citations

Primary structure of bovine brain acidic fibroblast growth factor (FGF)

1985 • 213 citations

The changes in the vascular pattern of the ovary of the albino rat during the estrous cycle

1943 • 212 citations

Two proto-oncogenes implicated in mammary carcinogenesis, int-1 and int-2, are independently regulated during mouse development.

1986 • 211 citations

Degradation of heparan sulfate in the subendothelial extracellular matrix by a readily released heparanase from human neutrophils. Possible role in invasion through basement membranes.

1985 • 210 citations

Control of Bovine Adrenal Cortical Cell Proliferation by Fibroblast Growth Factor. Lack of Effect of Epidermal Growth Factor

1977 • 201 citations

Pituitary follicular cells produce basic fibroblast growth factor.

1987 • 200 citations

Human vascular smooth muscle cells both express and respond to heparin-binding growth factor I (endothelial cell growth factor).

1987 • 194 citations

Effect of high and low density lipoproteins on proliferation of cultured bovine vascular endothelial cells.

1980 • 185 citations

Induction of angiogenesis by bovine brain derived class 1 heparin-binding growth factor

1985 • 180 citations

Acidic fibroblast growth factor (FGF) from bovine brain: amino-terminal sequence and comparison with basic FGF.

1985 • 178 citations

Bovine Granulosa Cells Produce Basic Fibroblast Growth Factor*

1987 • 175 citations

Production a corpus luteum angiogenic factor responsible for proliferation of capillaries and neovascularization of the corpus luteum.

1978 • 174 citations

A neuronal cell surface heparan sulfate proteoglycan is required for dorsal root ganglion neuron stimulation of Schwann cell proliferation.

1985 • 171 citations

Angiogenic activity from bovine retina: partial purification and characterization.

1981 • 154 citations

Basic fibroblast growth factor in human rhabdomyosarcoma cells: implications for the proliferation and neovascularization of myoblast-derived tumors.

1987 • 151 citations

Heparin protects heparin-binding growth factor-I from proteolytic inactivation in vitro

1988 • 149 citations

Isolation of Fibroblast Growth Factor from Bovine Adrenal Gland: Physicochemical and Biological Characterization*

1986 • 145 citations

Dual origin of glomerular basement membrane

1984 • 144 citations

Growth Factors and the Extracellular Matrix

1980 • 142 citations

[9] Isolation and characterization of acidic and basic fibroblast growth factor

1987 • 139 citations

Interaction of T lymphocytes and macrophages with cultured vascular endothelial cells: Attachment, invasion, and subsequent degradation of the subendothelial extracellular matrix

1984 • 133 citations

Shift in collagen type as an early response to induction of the metanephric mesenchyme.

1981 • 133 citations

Defective macromolecule biosynthesis and cell-cycle progression in a mammalian cell starved for mevalonate.

1985 • 133 citations

The extracellular matrix and the control of proliferation of vascular endothelial and vascular smooth muscle cells

1980 • 129 citations

Mitogenic effect of fibroblast growth factor on early passage cultures of human and murine fibroblasts.

1975 • 129 citations

The Endothelial Cells of Large and Small Blood Vessels

1981 • 126 citations

Inductive effects of fibroblast growth factor and lithium ion on Xenopus blastula ectoderm

1988 • 126 citations

The origin of the glomerular endothelium

1982 • 124 citations

Human brain-derived acidic and basic fibroblast growth factors: Amino terminal sequences and specific mitogenic activities

1986 • 112 citations

Initiation of Angiogenesis by Human Follicular Fluid

1984 • 111 citations

Is There a Ubiquitous Growth Factor in the Eye?

1981 • 111 citations

Vascular endothelial cells maintained in the absence of fibroblast growth factor undergo structural and functional alterations that are incompatible with their in vivo differentiated properties.

1979 • 108 citations

Neurite outgrowth and protein synthesis by PC12 cells as a function of substratum and nerve growth factor

1982 • 106 citations

Production of a heparin-binding angiogenesis factor by the embryonic kidney.

1986 • 105 citations

Are factors originating from serum, plasma, or cultured cells involved in the growth‐promoting effect of the extracellular matrix produced by cultured bovine corneal endothelial cells?

1983 • 105 citations

Isolation and partial characterization of an endothelial cell growth factor from the bovine kidney: homology with basic fibroblast growth factor

1985 • 93 citations

Tumor necrosis factor inhibits the proliferation of cultured capillary endothelial cells

1987 • 91 citations

Characterization of collagens synthesized by cultured bovine corneal endothelial cells.

1981 • 89 citations

The complete amino acid sequence of human brain-derived acidic fibroblast growth factor

1986 • 85 citations

Characterization of Cultured Bovine Adrenocortical Cells and Derived Clonal Lines: Regulation of Steroidogenesis and Culture Life Span*

1979 • 80 citations

Human Basic Fibroblast Growth Factor: Nucleotide Sequence, Genomic Organization, and Expression in Mammalian Cells

1986 • 79 citations

Degradation of sulfated proteoglycans in the subendothelial extracellular matrix by human platelet heparitinase.

1984 • 78 citations

Basic fibroblast growth factor: Expression in cultured cells derived from corneal endothelium and lens epithelium

1988 • 77 citations

High density lipoproteins and the growth of vascular endothelial cells in serum-free medium

1981 • 76 citations

Isolation of an amino terminal extended form of basic fibroblast growth factor

1986 • 74 citations

Biological effects of γ‐interferon on human tumor cells: Quantity and affinity of cell membrane receptors for γ‐IFN in relation to growth inhibition and induction of HLA‐DR expression

1985 • 71 citations

Demonstration of angiogenesis-activity in the corpus luteum of cattle

1977 • 67 citations

Basic Fibroblast Growth Factor: Production and Growth Stimulation in Cultured Adrenal Cortex Cells*

1987 • 66 citations

Correlation between two effects of high density lipoproteins on vascular endothelial cells. The induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and the support of cellular proliferation.

1982 • 65 citations

Effect of p-nitrophenyl-beta-D-xyloside on proteoglycan synthesis and extracellular matrix formation by bovine corneal endothelial cell cultures.

1984 • 60 citations

Glycosaminoglycans synthesized by cultured bovine corneal endothelial cells

1983 • 60 citations

Appearance in confluent vascular endothelial cell monolayers of a specific cell surface protein (CSP-60) not detected in actively growing endothelial cells or in cell types growing in multiple layers.

1979 • 59 citations

Conditioned medium from endothelial cell cultures can restore the normal phenotypic expression of vascular endothelium maintained in vitro in the absence of fibroblast growth factor

1980 • 59 citations

Isolation and characterization of a mammalian cell mutant defective in 3-hydroxy-3-methylglutaryl coenzyme A synthase.

1982 • 58 citations

Structural and functional alterations in the surface of vascular endothelial cells associated with the formation of a confluent cell monolayer and with the withdrawal of fibroblast growth factor

1979 • 56 citations

Inactivation of a basement membrane component responsible for cell proliferation but not for cell attachment

1982 • 51 citations

Brain-derived fibroblast growth factor: A study of its inactivation

1983 • 50 citations

Peptide growth factors PDGF, EGF, and FGF regulate interferon-gamma production.

1985 • 47 citations

Humoral control of cell proliferation: the role of fibroblast growth factor in regeneration, angiogenesis, wound healing, and neoplastic growth.

1976 • 46 citations

Effect of retina-derived basic and acidic fibroblast growth factor and lipoproteins on the proliferation of retina-derived capillary endothelial cells

1986 • 41 citations

Eye-Derived Growth Factor Isolated from Bovine Retina and Used for Epidermal Wound Healing In Vivo

1986 • 39 citations

Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in vascular endothelial cells. Separate sterol and non-sterol components.

1982 • 36 citations

Growth factors and the vessel wall.

1982 • 29 citations

Amino acid sequence of human acidic fibroblast growth factor

1986 • 25 citations

Utilization of the chick chorioallantoic membrane for in vitro growth of the embryonic murine kidney

1980 • 24 citations

Stimulation of the proliferation of the madin‐darby canine kidney (MDCK) epithelial cell line by high‐density lipoproteins and their induction of 3‐hydroxy‐3‐methylglutaryl coenzyme a reductase activity

1983 • 22 citations

Biotin and choline replace the growth requirement of Madin‐Darby canine kidney cells for high‐density lipoproteins

1985 • 11 citations

Effect of Albumin Microinfusion on Proximal Tubular Pressure

1982 • 4 citations