CCR4, a 3′-5′ poly(A) RNA and ssDNA exonuclease, is the catalytic component of the cytoplasmic deadenylase

Conserved Structures and Diversity of Functions of RNA-Binding Proteins

1994 • 1,873 citations

Human L1 Retrotransposon Encodes a Conserved Endonuclease Required for Retrotransposition

1996 • 1,093 citations

DNA-bound structures and mutants reveal abasic DNA binding by APE1 DNA repair and coordination

2000 • 700 citations

The Transcription Factor Associated Ccr4 and Caf1 Proteins Are Components of the Major Cytoplasmic mRNA Deadenylase in Saccharomyces cerevisiae

2001 • 574 citations

RNA polymerase II and the integration of nuclear events

2000 • 561 citations

Exoribonuclease superfamilies: structural analysis and phylogenetic distribution

2001 • 491 citations

Structure and function of the multifunctional DNA-repair enzyme exonuclease III

1995 • 382 citations

The DCP2 protein is required for mRNA decapping in Saccharomyces cerevisiae and contains a functional MutT motif

1999 • 365 citations

Ccr4p is the catalytic subunit of a Ccr4p/Pop2p/Notp mRNA deadenylase complex inSaccharomyces cerevisiae

2002 • 325 citations

The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites

1997 • 316 citations

The proofreading domain of Escherichia coli DNA polymerase I and other DNA and/or RNA exonuclease domains

1997 • 234 citations

The NOT proteins are part of the CCR4 transcriptional complex and affect gene expression both positively and negatively

1998 • 207 citations

NOT1(CDC39), NOT2(CDC36), NOT3, and NOT4 encode a global-negative regulator of transcription that differentially affects TATA-element utilization.

1994 • 199 citations

The yeast POP2 gene encodes a nuclease involved in mRNA deadenylation

2001 • 196 citations

IDENTIFICATION OF NEW GENES INVOLVED IN THE REGULATION OF YEAST ALCOHOL DEHYDROGENASE II

1984 • 167 citations

A Complex Containing RNA Polymerase II, Paf1p, Cdc73p, Hpr1p, and Ccr4p Plays a Role in Protein Kinase C Signaling

1999 • 164 citations

Functionally unrelated signalling proteins contain a fold similar to Mg2+-dependent endonucleases

2000 • 163 citations

Cleavage/polyadenylation factor IA associates with the carboxyl-terminal domain of RNA polymerase II in Saccharomyces cerevisiae

2001 • 155 citations

Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits

2000 • 151 citations

The CCR4 and CAF1 Proteins of the CCR4-NOT Complex Are Physically and Functionally Separated from NOT2, NOT4, and NOT5

1999 • 150 citations

Dhh1p, a Putative RNA Helicase, Associates with the General Transcription Factors Pop2p and Ccr4p from Saccharomyces cerevisiae

1998 • 144 citations

Purification and characterization of the 1.0 MDa CCR4-NOT complex identifies two novel components of the complex 1 1Edited by D. Draper

2001 • 142 citations

Identification of critical active-site residues in the multifunctional human DNA repair enzyme HAP1

1995 • 130 citations

The CCR4 gene from Saccharomyces cerevisiae is required for both nonfermentative and spt-mediated gene expression.

1990 • 113 citations

Characterization of CAF4 and CAF16 Reveals a Functional Connection between the CCR4-NOT Complex and a Subset of SRB Proteins of the RNA Polymerase II Holoenzyme

2001 • 109 citations

Identification of a Mouse Protein Whose Homolog in Saccharomyces cerevisiae Is a Component of the CCR4 Transcriptional Regulatory Complex

1995 • 109 citations

CDC39, an essential nuclear protein that negatively regulates transcription and differentially affects the constitutive and inducible HIS3 promoters.

1993 • 109 citations

DBF2, a cell cycle-regulated protein kinase, is physically and functionally associated with the CCR4 transcriptional regulatory complex

1997 • 106 citations

A 54-kDa Fragment of the Poly(A)-specific Ribonuclease Is an Oligomeric, Processive, and Cap-interacting Poly(A)-specific 3′ Exonuclease

2000 • 99 citations

Abasic Site Binding by the Human Apurinic Endonuclease, Ape, and Determination of the DNA Contact Sites

1997 • 92 citations

Cleavage/polyadenylation factor IA associates with the carboxyl-terminal domain of RNA polymerase II in Saccharomycescerevisiae

2001 • 89 citations

CCR4 is a glucose-regulated transcription factor whose leucine-rich repeat binds several proteins important for placing CCR4 in its proper promoter context.

1994 • 88 citations

Genetic Evidence Supports a Role for the Yeast CCR4-NOT Complex in Transcriptional Elongation

2001 • 83 citations

Functional Interaction of CCR4-NOT Proteins With TATAA-Binding Protein (TBP) and Its Associated Factors in Yeast

2000 • 80 citations

The Inositol Polyphosphate 5-Phosphatases and the Apurinic/Apyrimidinic Base Excision Repair Endonucleases Share a Common Mechanism for Catalysis

2000 • 76 citations

Target DNA chromatinization modulates nicking by L1 endonuclease

2001 • 71 citations

Mapping the protein-DNA interface and the metal-binding site of the major human apurinic/apyrimidinic endonuclease

2000 • 64 citations

Molecular analysis ofPOP2gene, a gene required for glucose-derepression of gene expression inSaccharomyces cerevisiae

1992 • 64 citations

The CCR4 protein from Saccharomyces cerevisiae contains a leucine-rich repeat region which is required for its control of ADH2 gene expression.

1992 • 54 citations

The TBP associated factor "yTaf II 19p" functionally interacts with components of the global transcriptional regulator "the Ccr4-Not complex" and physically interacts with the Not5 subunit

2000 • 50 citations

Single-Turnover Analysis of Mutant Human Apurinic/Apyrimidinic Endonuclease^,

1999 • 44 citations

The TATA-binding Protein-associated Factor yTafII19p Functionally Interacts with Components of the Global Transcriptional Regulator Ccr4-Not Complex and Physically Interacts with the Not5 Subunit

2000 • 37 citations

CCR4 Is a Glucose-Regulated Transcription Factor Whose Leucine-Rich Repeat Binds Several Proteins Important for Placing CCR4 in Its Proper Promoter Context

1994 • 33 citations

Characterization of a Mammalian Gene Related to the Yeast CCR4 General Transcription Factor and Revealed by Transposon Insertion

1999 • 28 citations

Identification of a novel Drosophila melanogaster gene, angel, a member of a nested gene cluster at locus 59F4,5

1996 • 15 citations