The antioxidant LY231617 reduces global ischemic neuronal injury in rats.

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

1991 • 2,173 citations

A new model of bilateral hemispheric ischemia in the unanesthetized rat.

1979 • 1,934 citations

Rat hippocampal neurons in dispersed cell culture

1977 • 1,106 citations

An improved method to determine cell viability by simultaneous staining with fluorescein diacetate-propidium iodide.

1985 • 1,068 citations

Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress

1989 • 987 citations

Glutamate becomes neurotoxic via the N-methyl-d-aspartate receptor when intracellular energy levels are reduced

1988 • 972 citations

Autoxidation versus covalent binding of quinones as the mechanism of toxicity of dopamine, 6-hydroxydopamine, and related compounds toward C1300 neuroblastoma cells in vitro.

1978 • 936 citations

Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia/reperfusion-induced injury to gerbil brain.

1990 • 787 citations

Effect of Ischemia on the In Vivo Release of Striatal Dopamine, Glutamate, and γ‐Aminobutyric Acid Studied by Intracerebral Microdialysis

1988 • 704 citations

Mechanism of Kainate Toxicity to Cerebellar Neurons In Vitro Is Analogous to Reperfusion Tissue Injury

1987 • 334 citations

Oxygen radicals in cerebral ischemia

1992 • 332 citations

Substantia nigra lesion protects against ischemic damage in the striatum

1987 • 267 citations

Liposome-entrapped superoxide dismutase reduces cerebral infarction in cerebral ischemia in rats.

1990 • 266 citations

Mechanism of calcium potentiation of oxygen free radical injury to renal mitochondria. A model for post-ischemic and toxic mitochondrial damage.

1986 • 258 citations

Antioxidants protect against glutamate-induced cytotoxicity in a neuronal cell line.

1989 • 245 citations

Increased lipid peroxidation in vulnerable brain regions after transient forebrain ischemia in rats.

1989 • 237 citations

Relationship between free radical production and lipid peroxidation during ischemia-reperfusion injury in the rat brain

1991 • 216 citations

Xanthine oxidase-derived hydrogen peroxide contributes to ischemia reperfusion-induced edema in gerbil brains.

1988 • 208 citations

Activation of Ethanolamine Phospholipase A₂ in Brain During Ischemia

1982 • 183 citations

Protective effect of α-tocopherol on ischemic neuronal damage in the gerbil hippocampus

1990 • 180 citations

Effects of the 21-aminosteroid U74006F on posttraumatic spinal cord ischemia in cats

1988 • 176 citations

Allopurinol and dimethylthiourea reduce brain infarction following middle cerebral artery occlusion in rats.

1989 • 162 citations

Dopamine depletion protects striatal neurons from ischemia-induced cell death

1988 • 141 citations

Brain anoxia releases striatal dopamine in rats

1986 • 93 citations

LY178002 reduces rat brain damage after transient global forebrain ischemia.

1991 • 76 citations

Platelet activating factor receptor blockade enhances recovery after multifocal brain ischemia

1987 • 64 citations

Amelioration of brain damage after focal ischemia in the rat by a novel inhibitor of lipid peroxidation

1991 • 28 citations

The Role of Platelet‐Activating Factor in Cerebral Ischemia and Related Disorders

1989 • 27 citations

Involvement of a serine esterase in oxidant‐mediated activation of phospholipase A₂ in pulmonary endothelium

1991 • 18 citations