Regulation of binding proteins for insulin-like growth factors (IGF) in humans. Increased expression of IGF binding protein 2 during IGF I treatment of healthy adults and in patients with extrapancreatic tumor hypoglycemia.

Analysis of serum insulin-like growth factor binding proteins using Western blotting: Use of the method for titration of the binding proteins and competitive binding studies

1986 • 1,158 citations

An insulin-like growth factor (IGF) binding protein enhances the biologic response to IGF-I.

1987 • 682 citations

Radioimmunological determination of insulinlike growth factors I and II in normal subjects and in patients with growth disorders and extrapancreatic tumor hypoglycemia.

1981 • 595 citations

Insulin-like growth factors I and II in healthy man.

1989 • 513 citations

Growth hormone-dependent insulin-like growth factor (IGF) binding protein both inhibits and potentiates IGF-I-stimulated DNA synthesis in human skin fibroblasts

1988 • 488 citations

Synthesis and Secretion of Insulin-Like Growth Factor and Its Binding Protein by the Perfused Rat Liver: Dependence on Growth Hormone Status^*

1983 • 447 citations

Recombinant human insulin-like growth factor I stimulates growth and has distinct effects on organ size in hypophysectomized rats.

1988 • 424 citations

Cloning and Expression of the Growth Hormone-Dependent Insulin-Like Growth Factor-Binding Protein

1988 • 367 citations

Synthesis and Secretion of Insulin-like Growth Factor II by a Leiomyosarcoma with Associated Hypoglycemia

1988 • 346 citations

Effects of recombinant insulin-like growth factor I on insulin secretion and renal function in normal human subjects.

1989 • 320 citations

High molecular weight insulin-like growth factor binding protein complex

1989 • 315 citations

Structure of the Mr 140,000 growth hormone-dependent insulin-like growth factor binding protein complex: determination by reconstitution and affinity-labeling.

1989 • 308 citations

Acute metabolic effects and half-lives of intravenously administered insulinlike growth factors I and II in normal and hypophysectomized rats.

1986 • 306 citations

Nucleotide Sequence and Expression of a cDNA Clone Encoding a Fetal Rat Binding Protein for Insulin-like Growth Factors

1989 • 263 citations

Binding of nonsuppressible insulinlike activity to human serum

1975 • 253 citations

Cloning, sequence analysis and expression of a cDNA encoding a novel insulin-like growth factor binding protein (IGFBP-2).

1989 • 240 citations

Recombinant human insulin-like growth factor I induces its own specific carrier protein in hypophysectomized and diabetic rats.

1989 • 221 citations

Insulin-Like Growth Factor (IGF) and IGF-Binding Proteins: Comparison of Human Serum and Lymph*

1988 • 216 citations

Inhibition of biological activity of multiplication-stimulating activity by binding to its carrier protein.

1980 • 212 citations

The Somatomedin C Binding Protein: Evidence for a Heterologous Subunit Structure*

1980 • 193 citations

Molecular Forms of Serum Insulin-Like Growth Factor (IGF)-Binding Proteins in Man: Relationships with Growth Hormone and IGFs and Physiological Significance*

1989 • 190 citations

Heterogeneity of insulin‐like growth factor binding proteins and relationships between structure and affinity

1987 • 173 citations

THE SERUM HALF-LIFE OF SOMATOMEDIN ACTIVITY: EVIDENCE FOR GROWTH HORMONE DEPENDENCE

1976 • 159 citations

A Low Molecular Weight Insulin-Like Growth Factor Binding Protein from Rat: cDNA Cloning and Tissue Distribution of its Messenger RNA

1989 • 158 citations

Significance of abnormal serum binding of insulin-like growth factor II in the development of hypoglycemia in patients with non-islet-cell tumors.

1989 • 139 citations

Plasma Somatomedin-Binding Proteins in Hypopituitarism: Changes during Growth Hormone Therapy*

1981 • 123 citations

Serum levels of insulin-like growth factor (IGF) and its carrier protein in various metabolic disorders

1980 • 122 citations

Identification of an insulin‐like growth factor‐binding protein in human cerebrospinal fluid with a selective affinity for IGF‐II

1986 • 118 citations

Affinity-labeled plasma somatomedin-C/insulinlike growth factor I binding proteins. Evidence of growth hormone dependence and subunit structure.

1985 • 113 citations

The riddle of tumor hypoglycemia

1966 • 110 citations

Release of insulin-like growth factor carrier proteins by osteoblasts: Stimulation by estradiol and growth hormone

1989 • 110 citations

The riddle of tumour hypoglycaemia revisited

1980 • 108 citations

Purification and amino-terminal sequence of an insulin-like growth factor-binding protein secreted by rat liver BRL-3A cells.

1986 • 108 citations

NSILA-carrier protein abolishes the action of nonsuppressible insulin-like activity (NSILA-S) on perfused rat heart

1978 • 94 citations

Is Extrapancreatic Tumor Hypoglycemia Associated with Elevated Levels of Insulin-Like Growth Factor II?*

1982 • 77 citations

Heterogeneity of insulin‐like growth factor binding proteins between structure and affinity

1987 • 75 citations

Increased Insulin-Like Growth Factor II Production and Consequent Suppression of Growth Hormone Secretion: A Dual Mechanism for Tumor-Induced Hypoglycemia

1989 • 74 citations

Growth hormone-dependent insulin-like growth factor (IGF) binding protein from human plasma differs from other human igf binding proteins

1986 • 67 citations

ANTIBODY AGAINST ACID-STABLE INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN DETECTS 150,000 MOL WT GROWTH HORMONE-DEPENDENT COMPLEX IN HUMAN PLASMA

1985 • 61 citations

Production of carrier proteins for insulin‐like growth factors (IGFs) by rat osteoblastic cells Regulation by IGF I and cortisol

1989 • 56 citations

Insulin Secretion in Acromegaly

1970 • 51 citations

Regulation of hepatic expression of IGF I and fetal IGF binding protein mRNA in streptozotocin‐diabetic rats

1989 • 46 citations

Syndrome of familial dwarfism and high plasma immunoreactive growth hormone.

1974 • 31 citations

An insulin-like growth factor (IGF) binding protein enhances the biologic response to IGF-I.

1987 • 31 citations

On the Nomenclature of the IGF Binding Proteins

1989 • 22 citations

Affinity-labeled plasma somatomedin-C/insulinlike growth factor I binding proteins. Evidence of growth hormone dependence and subunit structure.

1985 • 6 citations

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