Arachidonic acid mobilization in platelets: The possible role of protein kinase C and G-proteins

Protein kinase C phosphorylates the inhibitory guanine‐nucleotide‐binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclase

1985 • 736 citations

Inhibition of phospholipase A2 by "lipocortins" and calpactins. An effect of binding to substrate phospholipids.

1987 • 534 citations

Phospholipase A2 and phospholipase C are activated by distinct GTP-binding proteins in response to alpha 1-adrenergic stimulation in FRTL5 thyroid cells.

1986 • 424 citations

Two human 35 kd inhibitors of phospholipase A2 are related to substrates of pp60v-src and of the epidermal growth factor receptor/kinase

1986 • 421 citations

Normal p21N-ras couples bombesin and other growth factor receptors to inositol phosphate production

1986 • 406 citations

Protein kinase C phosphorylates human platelet inositol trisphosphate 5′-phosphomonoesterase, increasing the phosphatase activity

1986 • 354 citations

Characterization of 1,2-diacylglycerol hydrolysis in human platelets. Demonstration of an arachidonoyl-monoacylglycerol intermediate.

1983 • 312 citations

Epidermal growth factor-dependent phosphorylation of lipocortin

1986 • 303 citations

Mass changes in myoinositol trisphosphate in human platelets stimulated by thrombin. Inhibitory effects of phorbol ester.

1985 • 292 citations

Liberation of [3H]arachidonic acid and changes in cytosolic free calcium in fura-2-loaded human platelets stimulated by ionomycin and collagen

1986 • 292 citations

Regulation of the phosphoinositide hydrolysis pathway in thrombin-stimulated platelets by a pertussis toxin-sensitive guanine nucleotide-binding protein. Evaluation of its contribution to platelet activation and comparisons with the adenylate cyclase inhibitory protein, Gi.

1986 • 235 citations

Platelet activation—a role for a 40K anti-phospholipase A2 protein indistinguishable from lipocortin

1986 • 233 citations

Receptor-Induced Diacylglycerol Formation in Permeabilized Platelets; Possible Role for a Gtp-Binding Protein

1984 • 206 citations

Purification and characterization of the 47,000-dalton protein phosphorylated during degranulation of human platelets.

1983 • 179 citations

Phorbol myristate acetate inhibits thrombin-stimulated Ca2+ mobilization and phosphatidylinositol 4,5-bisphosphate hydrolysis in human platelets.

1985 • 179 citations

Activation of sodium–proton exchange is a prerequisite for Ca2+ mobilization in human platelets

1987 • 176 citations

Tumour‐promoting phorbol esters inhibit agonist‐induced phosphatidate formation and Ca²⁺ flux in human platelets

1985 • 173 citations

Phorbol esters and oleoyl acetoyl glycerol enhance release of arachidonic acid in platelets stimulated by Ca2+ ionophore A23187.

1985 • 163 citations

Activation of human platelet phospholipase C by ionophore A23187 is totally dependent upon cyclo-oxygenase products and ADP

1984 • 162 citations

Long-chain unsaturated diacylglycerols cause A perturbation in the structure of phospholipid bilayers rendering them susceptible to phospholipase attack

1984 • 159 citations

Regulation of intracellular pH in human platelets. Effects of thrombin, A23187, and ionomycin and evidence for activation of Na+/H+ exchange and its inhibition by amiloride analogs.

1986 • 153 citations

Phosphorylation at a tyrosine residue of lipomodulin in mitogen-stimulated murine thymocytes.

1984 • 153 citations

Identification and purification of sheep platelet phospholipase A2 isoforms. Activation by physiologic concentrations of calcium ion.

1986 • 147 citations

Inhibitors of Na+/H+ exchange block stimulus-provoked arachidonic acid release in human platelets. Selective effects on platelet activation by epinephrine, ADP, and lower concentrations of thrombin.

1985 • 144 citations

Arachidonic Acid Release and Catecholamine Secretion from Digitonin‐Treated Chromaffin Cells: Effects of Micromolar Calcium, Phorbol Ester, and Protein Alkylating Agents

1985 • 97 citations

Measurement of arachidonic acid liberation in thrombin-stimulated human platelets. Use of agents that inhibit both the cyclooxygenase and lipoxygenase enzymes

1985 • 88 citations

Phosphorylation of lipocortins invitro by protein kinase C

1986 • 75 citations

Synergistic stimulation of thromboxane biosynthesis by calcium ionophore and phorbol ester or thrombin in human platelets

1985 • 70 citations

Phorbol 12-myristate, 13-acetate potentiates the action of the calcium ionophore in stimulating arachidonic acid release and production of phosphatidic acid in rabbit neutrophils

1985 • 69 citations

Stimulated platelets release equivalent amounts of arachidonate from phosphatidylcholine, phosphatidylethanolamine, and inositides.

1988 • 66 citations

Modulation by phorbol myristate acetate of arachidonic acid release and leukotriene synthesis by human polymorphonuclear leukocytes stimulated with A23187

1986 • 61 citations

Effects of thrombin, phorbol myristate acetate and prostaglandin D₂ on 40–41 kDa protein that is ADP ribosylated by pertussis toxin in platelets

1986 • 52 citations

Thrombin and C-kinase activators potentiate calcium-stimulated arachidonic acid release in human platelets

1987 • 45 citations

Point-mutated P21 couples a muscarinic receptor to calcium channels and polyphosphoinositide hydrolysis

1986 • 34 citations

Stimulus‐response coupling in a cell‐free platelet membrane system

1987 • 30 citations

Phosphorylation of the 47 KDa protein in gamma-thrombin-stimulated human platelets does not activate phospholipase A2: Evidence against lipocortin

1986 • 24 citations

A phorbol ester and 1-oleoyl-2-acetylglycerol induce NA+/H+ exchange in human platelets

1986 • 22 citations

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