Regulation of intracellular pH in human platelets. Effects of thrombin, A23187, and ionomycin and evidence for activation of Na+/H+ exchange and its inhibition by amiloride analogs.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator.

1982 • 2,255 citations

Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ

1979 • 2,166 citations

Cytoplasmic pH and free Mg2+ in lymphocytes.

1982 • 1,047 citations

Modifier role of internal H+ in activating the Na+–H+ exchanger in renal microvillus membrane vesicles

1982 • 681 citations

A specific mutation abolishing Na+/H+ antiport activity in hamster fibroblasts precludes growth at neutral and acidic pH.

1984 • 544 citations

Intracellular pH: Its Measurement, Regulation, and Utilization in Cellular Functions.

1982 • 544 citations

The plasma membrane sodium-hydrogen exchanger and its role in physiological and pathophysiological processes.

1985 • 506 citations

Phorbol ester and diacylglycerol mimic growth factors in raising cytoplasmic pH

1984 • 447 citations

The respiratory burst of phagocytic cells is associated with a rise in vacuolar pH

1981 • 429 citations

Pyrazine Diuretics. II. N-Amidino-3-amino-5-substituted 6-Halopyrazinecarboxamides

1967 • 323 citations

Pharmacology and Toxicology of the Monovalent Carboxylic Ionophores

1982 • 311 citations

The cytoplasmic concentration of free calcium in platelets is controlled by stimulators of cyclic AMP production (PGD2, PGE1, forskolin)

1983 • 217 citations

Structure-activity relationships of amiloride and certain of its analogues in relation to the blockade of the Na+/H+ exchange system.

1984 • 204 citations

Amiloride inhibits phorbol ester-stimulated Na+/H+ exchange and protein kinase C. An amiloride analog selectively inhibits Na+/H+ exchange.

1985 • 203 citations

Phorbol myristate acetate inhibits thrombin-stimulated Ca2+ mobilization and phosphatidylinositol 4,5-bisphosphate hydrolysis in human platelets.

1985 • 179 citations

Pertussis toxin inhibits fMet-Leu-Phe- but not phorbol ester-stimulated changes in rabbit neutrophils: role of G proteins in excitation response coupling.

1985 • 175 citations

Amiloride Directly Inhibits the Na,K-ATPase Activity of Rabbit Kidney Proximal Tubules

1983 • 172 citations

Intracellular pH modulates the generation of superoxide radicals by human neutrophils.

1985 • 156 citations

Changes in Cytoplasmic pH and in Membrane Potential in Thrombin-Stimulated Human Platelets

1981 • 152 citations

Inhibitors of Na+/H+ exchange block stimulus-provoked arachidonic acid release in human platelets. Selective effects on platelet activation by epinephrine, ADP, and lower concentrations of thrombin.

1985 • 144 citations

Amiloride-sensitive Na+/H+ exchange in human neutrophils: Mechanism of activation by chemotactic factors

1984 • 111 citations

Specific modulation of the intracellular pH of rabbit neutrophils by chemotactic factors

1980 • 106 citations

High tyrosine kinase activity in normal nonproliferating cells

1983 • 103 citations

Mitogens and melittin stimulate an increase in intracellular free calcium concentration in human fibroblasts

1984 • 99 citations

Amiloride blocks cell-free protein synthesis at levels attained inside cultured rat hepatocytes

1982 • 77 citations

Amiloride-sensitive Na+-H+ exchange in platelets and leukocytes: detection by electronic cell sizing

1984 • 73 citations

Ionomycin can elevate intraplatelet Ca2+ and activate phospholipase a without activating phospholipase C

1984 • 72 citations

Diuretics: Chemistry, Pharmacology, and Medicine

1984 • 56 citations

Platelet Shape Change and Cytoskeletal Assembly: Effects of pH and Monovalent Cation lonophores

1983 • 49 citations

Thrombin stimulates Na⁺‐H⁺ exchange across the human platelet plasma membrane

1984 • 48 citations

Demonstration of a Na+/H+ exchange activity in purified canine cardiac sarcolemmal vesicles.

1985 • 38 citations

The effects of alterations of transmembrane Na+ and K+ gradients by ionophores (nigericin, monensin) on serotonin transport in human blood platelets

1977 • 38 citations

Evidence for A role of Na+H+ exchange in platelets activated with calcium-ionophore A 23187

1984 • 35 citations

Measurement of the intracellular pH of blood platelets using a photolabel fluorescent probe

1982 • 5 citations