Interleukin-12: Potential Clinical Applications in the Treatment and Prevention of Infectious Diseases

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes.

1989 • 1,989 citations

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.

1993 • 1,704 citations

Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes

1994 • 1,066 citations

Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers.

1991 • 976 citations

Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells.

1991 • 861 citations

Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts.

1993 • 837 citations

Recombinant interleukin 12 cures mice infected with Leishmania major.

1993 • 776 citations

Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response.

1993 • 738 citations

Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii.

1994 • 729 citations

The Th1–Th2 hypothesis of HIV infection: new insights

1994 • 708 citations

The Adjuvant Effect of Interleukin-12 in a Vaccine Against Leishmania major

1994 • 687 citations

Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor.

1991 • 593 citations

IL-12: Initiation Cytokine for Cell-Mediated Immunity

1993 • 583 citations

Interleukin‐12 is required for interferon‐γ production and lethality in lipopolysaccharide‐induced shock in mice

1995 • 491 citations

Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor).

1991 • 471 citations

Impaired interleukin 12 production in human immunodeficiency virus-infected patients.

1994 • 435 citations

Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice.

1995 • 428 citations

Restoration of HIV-Specific Cell-Mediated Immune Responses by Interleukin-12 in Vitro

1993 • 397 citations

Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-γ in vivo

1994 • 373 citations

B7 and interleukin 12 cooperate for proliferation and interferon gamma production by mouse T helper clones that are unresponsive to B7 costimulation.

1994 • 367 citations

Regulation of human cytolytic lymphocyte responses by interleukin-12

1992 • 331 citations

Interleukin‐12 profoundly up‐regulates the synthesis of antigen‐specific complement‐fixing IgG2a, IgG2b and IgG3 antibody subclasses in vivo

1995 • 331 citations

IL-12 increases resistance of BALB/c mice to Mycobacterium tuberculosis infection.

1995 • 325 citations

Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130.

1994 • 309 citations

The role of interleukin-12 in acquired immunity to Mycobacterium tuberculosis infection.

1995 • 308 citations

IL-12 receptor. II. Distribution and regulation of receptor expression.

1992 • 298 citations

Interleukin 12, interferon gamma, and tumor necrosis factor alpha are the key cytokines of the generalized Shwartzman reaction.

1994 • 235 citations

Effects of IL-12 on the response and susceptibility to experimental viral infections.

1994 • 233 citations

Interleukin 12 at the site of disease in tuberculosis.

1994 • 218 citations

Mechanism of interleukin 12-mediated toxicities during experimental viral infections: role of tumor necrosis factor and glucocorticoids.

1995 • 215 citations

IL-12 prevents mortality in mice infected with Histoplasma capsulatum through induction of IFN-gamma.

1995 • 214 citations

Effects of IL-12 on the generation of cytotoxic activity in human CD8+ T lymphocytes.

1993 • 214 citations

Type 1/type 2 cytokine modulation of T-cell programmed cell death as a model for human immunodeficiency virus pathogenesis.

1994 • 206 citations

Administration of interleukin 12 in combination with type II collagen induces severe arthritis in DBA/1 mice.

1995 • 198 citations

Natural killer (NK) cell stimulatory factor increases the cytotoxic activity of NK cells from both healthy donors and human immunodeficiency virus-infected patients.

1992 • 198 citations

Important advances in oncology 1996

1997 • 184 citations

Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and Pentostam.

1995 • 179 citations

IL-12 is both required and prognostic in vivo for T helper type 1 differentiation in murine candidiasis.

1994 • 140 citations

Cytokine treatment of central nervous system infection: efficacy of interleukin-12 alone and synergy with conventional antifungal therapy in experimental cryptococcosis

1994 • 133 citations

Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5

1992 • 130 citations

Interleukin-12 gene expression after viral infection in the mouse

1995 • 119 citations

In vivo treatment with interleukin 12 protects mice from immune abnormalities observed during murine acquired immunodeficiency syndrome (MAIDS).

1994 • 106 citations

Role of IL-12 in human B lymphocyte proliferation and differentiation.

1995 • 89 citations

Biologic effects of recombinant human interleukin-12 in squirrel monkeys (Sciureus saimiri).

1994 • 82 citations

Effects of the Th1 and Th2 stimulatory cytokines interleukin-12 and interleukin-4 on human immunodeficiency virus replication

1995 • 65 citations

Interleukin 12 suppresses autoantibody production by reversing helper T-cell phenotype in hepatitis B e antigen transgenic mice.

1995 • 60 citations

Interleukin-12: a cytokine with therapeutic potential in oncology and infectious diseases.

1994 • 59 citations

Synergistic effects of interleukin 4 and interleukin 12 on NK cell proliferation

1993 • 54 citations

Interleukin-12: potential role in cancer therapy.

1995 • 38 citations

Multiple Effects on Peripheral Hematology Following Administration of Recombinant Human Interleukin 12 to Nonhuman Primates

1994 • 37 citations

IL12 receptors and receptor antagonists

1995 • 27 citations

Pharmacokinetics and pharmacodynamics of recombinant human interleukin-12 in male rhesus monkeys.

1995 • 20 citations