The Puf3 protein is a transcript-specific regulator of mRNA degradation in yeast

A turnover pathway for both stable and unstable mRNAs in yeast: evidence for a requirement for deadenylation.

1993 • 660 citations

INTERRELATIONSHIPS OF THE PATHWAYS OF mRNA DECAY AND TRANSLATION IN EUKARYOTIC CELLS

1996 • 653 citations

The 3' to 5' degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SKI2 DEVH box protein and 3' to 5' exonucleases of the exosome complex

1998 • 632 citations

Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay.

1991 • 546 citations

Maternal Pumilio acts together with Nanos in germline development in Drosophila embryos

1999 • 527 citations

Deadenylation of the unstable mRNA encoded by the yeast MFA2 gene leads to decapping followed by 5'-->3' digestion of the transcript.

1994 • 511 citations

CONTROL OF TRANSLATION INITIATION IN ANIMALS

1998 • 507 citations

A conserved RNA-binding protein that regulates sexual fates in the C. elegans hermaphrodite germ line

1997 • 504 citations

Characterization of , a Yeast Gene Involved in Copper Metabolism and Assembly of Cytochrome Oxidase

1996 • 483 citations

Nanos and Pumilio have critical roles in the development and function of Drosophila germline stem cells

1998 • 473 citations

Binding of pumilio to maternal hunchback mRNA is required for posterior patterning in drosophila embryos

1995 • 419 citations

Identification and comparison of stable and unstable mRNAs in Saccharomyces cerevisiae.

1990 • 409 citations

Premature translational termination triggers mRNA decapping

1994 • 399 citations

Yeast cells lacking 5'-->3' exoribonuclease 1 contain mRNA species that are poly(A) deficient and partially lack the 5' cap structure.

1993 • 378 citations

Redistribution of Silencing Proteins from Telomeres to the Nucleolus Is Associated with Extension of Life Span in S. cerevisiae

1997 • 371 citations

Turnover Mechanisms of the Stable Yeast PGK1 mRNA

1995 • 341 citations

The Pumilio protein binds RNA through a conserved domain that defines a new class of RNA-binding proteins.

1997 • 329 citations

Recruitment of Nanos to hunchback mRNA by Pumilio

1999 • 328 citations

Mammalian Glucocorticoid Receptor Derivatives Enhance Transcription in Yeast

1988 • 315 citations

mRNA Decay Mediated by Two Distinct AU-Rich Elements from c-fos and Granulocyte-Macrophage Colony-Stimulating Factor Transcripts: Different Deadenylation Kinetics and Uncoupling from Translation

1995 • 276 citations

NANOS-3 and FBF proteins physically interact to control the sperm–oocyte switch in Caenorhabditis elegans

1999 • 268 citations

The Pumilio RNA-Binding Domain Is Also a Translational Regulator

1998 • 243 citations

Diversity of cytoplasmic functions for the 3′ untranslated region of eukaryotic transcripts

1995 • 241 citations

Mutations in Translation Initiation Factors Lead to Increased Rates of Deadenylation and Decapping of mRNAs in Saccharomyces cerevisiae

1999 • 240 citations

Purification, Characterization, and Localization of Yeast Cox17p, a Mitochondrial Copper Shuttle

1997 • 237 citations

Mutations affecting stability and deadenylation of the yeast MFA2 transcript.

1992 • 228 citations

Nanos and pumilio establish embryonic polarity in Drosophila by promoting posterior deadenylation of hunchback mRNA

1997 • 228 citations

Pumilio is essential for function but not for distribution of the Drosophila abdominal determinant Nanos.

1992 • 203 citations

A small segment of the MAT alpha 1 transcript promotes mRNA decay in Saccharomyces cerevisiae: a stimulatory role for rare codons.

1993 • 192 citations

Yeast Cells Lacking 5'→3' Exoribonuclease 1 Contain mRNA Species That are Poly(A) Deficient and Partially Lack the 5' Cap Structure

1993 • 190 citations

mRNA Decapping in Yeast Requires Dissociation of the Cap Binding Protein, Eukaryotic Translation Initiation Factor 4E

2000 • 184 citations

Mutations in trans-Acting Factors Affecting mRNA Decapping in Saccharomyces cerevisiae

1996 • 168 citations

Mechanisms And Control Of mRNA Decapping in Saccharomyces cerevisiae

2000 • 150 citations

The majority of yeast UPF1 co-localizes with polyribosomes in the cytoplasm.

1995 • 132 citations

Identification and Comparison of Stable and Unstable mRNAs in Saccharomyces cerevisiae

1990 • 125 citations

RNA-protein interactions in the control of stability and localization of messenger RNA (review).

2000 • 118 citations

The Drosophila pumilio Gene Encodes Two Functional Protein Isoforms That Play Multiple Roles in Germline Development, Gonadogenesis,Oogenesis and Embryogenesis

1999 • 110 citations

The most abundant small cytoplasmic RNA of Saccharomyces cerevisiae has an important function required for normal cell growth.

1989 • 105 citations

The PUMILIO−RNA Interaction: A Single RNA-Binding Domain Monomer Recognizes a Bipartite Target Sequence

1998 • 94 citations

The cis acting sequences responsible for the differential decay of the unstable MFA2 and stable PGK1 transcripts in yeast include the context of the translational start codon

1999 • 92 citations

Molecular analysis ofPOP2gene, a gene required for glucose-derepression of gene expression inSaccharomyces cerevisiae

1992 • 64 citations

A Small Segment of the MATα1 Transcript Promotes mRNA Decay in Saccharomyces cerevisiae: a Stimulatory Role for Rare Codons

1993 • 63 citations

Saccharomyces cerevisiae Mpt5p Interacts with Sst2p and Plays Roles in Pheromone Sensitivity and Recovery from Pheromone Arrest

1997 • 49 citations

Microtubule stability in budding yeast: characterization and dosage suppression of a benomyl-dependent tubulin mutant.

1995 • 46 citations

A new yeast gene, HTR1, required for growth at high temperature, is needed for recovery from mating pheromone-induced G1 arrest

1994 • 37 citations

Glucose-regulated Turnover of mRNA and the Influence of Poly(A) Tail Length on Half-life

2000 • 26 citations

Functional analysis of three adjacent open reading frames from the right arm of yeast chromosome XVI

1998 • 6 citations