Advantages of dietary, exercise-related, and therapeutic interventions to prevent and treat sarcopenia in adult patients: an update

Epidemiology of Sarcopenia among the Elderly in New Mexico

1998 • 3,805 citations

Physical Activity and Public Health in Older Adults

2007 • 2,990 citations

Low Relative Skeletal Muscle Mass (Sarcopenia) in Older Persons Is Associated with Functional Impairment and Physical Disability

2002 • 2,946 citations

Sarcopenia: Origins and Clinical Relevance

1997 • 2,061 citations

Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia

2003 • 1,818 citations

Invited Review: Aging and sarcopenia

2003 • 1,757 citations

Age Trends in the Level of Serum Testosterone and Other Hormones in Middle-Aged Men: Longitudinal Results from the Massachusetts Male Aging Study

2002 • 1,691 citations

Research Agenda for Frailty in Older Adults: Toward a Better Understanding of Physiology and Etiology: Summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults

2006 • 1,500 citations

The Healthcare Costs of Sarcopenia in the United States

2003 • 1,406 citations

Skeletal Muscle Cutpoints Associated with Elevated Physical Disability Risk in Older Men and Women

2004 • 1,152 citations

A Systematic Screening of Total Antioxidants in Dietary Plants

2002 • 1,135 citations

Progressive resistance strength training for improving physical function in older adults

2009 • 1,037 citations

Body Composition in Healthy Aging

2000 • 1,006 citations

Sarcopenia: Its assessment, etiology, pathogenesis, consequences and future perspectives

2008 • 980 citations

Myostatin, a Negative Regulator of Muscle Growth, Functions by Inhibiting Myoblast Proliferation

2000 • 972 citations

Sarcopenia: Alternative Definitions and Associations with Lower Extremity Function

2003 • 939 citations

Sarcopenic Obesity Predicts Instrumental Activities of Daily Living Disability in the Elderly

2004 • 888 citations

Myostatin Inhibits Myoblast Differentiation by Down-regulating MyoD Expression

2002 • 869 citations

Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men

1997 • 822 citations

Aging of the human neuromuscular system

2001 • 798 citations

Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults

2003 • 797 citations

Dietary protein recommendations and the prevention of sarcopenia

2008 • 784 citations

Longitudinal changes in body composition in older men and women: role of body weight change and physical activity

2002 • 783 citations

Alternative Definitions of Sarcopenia, Lower Extremity Performance, and Functional Impairment with Aging in Older Men and Women

2007 • 765 citations

Myostatin negatively regulates satellite cell activation and self-renewal

2003 • 748 citations

Sarcopenia: etiology, clinical consequences, intervention, and assessment

2009 • 705 citations

Association of Muscle Power With Functional Status in Community-Dwelling Elderly Women

2000 • 648 citations

Understanding sarcopenia as a geriatric syndrome

2009 • 568 citations

Muscle strength, power and adaptations to resistance training in older people

2003 • 541 citations

Systematic Review of Progressive Resistance Strength Training in Older Adults

2004 • 532 citations

Effectiveness and economic evaluation of a nurse delivered home exercise programme to prevent falls. 1: Randomised controlled trial

2001 • 532 citations

The case against ergocalciferol (vitamin D2) as a vitamin supplement1,2

2006 • 519 citations

Review Article: Sarcopenia: Causes, Consequences, and Preventions

2003 • 513 citations

Vitamin D fortification in the United States and Canada: current status and data needs

2004 • 507 citations

Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids

2005 • 490 citations

Vitamin D: the underappreciated D-lightful hormone that is important for skeletal and cellular health

2002 • 483 citations

A Comparison of Leg Power and Leg Strength Within the InCHIANTI Study: Which Influences Mobility More?

2003 • 474 citations

Weight stability masks sarcopenia in elderly men and women

2000 • 460 citations

Difficulties with physical function associated with obesity, sarcopenia, and sarcopenic-obesity in community-dwelling elderly women: the EPIDOS (EPIDemiologie de l’OSteoporose) Study

2009 • 451 citations

Growth Hormone and Sex Steroid Administration in Healthy Aged Women and Men

2002 • 444 citations

High‐Velocity Resistance Training Increases Skeletal Muscle Peak Power in Older Women

2002 • 439 citations

Prevalence of Sarcopenia Estimated Using a Bioelectrical Impedance Analysis Prediction Equation in Community‐Dwelling Elderly People in Taiwan

2008 • 434 citations

Regulation of Amino Acid and Glucose Transporters in Endothelial and Smooth Muscle Cells

2003 • 419 citations

Decreased Food Intake With Aging

2001 • 419 citations

Sarcopenia and its implications for the elderly

2000 • 418 citations

The contribution of reactive oxygen species to sarcopenia and muscle ageing

2003 • 408 citations

Once‐Weekly Resistance Exercise Improves Muscle Strength and Neuromuscular Performance in Older Adults

1999 • 403 citations

Physical disability and muscular strength in relation to obesity and different body composition indexes in a sample of healthy elderly women

2004 • 389 citations

Anthropometric assessment of 10-y changes in body composition in the elderly

2004 • 386 citations

Effect of Strength and Power Training on Physical Function in Community-Dwelling Older Adults

2003 • 386 citations

Apoptosis in skeletal muscle with aging

2002 • 382 citations

Age Trends in the Level of Serum Testosterone and Other Hormones in Middle-Aged Men: Longitudinal Results from the Massachusetts Male Aging Study

2002 • 378 citations

Sarcopenia: Diagnosis and treatment

2008 • 373 citations

Skeletal muscle protein anabolic response to resistance exercise and essential amino acids is delayed with aging

2008 • 373 citations

The vitamin D questions: How much do you need and how should you get it?

2006 • 372 citations

Prevalence of sarcopenia and sarcopenic obesity in Korean adults: the Korean sarcopenic obesity study

2009 • 363 citations

Effects of antioxidant supplementation on the aging process.

2007 • 334 citations

Is grip strength associated with health-related quality of life? Findings from the Hertfordshire Cohort Study

2006 • 333 citations

A Moderate Serving of High-Quality Protein Maximally Stimulates Skeletal Muscle Protein Synthesis in Young and Elderly Subjects

2009 • 331 citations

Vitamin D and skeletal muscle tissue and function

2008 • 329 citations

Relation between use of angiotensin-converting enzyme inhibitors and muscle strength and physical function in older women: an observational study

2002 • 326 citations

Muscle Power of the Ankle Flexors Predicts Functional Performance in Community‐Dwelling Older Women

2001 • 325 citations

Exercise‐induced Modulation of Antioxidant Defense

2002 • 320 citations

Associations of Body Composition with Physical Performance and Self-reported Functional Limitation in Elderly Men and Women

2002 • 316 citations

Clinical pharmacokinetics of angiotensin II (AT1) receptor blockers in hypertension

2000 • 308 citations

Practical implementation of an exercise-based falls prevention programme

2001 • 307 citations

Effects of skin thickness, age, body fat, and sunlight on serum 25-hydroxyvitamin D

1993 • 305 citations

Skeletal Muscle Mass and Muscle Strength in Relation to Lower‐Extremity Performance in Older Men and Women

2000 • 304 citations

Efficacy of Progressive Resistance Training on Balance Performance in Older Adults

2008 • 300 citations

Effect of high versus low-velocity resistance training on muscular fitness and functional performance in older men

2006 • 295 citations

Resistance exercise acutely increases MHC and mixed muscle protein synthesis rates in 78–84 and 23–32 yr olds

2000 • 286 citations

Sarcopenia: Effects on Body Composition and Function

2003 • 278 citations

Anorexia, sarcopenia, and aging

2001 • 275 citations

Age Trajectories of Grip Strength: Cross-Sectional and Longitudinal Data Among 8,342 Danes Aged 46 to 102

2006 • 272 citations

Sarcopenic-obesity and cardiovascular disease risk in the elderly

2009 • 271 citations

Hand grip strength and incident ADL disability in elderly Mexican Americans over a seven-year period

2004 • 264 citations

Differential adaptations to eccentric versus conventional resistance training in older humans

2009 • 261 citations

Creatine Supplementation Enhances Isometric Strength and Body Composition Improvements Following Strength Exercise Training in Older Adults

2003 • 254 citations

Strength Versus Muscle Power-Specific Resistance Training in Community-Dwelling Older Adults

2008 • 253 citations

Is Stair Climb Power a Clinically Relevant Measure of Leg Power Impairments in At-Risk Older Adults?

2007 • 251 citations

Explosive heavy‐resistance training in old and very old adults: changes in rapid muscle force, strength and power

2008 • 238 citations

Effect of perindopril on physical function in elderly people with functional impairment: a randomized controlled trial

2007 • 237 citations

Strength, power output and symmetry of leg muscles: effect of age and history of falling

2006 • 236 citations

Lower extremity muscle mass predicts functional performance in mobility-limited elders

2008 • 233 citations

The effect of obesity combined with low muscle strength on decline in mobility in older persons: results from the InCHIANTI Study

2009 • 230 citations

Nutritional Supplements with Oral Amino Acid Mixtures Increases Whole-Body Lean Mass and Insulin Sensitivity in Elderly Subjects with Sarcopenia

2008 • 226 citations

Relationships Among Impairments in Lower-Extremity Strength and Power, Functional Limitations, and Disability in Older Adults

2007 • 225 citations

Sarcopenia: a major modifiable cause of frailty in the elderly.

2000 • 224 citations

Invited Review: Aging and energy balance

2003 • 216 citations

Dietary implications on mechanisms of sarcopenia: roles of protein, amino acids and antioxidants

2009 • 215 citations

Creatine supplementation combined with resistance training in older men

2001 • 213 citations

A 3-year longitudinal study on body composition changes in the elderly: Role of physical exercise

2005 • 210 citations

Body composition changes in stable-weight elderly subjects: The effect of sex

2003 • 197 citations

Improved Physical Performance in Older Adults Undertaking a Short-Term Programme of High-Velocity Resistance Training

2005 • 195 citations

Food Contents and Biological Activity of 25-Hydroxyvitamin D: A Vitamin D Metabolite to Be Reckoned With?

2003 • 191 citations

Testosterone and Growth Hormone Improve Body Composition and Muscle Performance in Older Men

2009 • 184 citations

Kinetics of Human Aging: I. Rates of Senescence Between Ages 30 and 70 Years in Healthy People

2001 • 184 citations

Skeletal muscle oxidative capacity in young and older women and men

2000 • 179 citations

Longitudinal changes in adult fat-free mass: influence of body weight

1999 • 179 citations

Recurrent and Injurious Falls in the Year Following Hip Fracture: A Prospective Study of Incidence and Risk Factors From the Sarcopenia and Hip Fracture Study

2009 • 177 citations

Genetic Variation in the Renin–Angiotensin System and Abdominal Adiposity in Men: The Olivetti Prospective Heart Study

2003 • 176 citations

Functional Status and Self‐Rated Health in 2,262 Nonagenarians: The Danish 1905 Cohort Survey

2001 • 175 citations

Photobiology of Vitamin D

2010 • 172 citations

Dynapenic-Obesity and Physical Function in Older Adults

2009 • 169 citations

Resistance training, sarcopenia, and the mitochondrial theory of aging

2008 • 163 citations

Serum 25-hydroxyvitamin D and functional outcomes in the elderly

2008 • 154 citations

Creatine supplementation improves muscular performance in older men

2002 • 147 citations

Lower extremity power training in elderly subjects with mobility limitations: a randomized controlled trial

2008 • 147 citations

Testosterone Supplementation in Older Men: A Rational Idea Whose Time Has Not Yet Come

2001 • 133 citations

Effect of whey protein isolate on strength, body composition and muscle hypertrophy during resistance training

2008 • 133 citations

Antihypertensive Medications and Differences in Muscle Mass in Older Persons: The Health, Aging and Body Composition Study

2004 • 132 citations

Epidemiology of Sarcopenia

2000 • 121 citations

Appendicular lean tissue mass and the prevalence of sarcopenia among healthy women

2002 • 120 citations

Relation between body fat and age in 4 ethnic groups

1999 • 119 citations

Functional impact of high protein intake on healthy elderly people

2008 • 115 citations

Aging and the growth hormone/insulin like growth factor-I axis

2007 • 110 citations

Physical Activity, Inflammation, and Muscle Loss

2008 • 108 citations

Increased availability of leucine with leucine-rich whey proteins improves postprandial muscle protein synthesis in aging rats

2007 • 108 citations

Defining Sarcopenia in Terms of Risk of Physical Limitations: A 5‐Year Follow‐Up Study of 3,153 Chinese Men and Women

2009 • 107 citations

Changes in body composition and its relation to muscle strength in 75-year-old men and women: A 5-year prospective follow-up study of the NORA cohort in Göteborg, Sweden

2009 • 106 citations

Osteoporosis and gait and balance disturbances in older sarcopenic obese New Zealanders

2009 • 100 citations

High-Speed Power Training: A Novel Approach to Resistance Training in Older Men and Women. A Brief Review and Pilot Study

2007 • 98 citations

Physical Activity, Inflammation, and Muscle Loss

2007 • 98 citations

Androgens and Women at the Menopause and Beyond

2003 • 96 citations

A longitudinal assessment of change in &OV0312;O2max and maximal heart rate in master athletes

2001 • 95 citations

The Relations of Body Composition and Adiposity Measures to Ill Health and Physical Disability in Elderly Men

2006 • 93 citations

Age-related decline in RMR in physically active men: relation to exercise volume and energy intake

2001 • 89 citations

Insulin‐like growth factor‐1 (IGF‐1) and leucine activate pig myogenic satellite cells through mammalian target of rapamycin (mTOR) pathway

2007 • 85 citations

Age-associated decrease in contraction-induced activation of downstream targets of Akt/mTor signaling in skeletal muscle

2005 • 83 citations

Fat Mass But Not Fat-Free Mass Is Related to Physical Capacity in Well-Functioning Older Individuals: Nutrition as a Determinant of Successful Aging (NuAge)--The Quebec Longitudinal Study

2007 • 77 citations

Sarcopenic Obesity: An Emerging Cause of Frailty in Older Adults

2008 • 77 citations

Body composition in French women 75+ years of age: The EPIDOS study

2003 • 73 citations

Cross-sectional relationship between physical fitness components and functional performance in older persons living in long-term care facilities

2006 • 71 citations

Short-term protein and energy supplementation activates nitrogen kinetics and accretion in poorly nourished elderly subjects

2000 • 70 citations

Effect of Power-Training Intensity on the Contribution of Force and Velocity to Peak Power in Older Adults

2008 • 70 citations

Analyzing vitamin D in foods and supplements: methodologic challenges

2008 • 66 citations

Muscle Protein Metabolism and the Sarcopenia of Aging

2001 • 62 citations

Body composition in the elderly: the influence of nutritional factors and physical activity.

2003 • 61 citations

Successful Dissemination of a Community‐Based Strength Training Program for Older Adults by Peer and Professional Leaders: The People Exercising Program

2008 • 60 citations

Discovery of Potent and Muscle Selective Androgen Receptor Modulators through Scaffold Modifications

2007 • 57 citations

The potential benefits of creatine and conjugated linoleic acid as adjuncts to resistance training in older adults

2008 • 44 citations

Impact of Strength and Resistance Training on Cardiovascular Disease Risk Factors and Outcomes in Older Adults

2009 • 43 citations

ACE inhibitors as a therapy for sarcopenia — Evidence and possible mechanisms

2008 • 35 citations

Nutrition and muscle protein metabolism in the elderly.

2000 • 26 citations

Photobiology of Vitamin D

2011 • 22 citations

Epidemiology of sarcopenia

2000 • 21 citations

The end of body composition methodology research?

2005 • 20 citations

Ornithine alpha-ketoglutarate: Could it be a new therapeutic option for sarcopenia?

2010 • 17 citations

Skeletal muscle mass and muscle strength in relation to lower-extremity performance in older men and women

2000 • 16 citations

Mitochondrial function in physically active elders with sarcopenia

2009 • 16 citations

Management of Heart Failure in Older Adults

2006 • 10 citations

Sarcopenia and Sarcopenic-Obesity

2006 • 8 citations

Testosterone and Growth Hormone Improve Body Composition and Muscle Performance in Older Men

2010 • 5 citations

The Contribution of Reactive Oxygen Species in Sarcopenia and Muscle Aging

2007 • 3 citations