Research Agenda for Frailty in Older Adults: Toward a Better Understanding of Physiology and Etiology: Summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults

Frailty in Older Adults: Evidence for a Phenotype

2001 • 20,411 citations

Exercise Training and Nutritional Supplementation for Physical Frailty in Very Elderly People

1994 • 2,823 citations

Association between telomere length in blood and mortality in people aged 60 years or older

2003 • 1,740 citations

Age-Associated Increased Interleukin-6 Gene Expression, Late-Life Diseases, and Frailty

2000 • 1,245 citations

Loss of 'Complexity' and Aging

1992 • 1,146 citations

The Pathophysiologic Roles of Interleukin-6 in Human Disease

1998 • 1,132 citations

Designing Randomized, Controlled Trials Aimed at Preventing or Delaying Functional Decline and Disability in Frail, Older Persons: A Consensus Report

2004 • 998 citations

Frailty and Activation of the Inflammation and Coagulation Systems With and Without Clinical Comorbidities<subtitle>Results From the Cardiovascular Health Study</subtitle>

2002 • 909 citations

Sarcopenic Obesity Predicts Instrumental Activities of Daily Living Disability in the Elderly

2004 • 888 citations

A Program to Prevent Functional Decline in Physically Frail, Elderly Persons Who Live at Home

2002 • 853 citations

Oxidative Stress as a Regulator of Gene Expression in the Vasculature

1999 • 810 citations

Leg Muscle Mass and Composition in Relation to Lower Extremity Performance in Men and Women Aged 70 to 79: The Health, Aging and Body Composition Study

2002 • 809 citations

Elevations of Inflammatory and Procoagulant Biomarkers in Elderly Persons With Renal Insufficiency

2003 • 789 citations

Calorie restriction and aging: review of the literature and implications for studies in humans

2003 • 691 citations

Preventing Frail Health

1992 • 639 citations

Dynamics of Stability: The Physiologic Basis of Functional Health and Frailty

2002 • 599 citations

Principles of Geriatric Medicine and Gerontology

2004 • 581 citations

Exogenous Testosterone (T) Alone or with Finasteride Increases Physical Performance, Grip Strength, and Lean Body Mass in Older Men with Low Serum T

2005 • 564 citations

Sarcopenia and Age-Related Changes in Body Composition and Functional Capacity

1993 • 543 citations

Muscle tissue changes with aging

2004 • 450 citations

The Association Between Obesity and the Frailty Syndrome in Older Women: The Women's Health and Aging Studies

2005 • 423 citations

Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study

2003 • 394 citations

Serum Interleukin‐6 and Hemoglobin as Physiological Correlates in the Geriatric Syndrome of Frailty: A Pilot Study

2002 • 380 citations

Frailty in older adults: insights and interventions.

2005 • 356 citations

Gait instability and fractal dynamics of older adults with a “cautious” gait: why do certain older adults walk fearfully?

2004 • 329 citations

Relation between use of angiotensin-converting enzyme inhibitors and muscle strength and physical function in older women: an observational study

2002 • 326 citations

Adipogenesis and aging: does aging make fat go MAD?

2002 • 319 citations

Telomere maintenance and disease

2003 • 312 citations

Catabolism of aging: is it an inflammatory process?

2003 • 298 citations

Oxidative Stress, Chromatin Remodeling and Gene Transcription in Inflammation and Chronic Lung Diseases

2003 • 292 citations

Insulin-Like Growth Factor I and Interleukin-6 Contribute Synergistically to Disability and Mortality in Older Women

2003 • 288 citations

How to Select a Frail Elderly Population? A Comparison of Three Working Definitions

1999 • 262 citations

Serum levels of insulin-like growth factor-I (IGF-I) and dehydroepiandrosterone sulfate (DHEA-S), and their relationships with serum interleukin-6, in the geriatric syndrome of frailty

2004 • 257 citations

Clinical Global Impression of Change in Physical Frailty: Development of a Measure Based on Clinical Judgment

2004 • 248 citations

When human walking becomes random walking: fractal analysis and modeling of gait rhythm fluctuations

2001 • 231 citations

Sarcopenic Obesity: Does Muscle Loss Cause Fat Gain?: Lessons from Rheumatoid Arthritis and Osteoarthritis^a

2000 • 229 citations

Caloric Restriction and Aging

1996 • 219 citations

Cellular senescence and apoptosis: how cellular responses might influence aging phenotypes

2003 • 209 citations

Erythropoietin: a candidate compound for neuroprotection in schizophrenia

2003 • 207 citations

What Constitutes Normal Hemoglobin Concentration in Community‐Dwelling Disabled Older Women?

2004 • 190 citations

Influence of Visual Control, Conduction, and Central Integration on Static and Dynamic Balance in Healthy Older Adults

1997 • 147 citations

Cellular and Molecular Basis of Age-Related Sarcopenia

2002 • 147 citations

Emerging relationships of inflammation, cardiovascular disease and chronic diseases of aging

2003 • 142 citations

Effect of 1-Year Oral Administration of Dehydroepiandrosterone to 60- to 80-Year-Old Individuals on Muscle Function and Cross-sectional Area

2003 • 138 citations

Erythropoietin: Novel Approaches to Neuroprotection in Human Brain Disease

2004 • 124 citations

Total and Differential White Blood Cell Counts and Their Associations With Circulating Interleukin-6 Levels in Community-Dwelling Older Women

2005 • 87 citations

Influence of Regular Proprioceptive and Bioenergetic Physical Activities on Balance Control in Elderly Women

2003 • 74 citations

Dehydroepiandrosterone-Sulfate Inhibits Nuclear Factor-κB-Dependent Transcription in Hepatocytes, Possibly through Antioxidant Effect

2004 • 61 citations

Insulin-like growth factor-1 activity is inhibited by interleukin-1 alpha, tumor necrosis factor-alpha, and interleukin-6.

1993 • 60 citations

The Mitochondrial Theory of Aging

2001 • 60 citations

The mitochondrial theory of aging: Involvement of mitochondrial DNA damage and repair

2002 • 40 citations

Calorie restriction and aging

1996 • 30 citations

Conference on the physiologic basis of frailty. April 28, 1992, Baltimore, Maryland, U.S.A. Introduction.

1992 • 25 citations

Geriatric Palliative Care

2014 • 18 citations

Clinical Global Impression of Change in Physical Frailty

2004 • 13 citations

Interleukin balance and early recovery from anesthesia in elderly surgical patients exposed to β-adrenergic antagonism

2003 • 12 citations