Orally active growth hormone secretagogues: state of the art and clinical perspectives

A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release

1996 • 2,048 citations

Effects of Human Growth Hormone in Men over 60 Years Old

1990 • 1,560 citations

A Preliminary Study of Growth Hormone in the Treatment of Dilated Cardiomyopathy

1996 • 509 citations

Growth Hormone (GH)-Releasing Peptide Stimulates GH Release in Normal Men and Acts Synergistically with GH-Releasing Hormone*

1990 • 315 citations

On the Actions of the Growth Hormone-Releasing Hexapeptide, GHRP*

1991 • 308 citations

The Synergistic Effects of His-D-Trp-Ala-Trp-D-Phe- Lys-NH₂on Growth Hormone (GH)-Releasing Factor- Stimulated GH Release and Intracellular Adenosine 3',5'-Monophosphate Accumulation in Rat Primary Pituitary Cell Culture

1989 • 298 citations

Induction of c-fos Messenger Ribonucleic Acid in Neuropeptide Y and Growth Hormone (GH)-Releasing Factor Neurons in the Rat Arcuate Nucleus Following Systemic Injection of the GH Secretagogue, GH-Releasing Peptide-6*

1997 • 285 citations

Corticotropin-Releasing Hormone in Humans*

1992 • 283 citations

Molecular endocrinology

1978 • 258 citations

Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects.

1996 • 256 citations

Pituitary adenylate cyclase activating polypeptide, growth hormone (GH)-releasing peptide and GH-releasing hormone stimulate GH release through distinct pituitary receptors.

1992 • 238 citations

Blocked growth hormone-releasing peptide (GHRP-6)-induced GH secretion and absence of the synergic action of GHRP-6 plus GH-releasing hormone in patients with hypothalamopituitary disconnection: evidence that GHRP-6 main action is exerted at the hypothalamic level.

1995 • 189 citations

Growth Hormone Releasing Peptides

1996 • 188 citations

GH Releasing Peptides - Structure and Kinetics

1993 • 181 citations

Conformational Energy Studies andin Vitroandin VivoActivity Data on Growth Hormone-Releasing Peptides*

1984 • 179 citations

Growth hormone (GH)-releasing hormone secretion is stimulated by a new GH-releasing hexapeptide in sheep.

1994 • 163 citations

Growth hormone-releasing activity of hexarelin, a new synthetic hexapeptide, after intravenous, subcutaneous, intranasal, and oral administration in man.

1994 • 155 citations

Binding of a growth hormone releasing hexapeptide to specific hypothalamic and pituitary binding sites

1989 • 148 citations

The Somatotropic Axis in Critical Illness: Effect of Continuous Growth Hormone (GH)-Releasing Hormone and GH-Releasing Peptide-2 Infusion¹

1997 • 141 citations

The Effects of a Growth Hormone‐Releasing Peptide and Growth Hormone‐Releasing Factor in Conscious and Anaesthetized Rats

1989 • 123 citations

Growth Hormone-Releasing Peptide-6 Stimulates Sleep, Growth Hormone, ACTH and Cortisol Release in Normal Man

1995 • 116 citations

Intracerebroventricular growth-hormone-releasing peptide-6 stimulates eating without affecting plasma growth hormone responses in rats

1995 • 114 citations

Growth hormone-releasing peptide and its analogues

1995 • 113 citations

The Effects of Growth Hormone (GH)-Releasing Peptides on GH Secretion in Perifused Pituitary Cells of Adult Male Rats*

1984 • 106 citations

Twenty-four-hour growth hormone (GH)-releasing peptide (GHRP) infusion enhances pulsatile GH secretion and specifically attenuates the response to a subsequent GHRP bolus.

1993 • 106 citations

Activation of the Hypothalamo-Pituitary-Adrenal Axis by the Growth Hormone (GH) Secretagogue, GH-Releasing Peptide-6, in Rats

1997 • 104 citations

Mediation by the central nervous system is critical to the in vivo activity of the GH secretagogue L-692,585

1996 • 101 citations

Effects of a prolonged growth hormone (GH)-releasing peptide infusion on pulsatile GH secretion in normal men.

1993 • 97 citations

Growth hormone response in man to L-692,429, a novel nonpeptide mimic of growth hormone-releasing peptide-6.

1993 • 97 citations

Impaired growth hormone secretion in obese subjects is partially reversed by acipimox-mediated plasma free fatty acid depression.

1996 • 92 citations

Parallel Studies of His-<scp>D</scp>Trp-Ala-Trp-<scp>D</scp>Phe-Lys-NH₂and Human Pancreatic Growth Hormone-Releasing Factor-44-NH₂in Rat Primary Pituitary Cell Monolayer Culture*

1985 • 90 citations

Central effects of growth hormone-releasing hexapeptide (GHRP-6) on growth hormone release are inhibited by central somatostatin action

1995 • 88 citations

Effects of GHRP-2 and Hexarelin, Two Synthetic GH-Releasing Peptides, on GH, Prolactin, ACTH and Cortisol Levels in Man. Comparison with the Effects of GHRH, TRH and hCRH

1997 • 84 citations

Influence of sex, age and adrenergic pathways on the growth hormone response to GHRP-6

1993 • 83 citations

Effects of acute and repeated intravenous administration of L-692,585, a novel non-peptidyl growth hormone secretagogue, on plasma growth hormone, IGF-1, ACTH, cortisol, prolactin, insulin, and thyroxine levels in beagles

1994 • 83 citations

The Growth Hormone Response to Hexarelin in Children: Reproducibility and Effect of Sex Steroids1

1997 • 81 citations

Arginine and growth hormone-releasing hormone restore the blunted growth hormone-releasing activity of hexarelin in elderly subjects.

1994 • 81 citations

Effect of growth hormone (GH)-releasing hormone (GHRH), atropine, pyridostigmine, or hypoglycemia on GHRP-6-induced GH secretion in man.

1993 • 81 citations

Adrenocorticotropin- and Cortisol-Releasing Effect of Hexarelin, a Synthetic Growth Hormone-Releasing Peptide, in Normal Subjects and Patients with Cushing’s Syndrome¹

1997 • 81 citations

Cardiac ischemia and impairment of vascular endothelium function in hearts from GH-deficient rats: Protection by hexarelin

1997 • 78 citations

Acquired growth hormone resistance

1995 • 78 citations

Effects of a 7-day treatment with a novel, orally active, growth hormone (GH) secretagogue, MK-677, on 24-hour GH profiles, insulin-like growth factor I, and adrenocortical function in normal young men.

1996 • 75 citations

Neuroendocrine responses to a novel growth hormone secretagogue, L-692,429, in healthy older subjects.

1994 • 74 citations

Atypical Growth Hormone Releasing Peptides

1994 • 70 citations

Modulation of Growth Hormone-Releasing Activity of Hexarelin in Man

1995 • 69 citations

Absence of growth hormone (GH) secretion after the administration of either GH-releasing hormone (GHRH), GH-releasing peptide (GHRP-6), or GHRH plus GHRP-6 in children with neonatal pituitary stalk transection.

1995 • 68 citations

Variables Determining the Growth Hormone Response of His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂in the Rat*

1985 • 67 citations

Effects of the enkephalins and enkephalin analogs on release of pituitary hormones in vitro

1977 • 65 citations

Widespread transcription of the growth hormone-releasing peptide receptor gene in neuroendocrine human tumors

1997 • 65 citations

Growth Hormone II: Basic and Clinical Aspects

2011 • 64 citations

Growth hormone (GH)-releasing peptide stimulation of GH release from human somatotroph adenoma cells: interaction with GH-releasing hormone, thyrotropin-releasing hormone, and octreotide.

1994 • 64 citations

Growth Hormone (GH) Responses to the Hexapeptide GH-Releasing Peptide and GH-Releasing Hormone (GHRH) in the Cynomolgus Macaque: Evidence for Non-GHRH-Mediated Responses*

1991 • 59 citations

Regulation of His-dTrp-Ala-Trp-dPhe-Lys-NH2 (GHRP-6)-lnduced GH Secretion in the Rat

1993 • 59 citations

Inhibition of growth hormone release after the combined administration of CHRH and GHRP‐6 in patients with Cushing's syndrome

1994 • 58 citations

The Growth Hormone Secretagogue, L-692,429, Induces Phosphatidylinositol Hydrolysis and Hormone Secretion by Human Pituitary Tumors

1995 • 58 citations

Growth hormone (GH) responses to the combined administration of GH-releasing hormone plus GH-releasing peptide 6 in adults with GH deficiency

1995 • 56 citations

Constitutive Growth Hormone Secretion in Sheep after Hypothalamopituitary Disconnection and the Direct in vivo Pituitary Effect of Growth Hormone Releasing Peptide 6

1994 • 55 citations

Growth Hormone Secretagogues

1995 • 54 citations

Metabolic modulation of the growth hormone-releasing activity of hexarelin in man

1995 • 53 citations

Growth Hormone (GH) Secretion during Continuous Infusion of GH-Releasing Peptide: Partial Response Attenuation*

1991 • 53 citations

Mechanism of Action of Hexarelin and GHRP-6: Analysis of the Involvement of GHRH and Somatostatin in the Rat

1995 • 49 citations

MK-0677, a potent, novel, orally active growth hormone (GH) secretagogue: GH, insulin-like growth factor I, and other hormonal responses in beagles.

1996 • 48 citations

The effect of an opiate antagonist on the hormonal changes induced by hexarelin

1995 • 48 citations

The GH, prolactin, ACTH and cortisol responses to Hexarelin, a synthetic hexapeptide, undergo different age-related variations

1997 • 46 citations

Hexarelin, a Synthetic Growth-Hormone Releasing Peptide, Shows No Interaction with Corticotropin-Releasing Hormone and Vasopressin on Adrenocorticotropin and Cortisol Secretion in Humans

1997 • 45 citations

Hexarelin, a synthetic growth hormone releasing peptide, stimulates prolactin secretion in acromegalic but not in hyperprolactinaemic patients

1996 • 42 citations

Diagnostic studies with intravenous and intranasal growth hormone-releasing peptide-2 in children of short stature.

1995 • 41 citations

Effect of the potentiation of cholinergic activity on the variability in individual GH response to GH-releasing hormone

1989 • 40 citations

Growth hormone-releasing activity of hexarelin, a new synthetic hexapeptide, before and during puberty.

1995 • 40 citations

Thyroid cancer histotype changes as observed in a major general hospital in a 21-year period

1997 • 40 citations

Mechanisms underlying the negative growth hormone (GH) autofeedback on the GH-releasing effect of hexarelin in man

1997 • 35 citations

Short-term administration of intranasal or oral Hexarelin, a synthetic hexapeptide, does not desensitize the growth hormone responsiveness in human aging

1996 • 35 citations

Oestrogen replacement does not restore the reduced GH-releasing activity of Hexarelin, a synthetic hexapeptide, in post-menopausal women

1997 • 35 citations

Growth Hormone-Releasing Hexapeptide Is a Potent Stimulator of Growth Hormone Gene Expression and Release in the Growth Hormone—Releasing Hormone—Deprived Infant Rat

1994 • 34 citations

Growth hormone-releasing activity of growth hormone-releasing peptide-6 is maintained after short-term oral pretreatment with the hexapeptide in normal aging

1994 • 33 citations

L-692,429, a nonpeptide growth hormone (GH) secretagogue, reverses glucocorticoid suppression of GH secretion.

1994 • 32 citations

Consistent GH responses to repeated injections of GH-releasing hexapeptide (GHRP-6) and the non-peptide GH secretagogue, L-692,585

1995 • 31 citations

The effect of hexarelin on growth hormone (GH) secretion in patients with GH deficiency.

1995 • 31 citations

The growth hormone (GH) response to GH-releasing peptide (His-DTrp-Ala-Trp-DPhe-Lys-NH2), GH-releasing hormone, and thyrotropin-releasing hormone in acromegaly.

1993 • 30 citations

Hexarelin induced growth hormone release is influenced by exogenous growth hormone

1995 • 29 citations

Hexarelin, a potent GHRP analogue: Interactions with GHRH and clonidine in young and aged dogs

1995 • 27 citations

Small Peptides as Potent Releasers of Growth Hormone

1995 • 27 citations

Growth hormone (GH) secretion in active acromegaly after the combined administration of GH-releasing hormone and GH-releasing peptide-6.

1994 • 25 citations

Growth hormone-releasing effect of oral growth hormone-releasing peptide 6 (GHRP-6) administration in children with short stature

1995 • 24 citations

Different growth hormone (GH) response to GH-releasing peptide and GH-releasing hormone in hyperthyroidism.

1996 • 21 citations

Influence of beta-adrenergic agonists and antagonists on the GH-releasing effect of Hexarelin in man

1996 • 19 citations

Plasma growth hormone response to growth hormone‐releasing hexapeptide (GH‐RP‐6) in children with short stature

1995 • 19 citations

Effects of hypothyroidism, tri-iodothyronine and glucocorticoids on growth hormone responses to growth hormone-releasing hormone and His-d-Trp-Ala-Trp-d-Phe-Lys-NH2

1989 • 18 citations

Effects of histaminergic antagonists on the GH-releasing activity of GHRH or hexarelin, a synthetic hexapeptide, in man

1997 • 17 citations

Somatotrope responsiveness to Hexarelin, a synthetic hexapeptide, is refractory to the inhibitory effect of glucose in obesity

1996 • 14 citations

Evaluation of pituitary GH reserve with GHRP-6.

1996 • 13 citations

Influence of endogenous cholinergic tone and α-adrenergic pathways on growth hormone responses to His-d-Trp-Ala-Trp-d-Phe-Lys-NH2 in the dog

1993 • 13 citations

Effects of Growth Hormone Releasing Peptides on Stimulated Growth Hormone Secretion in Old Rats

1994 • 11 citations

Hexarelin, a novel GHRP-6 analog, stimulates growth hormone (GH) release in a GH-secreting rat cell line (GH1) insensitive to GH-releasing hormone

1997 • 11 citations

Neurokinin Receptor Antagonists Inhibit the Binding of Growth Hormone-Releasing Peptide to EP-1 Human Neuroblastoma Cells

1995 • 2 citations