Proinflammatory Cytokines Inhibit Secretion in Rat Bile Duct Epithelium

Tumor necrosis factor and interleukin 1: cytokines with multiple overlapping biological activities.

1987 • 1,345 citations

Cytoplasmic pH and free Mg2+ in lymphocytes.

1982 • 1,047 citations

Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayers.

1989 • 761 citations

Ursodiol for the Long-Term Treatment of Primary Biliary Cirrhosis

1994 • 477 citations

Ursodeoxycholic acid for treatment of primary sclerosing cholangitis: A placebo-controlled trial

1992 • 449 citations

Cytokines and Fibrogenesis

1999 • 358 citations

Localization of the cystic fibrosis transmembrane conductance regulator in human bile duct epithelial cells

1993 • 347 citations

Mitosis and apoptosis in the liver of interleukin-6-deficient mice after partial hepatectomy

1999 • 264 citations

Rat cholangiocytes absorb bile acids at their apical domain via the ileal sodium-dependent bile acid transporter.

1997 • 250 citations

Oral budesonide and ursodeoxycholic acid for treatment of primary biliary cirrhosis: Results of a prospective double-blind trial

1999 • 248 citations

Immunohistochemical detection of chloride/bicarbonate anion exchangers in human liver

1994 • 165 citations

In situ nucleic acid hybridization of cytokines in primary biliary cirrhosis: Predominance of the Th1 subset

1997 • 164 citations

Synergistic effects of interferon γ and tumour necrosis factor α on T84 cell function

1999 • 158 citations

Secretin stimulates exocytosis in isolated bile duct epithelial cells by a cyclic AMP-mediated mechanism.

1992 • 151 citations

Cell-permeable fluorescent indicator for cytosolic chloride

1991 • 146 citations

Bile ductular cholestasis: An ominous histopathologic sign related to sepsis and “cholangitis lenta”

1982 • 142 citations

Upregulation of secretin receptor gene expression in rat cholangiocytes after bile duct ligation

1994 • 141 citations

Development and characterization of polarized primary cultures of rat intrahepatic bile duct epithelial cells.

1996 • 140 citations

Increased expression of interleukin-6 and tumor necrosis factor-alpha in pathologic biliary epithelial cells: in situ and culture study.

1998 • 130 citations

Cytokine patterns and cytotoxic mediators in primary biliary cirrhosis

1995 • 129 citations

Growth control of human biliary epithelial cells by interleukin 6, hepatocyte growth factor, transforming growth factor β1, and activin a: Comparison of a cholangiocarcinoma cell line with primary cultures of non-neoplastic biliary epithelial cells

2000 • 127 citations

Effect of secretion on intracellular pH regulation in isolated rat bile duct epithelial cells.

1993 • 124 citations

Liver and Biliary Problems in Cystic Fibrosis

1998 • 118 citations

Intercellular adhesion molecule-1 and MHC antigens on human intrahepatic bile duct cells: effect of pro-inflammatory cytokines.

1993 • 116 citations

Intracellular pH regulation in isolated rat bile duct epithelial cells.

1991 • 110 citations

Isolation of small polarized bile duct units.

1995 • 107 citations

Pathophysiology of the intrahepatic biliary epithelium

2000 • 88 citations

Assessment of inflammatory events in epithelial permeability: a rapid screening method using fluorescein dextrans.

1995 • 87 citations

Regulation of biliary secretion through apical purinergic receptors in cultured rat cholangiocytes

1997 • 77 citations

Disappearing Intrahepatic Bile Ducts: The Syndromes and Their Mechanisms

1993 • 75 citations

Gamma‐Interferon‐Mediated Down‐Regulation of Electrolyte Secretion by Intestinal Epithelial Cells: A Local Immune Mechanism?

1989 • 69 citations

Kinetic and molecular identification of sodium-dependent glucose transporter in normal rat cholangiocytes

1997 • 69 citations

Hormonal regulation of paracellular permeability in isolated rat hepatocyte couplets

1992 • 65 citations

Cytokines in Primary Biliary Cirrhosis

1997 • 61 citations

Hepatocyte tight-junctional permeability is increased in rat experimental colitis

1997 • 61 citations

Na+-dependent and -independent Cl?/HCO3? exchange mediate cellular HCO3? transport in cultured human intrahepatic bile duct cells

1997 • 57 citations

Quantitative assessment of canalicular bile formation in isolated hepatocyte couplets using microscopic optical planimetry.

1989 • 54 citations

Role of kinases and phosphatases in the regulation of fluid secretion and Cl-/HCO3- exchange in cholangiocytes

1997 • 53 citations

Quantitative fluorescence measurements of chloride secretion in native airway epithelium from CF and non-CF subjects.

1995 • 52 citations

Activation of Excitatory Amino Acid Receptors in the Rat Hippocampal Slice Increases Intracellular Cl⁻ and Cell Volume

1998 • 52 citations

Effects of ursodeoxycholic acid after 4 to 12 years of therapy in early and late stages of primary biliary cirrhosis

1994 • 48 citations

Cl(-)-dependent NH4+ transport mechanisms in medullary thick ascending limb cells

1994 • 48 citations

Functional polarity of Na⁺/H⁺and Cl⁻/ HCO 3 − exchangers in a rat cholangiocyte cell line

1998 • 47 citations

Immunologic Mechanisms of Hepatic Allograft Rejection

1992 • 46 citations

Nucleotide receptors activate cation, potassium, and chloride currents in a liver cell line

1994 • 41 citations

Control of Intracellular pH

2012 • 40 citations

Chloride currents in primary cultures of rabbit proximal and distal convoluted tubules

1998 • 36 citations

Stimulation of bile duct epithelial secretion by glybenclamide in normal and cholestatic rat liver.

1998 • 27 citations

Gamma-interferon inhibits secretin-induced choleresis and cholangiocyte proliferation in a murine model of cirrhosis

1997 • 26 citations

The Intrahepatic Cholangiopathies

1998 • 24 citations

Effect of ursodeoxycholic acid on intracellular pH in a bile duct epithelium-like cell line

1994 • 23 citations

Pathobiology of biliary epithelia

1994 • 16 citations

Immunopathogenesis of autoimmune hepatobiliary diseases

1994 • 7 citations

Identification of cytokine protein expression in human liver allograft rejection: methods development and expression of IL-1 beta, IL-6, IFN-gamma, and basic fibroblast growth factor.

1992 • 6 citations