Cytokine patterns and cytotoxic mediators in primary biliary cirrhosis

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Recombinant human interleukin 5 is a selective activator of human eosinophil function.

1988 • 976 citations

Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by TH1 clones.

1987 • 966 citations

Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma.

1991 • 841 citations

MALARIAL DIABETES

1948 • 829 citations

Messenger RNA expression of the cytokine gene cluster, interleukin 3 (IL-3), IL-4, IL-5, and granulocyte/macrophage colony-stimulating factor, in allergen-induced late-phase cutaneous reactions in atopic subjects.

1991 • 676 citations

Highly purified murine interleukin 5 (IL-5) stimulates eosinophil function and prolongs in vitro survival. IL-5 as an eosinophil chemotactic factor.

1988 • 619 citations

Eosinophilia in transgenic mice expressing interleukin 5.

1990 • 579 citations

IDENTIFICATION BY IMMUNOFLUORESCENCE OF EOSINOPHIL GRANULE MAJOR BASIC PROTEIN IN LUNG TISSUES OF PATIENTS WITH BRONCHIAL ASTHMA

1982 • 522 citations

ABERRANT EXPRESSION OF HLA-DR ANTIGENS ON BILEDUCT EPITHELIUM IN PRIMARY BILIARY CIRRHOSIS: RELEVANCE TO PATHOGENESIS

1984 • 496 citations

Autoimmune Diseases: The Failure of Self Tolerance

1990 • 495 citations

Type beta transforming growth factor reversibly inhibits the early proliferative response to partial hepatectomy in the rat.

1988 • 424 citations

Reversal of fulminant hepatic failure using an extracorporeal liver assist device

1992 • 341 citations

Regulatory effect of cytokines on eosinophil degranulation.

1990 • 337 citations

The eosinophil as a mediator of damage to respiratory epithelium: A model for bronchial hyperreactivity

1988 • 317 citations

Identification of a lymphokine that stimulates eosinophil differentiation in vitro. Its relationship to interleukin 3, and functional properties of eosinophils produced in cultures.

1985 • 296 citations

Transforming growth factors beta 1 and beta 2 are differentially expressed in fibrotic liver disease.

1991 • 266 citations

Interleukin 5 messenger RNA expression by eosinophils in the intestinal mucosa of patients with coeliac disease.

1992 • 244 citations

IL-2 and IFN-gamma are two necessary lymphokines in the development of cytolytic T cells.

1989 • 234 citations

Detection of Autoantibodies to Recombinant Mitochondrial Proteins in Patients with Primary Biliary Cirrhosis

1989 • 206 citations

Primary biliary cirrhosis: Paradigm or paradox for autoimmunity

1991 • 204 citations

Generation of biliary lesions after transfer of human lymphocytes into severe combined immunodeficient (SCID) mice.

1989 • 177 citations

Perforin and serine esterase gene expression in stimulated human T cells. Kinetics, mitogen requirements, and effects of cyclosporin A.

1989 • 144 citations

CYTOKINE AND T CELL RECEPTOR GENE EXPRESSION AT THE SITE OF ALLOGRAFT REJECTION1

1992 • 140 citations

Evidence for the targeting by 2-oxo-dehydrogenase enzymes in the T cell response of primary biliary cirrhosis.

1991 • 139 citations

INTRAGRAFT CYTOKINE PROFILE DURING HUMAN LIVER ALLOGRAFT REJECTION 1, 2

1992 • 116 citations

Immunization of experimental animals with dihydrolipoamide acetyltransferase, as a purified recombinant polypeptide, generates mitochondrial antibodies but not primary biliary cirrhosis

1989 • 109 citations

Analysis of hepatic T lymphocyte and immunoglobulin deposits in patients with primary biliary cirrhosis

1990 • 106 citations

Hypodense eosinophils and interleukin 5 activity in the blood of patients with the eosinophilia-myalgia syndrome.

1990 • 97 citations

The role of interleukin 2 in autoimmunity

1989 • 89 citations

EVIDENCE FOR A NONCLASSICAL PATHWAY OF GRAFT REJECTION INVOLVING INTERLEUKIN 5 AND EOSINOPHILS

1993 • 73 citations

Eosinophilic infiltration of the liver in primary biliary cirrhosis: A morphological study

1993 • 72 citations

Clonal analysis of human T lymphocytes infiltrating the liver in chronic active hepatitis B and primary biliary cirrhosis

1988 • 64 citations

Immunohistochemical characterization of inflammatory infiltrates in primary biliary cirrhosis

1984 • 61 citations

Blood and liver-infiltrating lymphocytes in primary biliary cirrhosis: Increase in activated T and natural killer cells and recruitment of primed memory T cells

1991 • 61 citations

Primary biliary cirrhosis.

1987 • 37 citations

Serum interleukin-2 and tumor necrosis factor-alpha in primary biliary cirrhosis: decrease by colchicine and relationship to HLA-DR4.

1992 • 33 citations

Clonal analysis of liver-derived T cells of patients with primary biliary cirrhosis.

1989 • 28 citations

Effect of recombinant interleukin 5 on the generation of cytotoxic T cells (CTL)

1991 • 21 citations

Nucleotide sequence and genomic organization of a human T lymphocyte serine protease gene.

1990 • 10 citations