Energy metabolism in demented brain

NEUROTRANSMITTER-RELATED ENZYMES AND INDICES OF HYPOXIA IN SENILE DEMENTIA AND OTHER ABIOTROPHIES

1976 • 1,272 citations

HUNTINGTON'S CHOREA

1974 • 527 citations

Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain

1983 • 355 citations

Effects of Human Aging on Patterns of Local Cerebral Glucose Utilization Determined by the [¹⁸F] Fluorodeoxyglucose Method

1982 • 327 citations

ACCELERATED AGEING OR SELECTIVE NEURONAL LOSS AS AN IMPORTANT CAUSE OF DEMENTIA?

1979 • 326 citations

Human brain glucose utilization and cognitive function in relation to age

1984 • 261 citations

Coenzyme a-acetylating enzymes in Alzheimer's disease: Possible cholinergic ‘compartment’ of pyruvate dehydrogenase

1980 • 232 citations

CEREBRAL GLUCOSE UTILIZATION, AS MEASURED WITH POSITRON EMISSION TOMOGRAPHY IN 21 RESTING HEALTHY MEN BETWEEN THE AGES OF 21 AND 83 YEARS

1983 • 229 citations

Aging Decreases Oxidative Metabolism and the Release and Synthesis of Acetylcholine

1981 • 215 citations

An immunochemical study of the pyruvate dehydrogenase deficit in Alzheimer's disease brain

1985 • 164 citations

BILATERAL STUDIES OF CEREBRAL OXYGEN UPTAKE IN YOUNG AND AGED NORMAL SUBJECTS AND IN PATIENTS WITH ORGANIC DEMENTIA

1960 • 161 citations

Effects of Aging on Cerebral Circulation and Metabolism in Man.

1963 • 157 citations

CEREBRAL PHYSIOLOGY OF THE AGED

1952 • 132 citations

Distribution of phosphate-activated glutaminase, succinic dehydrogenase, pyruvate dehydrogenase and γ-glutamyl transpeptidase in post-mortem brain from Huntington's disease and agonal cases

1985 • 131 citations

REGIONAL CEREBRAL BLOOD FLOW IN ORGANIC DEMENTIA WITH EARLY ONSET

2009 • 121 citations

Glycolytic enzymes from human autoptic brain cortex: Normal aged and demented cases

1980 • 117 citations

Mental Function and Cerebral Oxygen Consumption in Organic Dementia

1957 • 117 citations

Regional cerebral blood flow in senile and presenile dementia

1970 • 116 citations

Neurobiology and pharmacology of Huntington's disease

1977 • 96 citations

THE EFFECTS OF AGING, ARTERIOSCLEROSIS, AND HYPERTENSION UPON THE CEREBRAL CIRCULATION 1

1953 • 82 citations

Human aging, a biological and behavioral study

1964 • 71 citations

Phosphorylation‐Mediated Changes in Pyruvate Dehydrogenase Activity Influence Pyruvate‐Supported Calcium Accumulation by Brain Mitochondria

1981 • 68 citations

Cerebral circulatory and metabolic changes associated with aging.

1966 • 67 citations

Oxygen Dependence of Glucose and Acetylcholine Metabolism in Slices and Synaptosomes from Rat Brain

1981 • 62 citations

Evidence that a 41,000 dalton brain phosphoprotein is pyruvate dehydrogenase

1980 • 60 citations

Studies on the Pyruvate Dehydrogenase Complex in Brain with the Arylamine Acetyltransferase‐Coupled Assay

1982 • 57 citations

Carbohydrates and Acetylcholine Synthesis: Implications for Cognitive Disorders

1979 • 39 citations

Mental Symptoms in Huntington's Disease and a Possible Primary Aminergic Neuron Lesion

1980 • 35 citations

Consequences of mild, graded hypoxia.

1979 • 35 citations

REGIONAL CEREBRAL BLOOD FLOW IN ORGANIC DEMENTIA WITH EARLY ONSET

2009 • 33 citations

Effects of Aging on Cerebral Blood Flow in Dementia

1984 • 31 citations

BIOCHEMISTRY AND MENTAL DISORDER

1932 • 28 citations

Identification of a Mitochondrial Phosphoprotein in Brain Synaptic Membrane Preparations

1981 • 24 citations

Choline acetyltransferase and acetylcholinesterase abnormalities in senile dementia: Importance of biochemical measurements in human post-mortem brain specimens

1979 • 8 citations