Choline acetyltransferase and acetylcholinesterase abnormalities in senile dementia: Importance of biochemical measurements in human post-mortem brain specimens

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

A rapid radiochemical method for the determination of choline acetyltransferase

1975 • 2,406 citations

LABORATORY INVESTIGATION

1956 • 1,491 citations

Human Memory and the Cholinergic System

1974 • 1,378 citations

NEUROTRANSMITTER-RELATED ENZYMES AND INDICES OF HYPOXIA IN SENILE DEMENTIA AND OTHER ABIOTROPHIES

1976 • 1,272 citations

Radiochemical micro assays for the determination of choline acetyltransferase and acetylcholinesterase activities

1969 • 1,043 citations

Huntington's Chorea

1973 • 845 citations

Neurotransmitter enzyme abnormalities in senile dementia

1977 • 710 citations

Aging and Extrapyramidal Function

1977 • 650 citations

Memory and cognitive function in man

1977 • 624 citations

HUNTINGTON'S CHOREA

1974 • 527 citations

NEOCORTICAL CHOLINERGIC NEURONS IN ELDERLY PEOPLE

1977 • 490 citations

ALUMINIUM, NEUROFIBRILLARY DEGENERATION AND ALZHEIMER'S DISEASE

1976 • 453 citations

ENZYMES ASSOCIATED WITH THE METABOLISM OF CATECHOLAMINES, ACETYLCHOLINE AND GABA IN HUMAN CONTROLS AND PATIENTS WITH PARKINSON'S DISEASE AND HUNTINGTON'S CHOREA

1976 • 452 citations

THE PATTERN OF MAMMALIAN BRAIN GANGLIOSIDES‐II EVALUATION OF THE EXTRACTION PROCEDURES, POSTMORTEM CHANGES AND THE EFFECT OF FORMALIN PRESERVATION*

1965 • 425 citations

Neurofibrillary tangles of paired helical filaments

1976 • 366 citations

PHAGOCYTOSIS IN CHRONIC GRANULOMATOUS DISEASE

1975 • 363 citations

ACCELERATED AGEING OR SELECTIVE NEURONAL LOSS AS AN IMPORTANT CAUSE OF DEMENTIA?

1979 • 326 citations

CHEMICAL PATHOLOGY OF THE ORGANIC DEMENTIAS

1977 • 134 citations

A STUDY OF SELECTED CATECHOLAMINE METABOLIZING ENZYMES: A COMPARISON OF DEPRESSIVE SUICIDES AND ALCOHOLIC SUICIDES WITH CONTROLS¹

1974 • 112 citations

Selective vulnerability of neurones in organic dementia

1977 • 99 citations

Memory Enhancement After Physostigmine Treatment in the Amnesic Syndrome

1977 • 99 citations

Alzheimer's Disease and Related Conditions

1971 • 89 citations

BRAIN-DECARBOXYLASE ACTIVITIES AS INDICES OF PATHOLOGICAL CHANGE IN SENILE DEMENTIA

1974 • 71 citations

CHEMICAL PATHOLOGY OF THE ORGANIC DEMENTIAS

1977 • 70 citations

Post-mortem measurement of enzymes in human brain: Evidence of a central noradrenergic deficit in schizophrenia

1974 • 67 citations

MOLECULAR CHANGES IN SENILE DEMENTIA

1973 • 67 citations

Some Cerebral Proteins and Enzyme Systems in Alzheimer's Presenile and Senile Dementia

1976 • 62 citations

Studies in Ageing of the Brain

1972 • 61 citations

Enzymes associated with the metabolism of catecholamines, acetylcholine and gaba in human controls and patients with Parkinson's disease and Huntington's chorea.

1976 • 49 citations

ARCHITECTONIC DISTRIBUTION OF ACETYLCHOLINESTERASE IN THE FRONTAL ISOCORTEX OF PSYCHOTIC AND NONPSYCHOTIC PATIENTS

1952 • 39 citations

Biochemical indices of brain structure, function and ‘hypoxia’ in cortex from baboons with middle cerebral artery occlusion

1976 • 36 citations

Postmortem Changes in Brain Catecholamine Enzymes

1975 • 34 citations

THE INTRALAMINAR DISTRIBUTION OF DIPEPTIDASE ACTIVITY IN HUMAN FRONTAL ISOCORTEX*

1959 • 33 citations

THE VALIDATION OF THE QUANTITATIVE HISTOCHEMICAL METHOD FOR USE ON POST MORTEM MATERIAL?II.

1958 • 32 citations

The Localization of Glutamate Decarboxylase, Choline Acetyltransferase, and Aromatic Amino Acid Decarboxylase in Mammalian and Invertebrate Nervous Tissue

1975 • 28 citations

ESTIMATION OF GLYCOLIPIDS IN FOUR SELECTED LOBES OF HUMAN BRAIN IN NEUROLOGICAL DISEASES¹

1969 • 28 citations

The validation of the quantitative histochemical method for use on postmortem material. I. The effect of time and temperature.

1957 • 28 citations

Soluble proteins in normal and diseased human brains

1969 • 17 citations

SOLUBLE PROTEINS IN NORMAL and DISEASED HUMAN BRAIN

1976 • 15 citations

Biochemistry and Neurological Disease

1978 • 13 citations

Neurotransmitter-related enzymes in the major psychiatric disorders: II. MAO and DBH in schizophrenia.

1975 • 13 citations

Biochemistry of Middle and Late Life Dementias

1972 • 7 citations

The Effects of Middle-Cerebral-Artery Occlusion on Neurotransmitter Metabolism in Baboons

1977 • 7 citations