Amino-Terminal Hydrophobic Region of Helicobacter pylori Vacuolating Cytotoxin (VacA) Mediates Transmembrane Protein Dimerization

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

The GxxxG motif: A framework for transmembrane helix-helix association

2000 • 905 citations

The Comprehensive Sourcebook of Bacterial Protein Toxins

2015 • 601 citations

Statistical analysis of amino acid patterns in transmembrane helices: the GxxxG motif occurs frequently and in association with β-branched residues at neighboring positions

2000 • 588 citations

Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains.

1994 • 490 citations

TOXCAT: A measure of transmembrane helix association in a biological membrane

1999 • 343 citations

The vacuolating cytotoxin of Helicobacter pylori

1996 • 288 citations

Selective Inhibition of Ii-dependent Antigen Presentation by Helicobacter pylori Toxin VacA

1998 • 282 citations

Formation of anion-selective channels in the cell plasma membrane by the toxin VacA of Helicobacter pylori is required for its biological activity

1999 • 269 citations

Selective increase of the permeability of polarized epithelial cell monolayers by Helicobacter pylori vacuolating toxin.

1998 • 245 citations

Co‐ordinate expression of virulence genes by ToxR in Vibrio cholerae

1992 • 228 citations

Low pH Activates the Vacuolating Toxin of Helicobacter pylori, Which Becomes Acid and Pepsin Resistant

1995 • 217 citations

The vacuolating toxin from Helicobacter pylori forms hexameric pores in lipid bilayers at low pH

1999 • 212 citations

Differential mRNA stability of the cspA gene in the cold‐shock response of Escherichia coli

1996 • 210 citations

Acid-induced Dissociation of VacA, the Helicobacter pylori Vacuolating Cytotoxin, Reveals Its Pattern of Assembly

1997 • 199 citations

Oligomeric and subunit structure of the Helicobacter pylori vacuolating cytotoxin.

1996 • 185 citations

A Heptad Motif of Leucine Residues Found in Membrane Proteins Can Drive Self-assembly of Artificial Transmembrane Segments

1999 • 177 citations

Activation of Helicobacter pylori VacA Toxin by Alkaline or Acid Conditions Increases Its Binding to a 250-kDa Receptor Protein-tyrosine Phosphatase β

1999 • 160 citations

Helicobacter pylori Vacuolating Toxin Forms Anion-Selective Channels in Planar Lipid Bilayers: Possible Implications for the Mechanism of Cellular Vacuolation

1999 • 151 citations

VacA from Helicobacter pylori: a hexameric chloride channel

1999 • 139 citations

A Conserved Membrane-spanning Amino Acid Motif Drives Homomeric and Supports Heteromeric Assembly of Presynaptic SNARE Proteins

2000 • 132 citations

A Dominant Negative Mutant of Helicobacter pyloriVacuolating Toxin (VacA) Inhibits VacA-induced Cell Vacuolation

1999 • 131 citations

Site-specific mutagenesis using asymmetric polymerase chain reaction and a single mutant primer

1990 • 129 citations

Effect of Helicobacter pylori Vacuolating Toxin on Maturation and Extracellular Release of Procathepsin D and on Epidermal Growth Factor Degradation

1997 • 117 citations

Identification of the Helicobacter pylori VacA Toxin Domain Active in the Cell Cytosol

1998 • 114 citations

Identification of the Minimal Intracellular Vacuolating Domain of the Helicobacter pylori Vacuolating Toxin

1999 • 110 citations

Acid activation of Helicobacter pylori vacuolating cytotoxin (VacA) results in toxin internalization by eukaryotic cells

2000 • 91 citations

The Acid Activation ofHelicobacter pyloriToxin VacA: Structural and Membrane Binding Studies

1998 • 90 citations

3D imaging of the 58 kda cell binding subunit of the Helicobacter pylori cytotoxin

1999 • 79 citations

Inhibition of the vacuolating and anion channel activities of the VacA toxin of Helicobacter pylori

1999 • 76 citations

Towards deciphering the Helicobacter pylori cytotoxin

1999 • 75 citations

Lipid Interaction of the 37‐kDa and 58‐kDa Fragments of the Helicobacter Pylori Cytotoxin

1995 • 58 citations

Mutational Analysis of the Helicobacter pylori Vacuolating Toxin Amino Terminus: Identification of Amino Acids Essential for Cellular Vacuolation

2000 • 45 citations

Structure and interaction of VacA of Helicobacter pylori with a lipid membrane

2000 • 35 citations

Helicobacter pylori vacuolating cytotoxin and associated pathogenic factors

1999 • 23 citations

Membrane topology of VacA cytotoxin from H. pylori

2000 • 12 citations