Interleukin-6 in synovial fluid is closely associated with chronic synovitis in rheumatoid arthritis

The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis

1988 • 19,632 citations

Isolation of mononuclear cells and granulocytes from human blood.

1968 • 9,672 citations

Revised Criteria for the Classification of Rheumatoid Arthritis

1990 • 7,730 citations

Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.

1968 • 5,084 citations

Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes).

1984 • 3,268 citations

The Glomerular Permeability Determined by Dextran Clearance Using Sephadex Gel Filtration

1968 • 2,659 citations

Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells.

1987 • 1,667 citations

Production of hybridoma growth factor by human monocytes

1987 • 1,133 citations

Interleukin‐6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides

1988 • 859 citations

Interleukin‐6 is the major regulator of acute phase protein synthesis in adult human hepatocytes

1989 • 856 citations

Excessive production of interleukin 6/B cell stimulatory factor‐2 in rheumatoid arthritis

1988 • 793 citations

Purification to homogeneity and characterization of human B-cell differentiation factor (BCDF or BSFp-2).

1985 • 679 citations

Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritis.

1989 • 514 citations

Correlation of Serum Interleukin‐6 Levels with Joint Involvement and Thrombocytosis in Systemic Juvenile Rheumatoid Arthritis

1991 • 364 citations

IL-6 production by human articular chondrocytes. Modulation of its synthesis by cytokines, growth factors, and hormones in vitro.

1990 • 361 citations

B-cell-stimulatory factor 2 (beta 2 interferon) functions as a second signal for interleukin 2 production by mature murine T cells.

1987 • 357 citations

Monocyte-Derived Human B-Cell Growth Factor Identified as Interferon-β ₂ (BSF-2, IL-6)

1988 • 281 citations

The immunologic release of constituents from neutrophil leukocytes. II. Mechanisms of release during phagocytosis, and adherence to nonphagocytosable surfaces.

1971 • 246 citations

Analysis of the histologic variation of synovitis in rheumatoid arthritis

1988 • 217 citations

Identification of immunoglobulins and complement in rheumatoid articular collagenous tissues

1975 • 196 citations

Inflammatory microcrystals stimulate interleukin‐6 production and secretion by human monocytes and synoviocytes

1989 • 187 citations

The Immunologic Release of Constituents from Neutrophil Leukocytes

1971 • 177 citations

lnterleukin-6 (IL-6) in Synovial Fluid and Serum of Patients with Rheumatic Diseases

1988 • 143 citations

Interleukin‐1‐induced interleukin‐6 is required for the inhibition of proteoglycan synthesis by interleukin‐1 in human articular cartilage

1990 • 129 citations

IL-6 functions as an exocrine hormone in inflammation. Hepatocytes undergoing acute phase responses require exogenous IL-6.

1990 • 127 citations

IL-6/IFN-beta 2 in synovial effusions of patients with rheumatoid arthritis and other arthritides. Identification of several isoforms and studies of cellular sources.

1989 • 113 citations

Interleukin-6 in synovial fluid from patients with arthritis

1989 • 105 citations

In vivo effects of human recombinant interleukin 6 on hemopoietic stem and progenitor cells and circulating blood cells in normal mice.

1990 • 64 citations

Glucocorticosteroid‐dependent synergy between interleukin 1 and interleukin 6 for human B lymphocyte differentiation

1988 • 59 citations

Interleukin-6 and its receptor during homeostasis, inflammation, and tumor growth

1989 • 52 citations

Monocyte-derived human B-cell growth factor identified as interferon-beta 2 (BSF-2, IL-6)

1988 • 51 citations

Correlation of synovial fluid interleukin 6 (IL-6) activities with IgG concentrations in patients with inflammatory joint disease and osteoarthritis.

1989 • 51 citations

Monoclonal antibodies detect monocyte/macrophage activation and differentiation antigens and identify functionally distinct subpopulations of human rheumatoid synovial tissue macrophages.

1991 • 46 citations

Anaemia of chronic disease in rheumatoid arthritis

1990 • 45 citations

IL‐6 Is the Principal Factor Produced by Synovia of Patients with Rheumatoid Arthritis That Induces B‐Lymphocytes to Secrete Immunoglobulins

1989 • 44 citations

Rheumatoid adherent synovial cells produce B cell differentiation factor activity neutralizable by antibody to B cell stimulatory factor-2/interleukin 6.

1988 • 20 citations

[Significance of the concepts basic activity and actual activity in the morphological evaluation of synovial membranes in rheumatoid arthritis].

1974 • 18 citations

Interference of cartilage surface with interaction of granulocyte elastase with ?1-proteinase inhibitor

1987 • 17 citations

Interleukin 6 is essential for antibody secretion by human in vivo antigen-induced lymphoblastoid B cells

1990 • 15 citations

Interleukin 1 induces different cytokines in human fibroblasts.

1989 • 11 citations

Growth and differentiation of B lymphocytes of patients with juvenile rheumatoid arthritis.

1990 • 5 citations